Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Early neurodevelopment in very low birth weight infants with mild intraventricular hemorrhage or those without intraventricular hemorrhage

  • Choi, Il Rak (Department of Pediatrics, Ajou University School of Medicine) ;
  • Lee, Jang Hoon (Department of Pediatrics, Ajou University School of Medicine) ;
  • Park, Moon Sung (Department of Pediatrics, Ajou University School of Medicine) ;
  • Kim, Ji Yeon (Department of Pediatrics, Korea University College of Medicine) ;
  • Park, Kyu Hee (Department of Pediatrics, Korea University College of Medicine) ;
  • Kim, Gun-Ha (Department of Pediatrics, Korea University College of Medicine) ;
  • Eun, So-Hee (Department of Pediatrics, Korea University College of Medicine)
  • Received : 2012.07.23
  • Accepted : 2012.10.09
  • Published : 2012.11.15
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Abstract

Purpose: This study aimed to assess early development in very low birth weight (VLBW) infants with mild intraventricular hemorrhage (IVH) or those without IVH and to identify the perinatal morbidities affecting early neurodevelopmental outcome. Methods: Bayley Scales of Infant Development-II was used for assessing neurological development in 49 infants with a birth weight <1,500 g and with low grade IVH (${\leq}$grade II) or those without IVH at a corrected age of 12 months. Results: Among the 49 infants, 19 infants (38.8%) showed normal development and 14 (28.6%) showed abnormal mental and psychomotor development. Infants with abnormal mental development (n=14) were mostly male and had a longer hospitalization, a higher prevalence of patent ductus arteriosus (PDA) and bronchopulmonary dysplasia (BPD), and were under more frequent postnatal systemic steroid treatment compared with infants with normal mental development (n=35, P<0.05). Infants with abnormal psychomotor development (n=29) had a longer hospitalization and more associated PDA compared to infants with normal psychomotor development (n=20, P<0.05). Infants with abnormal mental and psychomotor development were mostly male and had a longer hospitalization and a higher prevalence of PDA and BPD compared to infants with normal mental and psychomotor development (n=19, P<0.05). Using multiple logistic regression analysis, a longer duration of hospitalization and male gender were found to be significant risk factors. Conclusion: Approximately 62% of VLBW infants with low grade IVH or those without IVH had impaired early development.

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References

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  2. No Neurodevelopmental Delay in Preemies With Grade I–II IVH vol.44, pp.5, 2020, https://doi.org/10.1542/gr.44-5-57