Journal of Ginseng Research

  • 제36권1호
  • /
  • Pages.27-39
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  • 2012
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  • 1226-8453(pISSN)
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  • 2093-4947(eISSN)
고려인삼학회 (The Korean Society of Ginseng)
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Ginseng and Diabetes: The Evidences from In Vitro, Animal and Human Studies

  • Yuan, Hai-Dan (Department of Pharmacology and Clinical Pharmacy, College of Pharmacy, Kyung Hee University) ;
  • Kim, Jung-Tae (Department of Pharmacology and Clinical Pharmacy, College of Pharmacy, Kyung Hee University) ;
  • Kim, Sung-Hoon (Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyung Hee University) ;
  • Chung, Sung-Hyun (Department of Pharmacology and Clinical Pharmacy, College of Pharmacy, Kyung Hee University)
  • 투고 : 2011.10.13
  • 심사 : 2011.12.02
  • 발행 : 2012.01.11
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초록

Panax ginseng exhibits pleiotropic beneficial effects on cardiovascular system, central nervous system, and immune system. In the last decade, numerous preclinical findings suggest ginseng as a promising therapeutic agent for diabetes prevention and treatment. The mechanism of ginseng and its active components is complex and is demonstrated to either modulate insulin production/secretion, glucose metabolism and uptake, or inflammatory pathway in both insulin-dependent and insulin-independent manners. However, human studies are remained obscure because of contradictory results. While more studies are warranted to further understand these contradictions, ginseng holds promise as a therapeutic agent for diabetes prevention and treatment. This review summarizes the evidences for the therapeutic potential of ginseng and ginsenosides from in vitro studies, animal studies and human clinical trials with a focus on diverse molecular targets including an AMP-activated protein kinase signaling pathway.

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참고문헌

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피인용 문헌

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  2. Tang-Nai-Kang Alleviates Pre-diabetes and Metabolic Disorders and Induces a Gene Expression Switch toward Fatty Acid Oxidation in SHR.Cg-Leprcp/NDmcr Rats vol.10, pp.4, 2015, https://doi.org/10.1371/journal.pone.0122024
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  14. Protopanaxadiol and Protopanaxatriol-Type Saponins Ameliorate Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus in High-Fat Diet/Streptozocin-Induced Mice vol.8, pp.1663-9812, 2017, https://doi.org/10.3389/fphar.2017.00506
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  33. Effects of Ginsenoside Rg1 Regulating Wnt/ β -Catenin Signaling on Neural Stem Cells to Delay Brain Senescence vol.2019, pp.None, 2019, https://doi.org/10.1155/2019/5010184
  34. Enhanced Intestinal Permeability and Plasma Concentration of Metformin in Rats by the Repeated Administration of Red Ginseng Extract vol.11, pp.4, 2012, https://doi.org/10.3390/pharmaceutics11040189
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  38. Antihypertensive Effects of Rg3-Enriched Korean Vitamin Ginseng in Spontaneously Hypertensive Rats vol.15, pp.1, 2012, https://doi.org/10.1177/1934578x19900712
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  40. Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases vol.2020, pp.None, 2020, https://doi.org/10.1155/2020/6565396
  41. Herb–Drug Interaction of Red Ginseng Extract and Ginsenoside Rc with Valsartan in Rats vol.25, pp.3, 2020, https://doi.org/10.3390/molecules25030622
  42. 고려인삼과 당뇨병: 세포와 동물 및 인체실험을 통한 고려인삼의 당뇨병에 대한 효능 vol.51, pp.1, 2012, https://doi.org/10.22889/kjp.2020.51.1.001
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  50. Effect of Panax notoginseng Saponins and Major Anti-Obesity Components on Weight Loss vol.11, pp.None, 2021, https://doi.org/10.3389/fphar.2020.601751
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  52. Phnomibacter ginsenosidimutans gen. nov., sp. nov., a novel glycoside hydrolase positive bacterial strain with ginsenoside hydrolysing activity vol.71, pp.5, 2021, https://doi.org/10.1099/ijsem.0.004793
  53. Effect of Lactic Acid Bacteria on the Pharmacokinetics and Metabolism of Ginsenosides in Mice vol.13, pp.9, 2012, https://doi.org/10.3390/pharmaceutics13091496
  54. The complete mitochondrial genome of Panax ginseng (Apiales, Araliaceae): an important medicinal plant vol.6, pp.10, 2021, https://doi.org/10.1080/23802359.2021.1981167
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