The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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A Case of Severe Gingival Overgrowth Caused by Long-Term Amlodipine Treatment

장기간 Amlodipine 복용 후 발생한 심한 잇몸 과증식 1예

  • Lee, Sung-Jin (Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea College of Medicine) ;
  • Chung, Young-Kuk (Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea College of Medicine) ;
  • Lee, Hae-Lim (Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea College of Medicine) ;
  • Choi, Su-Jin (Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea College of Medicine) ;
  • Cho, Sung-Yeon (Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea College of Medicine) ;
  • Choi, Hyun-Joo (Department of Hospital Pathology, St. Vincent's Hospital, The Catholic University of Korea College of Medicine) ;
  • Kim, Hyung-Wook (Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea College of Medicine)
  • 이성진 (가톨릭대학교 의과대학 성빈센트병원 내과학교실) ;
  • 정영국 (가톨릭대학교 의과대학 성빈센트병원 내과학교실) ;
  • 이해림 (가톨릭대학교 의과대학 성빈센트병원 내과학교실) ;
  • 최수진 (가톨릭대학교 의과대학 성빈센트병원 내과학교실) ;
  • 조성연 (가톨릭대학교 의과대학 성빈센트병원 내과학교실) ;
  • 최현주 (가톨릭대학교 의과대학 성빈센트병원 병원병리학교실) ;
  • 김형욱 (가톨릭대학교 의과대학 성빈센트병원 내과학교실)
  • Published : 2012.05.01
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Abstract

Amlodipine is one of the most commonly used calcium-channel blockers for the management of hypertension in Korea. Gingival overgrowth is an infrequent complication in patients receiving amlodipine treatment. A 52-year-old man on an amlodipine regimen of 10 mg/day for 25 months sought medical attention because of gradually progressive gingival enlargement. Examination of the oral cavity revealed severe gingival overgrowth. We stopped the amlodipine treatment and recommended the maintenance of good oral hygiene and a gingivectomy. Histological findings of the gingivectomy were typical of drug-induced gingival overgrowth, including epithelial thickening with proliferation, acanthosis with elongated rete ridges, and focal parakeratosis. A marked reduction in gingival overgrowth was evident 1 month after the gingivectomy and cessation of amlodipine. This report describes the case of a 52-year-old man who developed severe and histologically confirmed amlodipine-induced gingival overgrowth.

약제의 의한 잇몸 과증식은 주로 phenytoin (dilantin), cyclosporine, 칼슘통로 차단제에 의해 발생한다. 칼슘통로 차단제 중에서는 nifedipine에 의한 경우가 가장 많으나 amlodpine을 포함한 다른 종류의 칼슘 통로 차단제에 의해서도 드물게 발생할 수 있다고 알려져 있다. Amlodipine은 국내에서 혈압 조절을 위해 많이 처방되는 약제로서 이 약을 복용 중인 환자에서 잇몸 과증식의 발생에 대한 관찰과 주의가 필요하다. 본 저자들은 amlodipine에 의한 잇몸 과증식을 약물중단과 수술로 치료하고 조직 소견을 확인한 1예를 경험하였기에 이를 문헌고찰과 함께 보고하는 바이다.

Keywords

References

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