DOI QR코드

DOI QR Code

Insertion/deletion (I/D) in the Angiotensin-converting Enzyme Gene and Breast Cancer Risk: Lack of Association in a Meta-analysis

  • Pei, Xin-Hong (Department of Breast Surgery, the First Affiliated Hospital of Zhengzhou University) ;
  • Li, Hui-Xiang (Department of Pathology, the First Affiliated Hospital of Zhengzhou University)
  • Published : 2012.11.30

Abstract

Purpose: Breast cancer is an important cause of cancer-related death in women. Numerous studies have evaluated the association between the insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene and breast cancer risk. However, the specific association is still controversial rather than conclusive. Therefore, we performed a meta-analysis of related studies to address this controversy. Methods: PubMed, EMBASE, Google Scholar and the Chinese National Knowledge Infrastructure databases were systematically searched to identify relevant studies. A meta-analysis was performed to examine the association between the I/D polymorphism in the ACE gene and susceptibility to breast cancer. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. Results: 10 separate studies of 7 included articles with 10,888 subjects on the relation between the I/D polymorphism in the ACE gene and breast cancer were analyzed by meta-analysis, and our results showed no association between the I/D polymorphism in the ACE gene and breast cancer in total population and different populations. No publication bias was found in the present study. Conclusions: The ACE I/D polymorphism may not be associated with breast cancer risk. Further large and well-designed studies are needed to confirm this conclusion.

Keywords

References

  1. Ager EI, Neo J, Christophi C (2008). The renin-angiotensin system and malignancy. Carcinogenesis, 29, 1675-84. https://doi.org/10.1093/carcin/bgn171
  2. Alves Corre.a SA, Ribeiro de Noronha SM, Nogueira-de-Souza NC, et al (2009). Association between the angiotensinconverting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women. J Renin Angiotensin Aldosterone Syst, 10, 51-8. https://doi.org/10.1177/1470320309102317
  3. Attia J, Thakkinstian A, D'Este C (2003). Meta-analyses of molecular association studies: methodologic lessons for genetic epidemiology. J Clin Epidemiol, 56, 297-303. https://doi.org/10.1016/S0895-4356(03)00011-8
  4. Gonzalez-Zuloeta LAM, Arias VA, Sayed-Tabatabaei FA, et al (2005). Angiotensin-converting enzyme gene insertion/ deletion polymorphism and breast cancer risk. Cancer Epidemiol Biomarkers Prev, 14, 2143-6. https://doi.org/10.1158/1055-9965.EPI-05-0045
  5. Haiman CA, Henderson SO, Bretsky P, et al (2003). Genetic variation in angiotensin I-converting enzyme (ACE) and breast cancer risk: the multiethnic cohort. Cancer Res, 63, 6984-7.
  6. Koh WP, Yuan JM, Sun CL, et al (2003). Angiotensin I-converting enzyme (ACE) gene polymorphism and breast cancer risk among Chinese women in Singapore. Cancer Res, 63, 5738.
  7. Lever AF, Hole DJ, Gillis CR, et al (1998). Do inhibitors of angiotensin-I-converting enzyme protect against risk of cancer? Lancet, 352, 179-84. https://doi.org/10.1016/S0140-6736(98)03228-0
  8. Mendizabal-Ruiz AP, Morales JA, Castro Marti Nez X, et al (2011). RAS polymorphisms in cancerous and benign breast tissue. J Renin Angiotensin Aldosterone Syst, 12, 85-92. https://doi.org/10.1177/1470320310383735
  9. Namazi S, Monabati A, Ardeshir-Rouhani-Fard S (2010). Association of angiotensin I converting enzyme (insertion/ deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms with breast cancer prognostic factors in Iranian population. Mol Carcinog, 49, 1022-30. https://doi.org/10.1002/mc.20685
  10. Rigat B, Hubert C, Alhenc-Gelas F, et al (1990). An insertion/ deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest, 86, 1343-6. https://doi.org/10.1172/JCI114844
  11. Rocken C, Lendeckel U, Dierkes J, et al (2005).The number of lymph node metastases in gastric cancer correlates with the angiotensin I-converting enzyme gene insertion/deletion polymorphism.Clin Cancer Res, 11, 2526-30. https://doi.org/10.1158/1078-0432.CCR-04-1922
  12. Wacholder S, Hartge P, Prentice R, et al(2010). Performance of common genetic variants in breast-cancer risk models. N Engl J Med, 362, 986-993. https://doi.org/10.1056/NEJMoa0907727
  13. Sayed-Tabatabaei FA, Schut AF, Hofman A,et al(2004).A study of gene-environment interaction on the gene for angiotensin converting enzyme: a combined functional and population based approach. J Med Genet, 41, 99-103. https://doi.org/10.1136/jmg.2003.013441
  14. Setiawan VW, Monroe KR, Wilkens LR, et al(2009). Breast cancer risk factors defined by estrogen and progesterone receptor status: the multiethnic cohort study. Am J Epidemiol, 169, 1251-9. https://doi.org/10.1093/aje/kwp036
  15. Smigal C, Jemal A, Ward E, et al (2006). Trends in breast cancer by race and ethnicity: update 2006. CA Cancer J Clin, 56, 168-83. https://doi.org/10.3322/canjclin.56.3.168
  16. Van der Knaap R, Siemes C, Coebergh JW, et al (2008). Renin- angiotensin system inhibitors, angiotensin I-converting enzyme gene insertion/deletion polymorphism, and cancer: the Rotterdam Study. Cancer, 112, 748-57. https://doi.org/10.1002/cncr.23215
  17. Villard E, Tiret L, Visvikis S, et al (1996). Identification of new polymorphisms of the angiotensin I-converting enzyme (ACE) gene, and study of their relationship to plasma ACE levels by two-QTL segregation-linkage analysis. Am J Hum Genet, 58, 1268-78.
  18. Wang YJ, Pan Y (2012). Angiotensinogen gene M235T polymorphism and risk of coronary artery disease: A metaanalysis. Mol Med Report, 6, 884-8. https://doi.org/10.3892/mmr.2012.1011
  19. Yaren A, Turgut S, Kursunluoglu R, et al (2007). Insertion/ deletion polymorphism of the angiotensin I-converting enzyme gene in patients with breast cancer and effects on prognostic factors. J Investig Med, 55, 255-61. https://doi.org/10.2310/6650.2007.00006
  20. Yuan JM, Koh WP, Sun CL, et al (2005). Green tea intake, ACE gene polymorphism and breast cancer risk among Chinese women in Singapore. Carcinogenesis, 26,1389-94. https://doi.org/10.1093/carcin/bgi080

Cited by

  1. Association of ACE I/D polymorphism with obstructive sleep apnea susceptibility: evidence based on 2,228 subjects vol.18, pp.3, 2014, https://doi.org/10.1007/s11325-013-0912-6
  2. Interaction of Tobacco Smoking and Chewing with Angiotensin Converting Enzyme (Insertion/Deletion) Gene Polymorphisms and Risk of Lung Cancer in a High Risk Area from Northeast India vol.15, pp.24, 2014, https://doi.org/10.7314/APJCP.2014.15.24.10691
  3. Lack of association of angiotensin-converting enzyme insertion/deletion polymorphism with breast cancer: An update meta-analysis based on 10405 subjects vol.16, pp.4, 2015, https://doi.org/10.1177/1470320314529357
  4. Synergistic association of six well-characterized polymorphisms in three genes of the renin-angiotensin system with breast cancer among Han Chinese women vol.16, pp.4, 2015, https://doi.org/10.1177/1470320314542828