The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Effects of Add-On Therapy with NDC-052, an Extract from Magnoliae Flos, in Adult Asthmatic Patients Receiving Inhaled Corticosteroids

  • Park, Chan-Sun (Department of Internal Medicine, Heaundae Paik Hospital, Inje University) ;
  • Kim, Tae-Bum (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Jae-Young (Department of Pulmonary, Allergy and Critical Care Medicine, Hallym University College of Medicine) ;
  • Park, Jae-Yong (Department of Internal Medicine, Kyungpook National University Hospital) ;
  • Lee, Yong-Chul (Department of Internal Medicine, Research Center for Pulmonary Disorders, Research Institute of Clinical Medicine, Chonbuk National University Medical School) ;
  • Jeong, Seong-Su (Department of Internal Medicine, Chungnam National University Hospital) ;
  • Lee, Yang-Deok (Department of Internal Medicine, Eulji University School of Medicine) ;
  • Cho, You-Sook (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Moon, Hee-Bom (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine)
  • Published : 2012.03.01
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Abstract

Background/Aims: There is a need for new anti-asthmatic medications with fewer side effects. NDC-052, an extract of the medicinal herb Magnoliae flos, which has a long history of clinical use, was recently found to have anti-inflammatory effects. Herein, we evaluated the effects of NDC-052 as an add-on therapy in patients with mild to moderate asthma using inhaled corticosteroids (ICS). Methods: In a non-comparative, multi-center trial, 148 patients taking ICS received NDC-052 for eight weeks. We evaluated their forced expiratory volume in one second (FEV1), morning and evening peak expiratory flow rate (AM and PM PEFR), AM/PM asthma symptom scores, visual analogue symptom (VAS) scores, night-time wakening, frequency of short-acting ${\beta}2-agonist$ usage, and adverse events. Results: After eight weeks, both AM and PM PEFRs were significantly improved. Asthma symptom scores, VAS scores, the frequency of nights without awakening, and the frequency of ${\beta}2-agonist$ use were also reduced. Most of the adverse drug reactions were mild and resolved spontaneously. Conclusions: The addition of NDC-052 to ICS had a beneficial effect on asthma control in patients with mild to moderate asthma, with good tolerability and fewer side effects. Further studies are necessary to evaluate the effects of NDC-052 in patients with severe and/or refractory asthma.

Keywords

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