Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Improvement of High-fat Diet-induced Obesity by Xanthigen in C57BL/6N Mice

잔티젠(Xanthigen)에 의한 고지방식이로 유도된 비만 개선 효과

  • Choi, Kyeong-Mi (College of Pharmacy, Chungbuk National University) ;
  • Lee, Youn-Sun (College of Pharmacy, Chungbuk National University) ;
  • Kim, Wonkyun (College of Pharmacy, Chungbuk National University) ;
  • Choi, Yung-Hyun (Department of Biochemistry, College of Oriental Medicine, Department of Biomaterial Control, Anti-Aging Research Center and Blue-Bio Industry RIC, Dong-Eui University) ;
  • Kwak, Youn-Gil (Rexgene Biotech Co., Ltd.) ;
  • Jung, Jae-Chul (Rexgene Biotech Co., Ltd.) ;
  • Lee, Jeongrai (Rexgene Biotech Co., Ltd.) ;
  • Yoo, Hwan-Soo (College of Pharmacy, Chungbuk National University)
  • 최경미 (충북대학교 약학대학) ;
  • 이윤선 (충북대학교 약학대학) ;
  • 김원균 (충북대학교 약학대학) ;
  • 최영현 (동의대학교 한의과대학 생화학교실, 블루바이오 소재개발 및 실용화 지원센터) ;
  • 곽연길 (렉스진 바이오텍) ;
  • 정재철 (렉스진 바이오텍) ;
  • 이정래 (렉스진 바이오텍) ;
  • 유환수 (충북대학교 약학대학)
  • Received : 2012.11.15
  • Accepted : 2012.11.26
  • Published : 2012.12.30
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Abstract

Obesity is a risk factor for numerous metabolic diseases. Recently, naturally occurring compounds that may improve obesity have received increasing attention. Xanthigen is a mixture of fucoxanthin and punicic acid derived from brown seaweed and pomegranate seed, respectively, which have been traditionally used for lipid-lowering effects in humans. In this study, we investigated whether Xanthigen attenuates high-fat diet-induced obesity in C57BL/6N mice. The mice were fed on a normal diet (ND), high-fat diet (HFD), HFD plus 1% Xanthigen or HFD plus 1% green tea extract (GTE) for 11 weeks. Food efficiency ratio (FER) and body weight were significantly reduced in mice fed HFD plus Xanthigen compared to HFD-fed mice. Consistent with the results in body weight change, Xanthigen also significantly decreased the weights of epididymal adipose tissue, retroperitoneal adipose tissue, and liver in HFD plus 1% Xanthigen-fed mice. The serum level of low-density lipoprotein (LDL)-cholesterol was significantly decreased in HFD plus Xanthigen-fed mice compared to HFD-fed mice. These results suggest that Xanthigen may be useful in the development of a functional health food for anti-obesity.

비만은 대사성 질환의 주요 위험 인자이다. 최근, 천연물질들의 비만 개선효과에 관심이 집중되고 있다. 잔티젠은 체중감소와 지질 대사 개선 효과가 있는 것으로 알려진 미역에서 유래한 fucoxanthin과 석류씨 오일에서 유래한 punicic acid로 구성된 복합 추출물이다. 본 연구에서, 우리는 C57BL/6N 마우스를 이용하여 잔티젠이 고지방식이로 유도된 비만을 개선시킬 수 있는지 조사하였다. 마우스는 각각 정상식이 대조군, 고지방식이 대조군, 고지방식이 + 1% 잔티젠군, 고지방식이 + 1% 녹차 추출물 양성대조군으로 나누어 11주간 사육하였다. 잔티젠 투여군은 고지방식이군과 비교하여 식이효율과 체중이 유의적으로 감소하였다. 체중 변화와 유사하게, 잔티젠은 복부부고환 지방조직과 후복막 지방조직 및 간의 무게를 고지방식이군 대비 뚜렷하게 감소시켰고, 혈청 LDL-콜레스테롤 함량 또한 유의적으로 감소시켰다. 이러한 결과들은 잔티젠의 탁월한 항비만 효과를 갖는 건강기능식품 소재로서의 개발 가능성을 제시한다.

Keywords

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