Korean Journal of Radiology

  • 제13권2호
  • /
  • Pages.152-164
  • /
  • 2012
  • /
  • 1229-6929(pISSN)
  • /
  • 2005-8330(eISSN)
대한영상의학회 (The Korean Society of Radiology)
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DOI QR코드

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80-kVp CT Using Iterative Reconstruction in Image Space Algorithm for the Detection of Hypervascular Hepatocellular Carcinoma: Phantom and Initial Clinical Experience

  • Hur, Sae-Beom (Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Lee, Jeong-Min (Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Kim, Soo-Jin (Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Park, Ji-Hoon (Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Han, Joon-Koo (Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Choi, Byung-Ihn (Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine)
  • 발행 : 2012.04.01
⟨ 이전 논문 다음 논문 ⟩

초록

Objective: To investigate whether the low-tube-voltage (80-kVp), intermediate-tube-current (340-mAs) MDCT using the Iterative Reconstruction in Image Space (IRIS) algorithm improves lesion-to-liver contrast at reduced radiation dosage while maintaining acceptable image noise in the detection of hepatocellular carcinomas (HCC) in thin (mean body mass index, $24{\pm}0.4kg/m^{2}$) adults. Subjects and Methods: A phantom simulating the liver with HCC was scanned at 50-400 mAs for 80, 100, 120 and 140-kVp. In addition, fifty patients with HCC who underwent multiphasic liver CT using dual-energy (80-kVp and 140-kVp) arterial scans were enrolled. Virtual 120-kVP scans (protocol A) and 80-kVp scans (protocol B) of the late arterial phase were reconstructed with filtered back-projection (FBP), while corresponding 80-kVp scans were reconstructed with IRIS (protocol C). Contrast-to-noise ratio (CNR) of HCCs and abdominal organs were assessed quantitatively, whereas lesion conspicuity, image noise, and overall image quality were assessed qualitatively. Results: IRIS effectively reduced image noise, and yielded 29% higher CNR than the FBP at equivalent tube voltage and current in the phantom study. In the quantitative patient study, protocol C helped improve CNR by 51% and 172% than protocols A and B (p < 0.001), respectively, at equivalent radiation dosage. In the qualitative study, protocol C acquired the highest score for lesion conspicuity albeit with an inferior score to protocol A for overall image quality (p < 0.001). Mean effective dose was 2.63-mSv with protocol A and 1.12-mSv with protocols B and C. Conclusion: CT using the low-tube-voltage, intermediate-tube-current and IRIS help improve lesion-to-liver CNR of HCC in thin adults during the arterial phase at a lower radiation dose when compared with the standard technique using 120-kVp and FBP.

키워드

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