Clinical Endoscopy

  • 제45권2호
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  • Pages.138-144
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  • 2012
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  • 2234-2400(pISSN)
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  • 2234-2443(eISSN)
대한소화기내시경학회 (The Korean Society of Gastrointestinal Endoscopy)
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Non-Steroidal Anti-Inflammatory Drug-Induced Enteropathy

  • Lim, Yun-Jeong (Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University Graduate School of Medicine) ;
  • Yang, Chang-Hun (Department of Internal Medicine, Dongguk University Gyeongju Hospital, Dongguk University School of Medicine)
  • 투고 : 2012.02.09
  • 심사 : 2012.04.19
  • 발행 : 2012.06.30
⟨ 이전 논문 다음 논문 ⟩

초록

Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed drugs in the world. NSAID-induced lower gastrointestinal (GI) complications are increasing while upper GI complications are decreasing. Lower GI events accounted for 40% of all serious GI events in patients on NSAIDs. Capsule endoscopy and device assisted enteroscopy are available for detection of small intestinal lesions. Capsule endoscopy studies have demonstrated that NSAIDs use in healthy volunteers raised the incidence (55% to 75%) of intestinal damage. It appears that selective cyclooxygenase-2 inhibitors (coxibs) improved upper and lower GI safety based on results of clinical trials. Selective coxibs are still capable of triggering GI adverse events and cardiovascular toxicity issues were the main focus of concerns. Unfortunately, definite strategies are not available to prevent or heal NSAID-induced intestinal injuries. Thus, there is still a strong clinical need for effective drugs with improved safety profiles than the existing NSAIDs.

키워드

피인용 문헌

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