Clinical Endoscopy

  • 제45권2호
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  • Pages.161-164
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  • 2012
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  • 2234-2400(pISSN)
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  • 2234-2443(eISSN)
대한소화기내시경학회 (The Korean Society of Gastrointestinal Endoscopy)
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Effectiveness of Premedication with Pronase for Visualization of the Mucosa during Endoscopy: A Randomized, Controlled Trial

  • Lee, Gyu-Jin (Department of Gastroenteology, Kosin University College of Medicine) ;
  • Park, Seun-Ja (Department of Gastroenteology, Kosin University College of Medicine) ;
  • Kim, Sun-Jung (Department of Gastroenteology, Kosin University College of Medicine) ;
  • Kim, Hyung-Hun (Department of Gastroenteology, Kosin University College of Medicine) ;
  • Park, Moo-In (Department of Gastroenteology, Kosin University College of Medicine) ;
  • Moon, Won (Department of Gastroenteology, Kosin University College of Medicine)
  • 투고 : 2011.07.26
  • 심사 : 2011.12.29
  • 발행 : 2012.06.30
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: Gastric mucus should be removed before endoscopic examination to increase visibility. In this study, the effectiveness of premedication with pronase for improving visibility during endoscopy was investigated. Methods: From April 2010 to February 2011, 400 outpatients were randomly assigned to receive endoscopy with one of four premedications as follows: dimethylpolysiloxane (DMPS), pronase and sodium bicarbonate with 10 minutes premedication time (group A, n=100), DMPS and sodium bicarbonate with 10 minutes premedication time (group B, n=100), DMPS, pronase and sodium bicarbonate with 20 minutes premedication time (group C, n=100), and DMPS and sodium bicarbonate with 20 minute premedication time (group D, n=100). One endoscopist, who was unaware of the premedication types, calculated the visibility scores (range, 1 to 3) of the antrum, lower gastric body, upper gastric body and fundus. The sum of the scores from the four locations was defined as the total visibility score. Results: Group C showed significantly lower scores than other groups (p=0.002). Group C also had the lowest frequency of flushing, which was significantly lower than that of group D. Groups C and D had significantly shorter durations of examination than groups A and B. Conclusions: Using pronase 20 minutes before endoscopy significantly improved endoscopic visualization and decreased the frequency of water flushing.

키워드

피인용 문헌

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