한국수산과학회지 (Korean Journal of Fisheries and Aquatic Sciences)

  • 제45권6호
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  • Pages.675-678
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  • 2012
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  • 0374-8111(pISSN)
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  • 2287-8815(eISSN)
한국수산과학회 (The Korean Society of Fisheries and Aquatic Science)
권호 표지
DOI QR코드

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레바미졸이 틸라피아(Oreochromis niloticus)의 자연살해세포 활성에 미치는 영향

Effect of Levamisole on Enhancing Natural Cytotoxic Cell Activity in Nile Tilapia Oreochromis niloticus

  • 박관하 (군산대학교 수산생명의학과) ;
  • 윤종만 (군산대학교 수산생명의학과) ;
  • 최상훈 (군산대학교 수산생명의학과)
  • Park, Kwan-Ha (Department of Aquatic Life Medicine, Kunsan National University) ;
  • Yoon, Jong-Man (Department of Aquatic Life Medicine, Kunsan National University) ;
  • Choi, Sanghoon (Department of Aquatic Life Medicine, Kunsan National University)
  • 투고 : 2012.09.13
  • 심사 : 2012.12.20
  • 발행 : 2012.12.31
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초록

The study examined the effect of levamisole on the natural cytotoxic cell (NCC) activity of Nile tilapia (Oreochromis niloticus) head kidney (HK) leukocytes. In vitro, HK leukocytes were incubated with $10^{-4}$ to $10^4$ ng of levamisole/ml for 5, 20 or 40 h and then their NCC activity against target cells was assayed. The NCC activity appeared to increase after a 20 h of incubation. In vivo, tilapia were fed commercial diet containing 0, 50, 100 or 300 mg of levamisole/kg for 12 consecutive days. Then, the fish were fed a commercial normal diet and samples harvested weekly 0 to 8 weeks after levamisole administration. The NCC activity was augmented uniformly at all times examined until the end of the experiment. In conclusion, levamisole effectively enhanced and maintained tilapia NCC activity.

키워드

참고문헌

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