한국동물위생학회지 (Korean Journal of Veterinary Service)

  • 제35권4호
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  • Pages.307-312
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  • 2012
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  • 3022-7372(pISSN)
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  • 2287-7630(eISSN)
한국동물위생학회 (The Korean Society of Veterinary Service)
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자돈에서 Sus scrofa ferritin Heavy-chain 생산 재조합 효모의 효과

Effect of recombinant yeast producing Sus scrofa ferritin Heavy-chain on piglets

  • 최영준 (강원대학교 수의학대학) ;
  • 임환 (강원대학교 수의학대학) ;
  • 김현철 (강원대학교 수의학대학) ;
  • 김종택 (강원대학교 수의학대학) ;
  • 이기종 (연세대학교 보건과학대학 임상병리학과) ;
  • 정배동 (강원대학교 수의학대학)
  • Choi, Young-Jun (College of Veterinary Medicine, Kangwon National University) ;
  • Lim, Hwan (College of Veterinary Medicine, Kangwon National University) ;
  • Kim, Hyeon-Cheol (College of Veterinary Medicine, Kangwon National University) ;
  • Kim, Jong-Taek (College of Veterinary Medicine, Kangwon National University) ;
  • Rhee, Ki-Jong (Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University at Wonju) ;
  • Jung, Bae-Dong (College of Veterinary Medicine, Kangwon National University)
  • 투고 : 2012.07.24
  • 심사 : 2012.08.03
  • 발행 : 2012.12.30
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초록

Iron deficiency anemia is also recognized as a serious disorder in many livestock, especially, piglets. We previously studied that the iron-fortified yeast (Saccharomyces cerevisiae) producing Sus scrofa ferritin heavy-chain (FER) was bioavailable to mice with iron deficiency. In this study, we determined whether FER could improve iron deficiency in piglets. The bioavailability of FER was examined by measuring body weight gain, hemoglobin concentration and hematocrit value in suckling and weaning piglets. We found that FER significantly increased hemoglobin value and the hematocrit ratio in suckling piglets (P<0.05). Furthermore, FER treatment significantly enhanced body weight gain in both groups of the suckling and weaning piglets (P<0.05). These results suggest that the iron-fortified recombinant yeast strain is helpful in iron absorption in piglets.

키워드

참고문헌

  1. Baynes RD, Bothwell TH. 1990. Iron deficiency. Annu Rev Nutr 10: 133-148. https://doi.org/10.1146/annurev.nu.10.070190.001025
  2. Bermejo F, Garcia-Lopez S. 2009. A guide to diagnosis of iron deficiency and iron deficiency anemia in digestive diseases. World J Gastroenterol 15: 4638-4643. https://doi.org/10.3748/wjg.15.4638
  3. Chang YJ, Jo MY, Hwang EH, Park CU, Kim KS. 2005. Recovery from iron deficiency in rats by the intake of recombinant yeast producing human H-ferritin. Nutrition 21: 520-524. https://doi.org/10.1016/j.nut.2004.07.016
  4. Clark SF. 2009. Iron deficiency anemia: diagnosis and management. Curr Opin Gastroenterol 25: 122-128 https://doi.org/10.1097/MOG.0b013e32831ef1cd
  5. Drysdale, JW, Adelman TG, Arosio P, Casareale D, Fitzpatrick P, Harzard JT, Yokota M. 1977. Human isoferritins in normal and disease states. Semin Hematol 14: 71-88.
  6. Egeli AK, Framstad T. 1999. An evaluation of iron-dextran supplementation in piglets administered by injection on the first, third or fourth day after birth. Res Vet Sci 66: 179-184. https://doi.org/10.1053/rvsc.1998.0223
  7. Furugouri K, Miyata Y, Shijimaya K, Narasaki N. 1983. Developmental changes in serum ferritin of piglets. J Anim Sci 57: 960-965. https://doi.org/10.2527/jas1983.574960x
  8. Gasche C, Lomer MC, Cavill I, Weiss G. 2004. Iron, anaemia, and inflammatory bowel diseases. Gut 53: 1190-1197. https://doi.org/10.1136/gut.2003.035758
  9. Harrison PM, Arosio P. 1996. The ferritins: molecular properities iron storage function and cellular regulation. Biochim Biophys Acta 1275: 161-203. https://doi.org/10.1016/0005-2728(96)00022-9
  10. Leung AK, Chan KW. 2001. Iron deficiency anemia. Adv Pediatr 48: 385-408.
  11. Lim H, Kim JT, Kim MD, Rhee KJ, Jung BD. 2012. Iron-fortified recombinant Saccharomyces cerevisiae producing Sus scrofa ferritin heavy-chain recovers iron deficiency in mice. Korean J Vet Res 52: 263-268.
  12. Lipinski P, Starzynki RR, Canonne-Hergaux F, Tudek B, Olinski R, Kowalczyk P, Dziaman T, Thibaudeau O, Gralak MA, Smuda E, Wolinski J, Usinska A, Zabielski R. 2010. Benefits and risks of iron supplementation in anemic neonatal pigs. Am J Pathol 177: 1233-1243. https://doi.org/10.2353/ajpath.2010.091020
  13. Mahoney AW, Hendricks DG. 1984. Potential of the rat as a model for predicting iron bioavailability in humans. Nutr Rec 4: 913-922. https://doi.org/10.1016/S0271-5317(84)80067-6
  14. May ME, Fish WW. 1977. The isolation and properties of porcine ferritin and apoferritin. Arch Biochem Biophys 182: 396-403. https://doi.org/10.1016/0003-9861(77)90520-3
  15. Murray-Kolb LE, Takaiwa F, Goto F, Yoshihara T, Theil EC, Beard JL. 2002. Transgenic rice is a source of iron for iron-depleted rats. J Nutr 132: 957-960. https://doi.org/10.1093/jn/132.5.957
  16. Rockey DC. 2005. Occult gastrointestinal bleeding. Gastroenterol Clin North Am 34: 699-718. https://doi.org/10.1016/j.gtc.2005.08.010
  17. Seo HY, Chung YJ, Kim SJ, Park CU, Kim KS. 2003. Enhanced expression and functional characterzation of the human ferritin H- and L-chain genes in Saccharomyces cerevisiae. Appl Microbiol Biotechnol 63: 57-63. https://doi.org/10.1007/s00253-003-1350-3
  18. Strube YN, Beard JL, Ross AC. 2002. Iron deficiency and marginal vitamin A deficiency affect growth, hematological indices and the regulation of iron metabolism genes in rats. J Nutr 132: 3607-3615. https://doi.org/10.1093/jn/132.12.3607
  19. Svoboda M, Drábeck J. 2005. Iron deficiency in suckling piglets: etiology, clinical aspects and diagnosis. Folia Vet 49: 104-111.
  20. Theil EC. 1987. Ferritin: structure, gene regulation, and cellular function in animals, plants, and microorganisms. Annu Rev Biochem 56: 289-315. https://doi.org/10.1146/annurev.bi.56.070187.001445
  21. Venn JA, McCance RA, Widdowson EM. 1947. Iron metabolism in piglet anemia. J Comp Pathol Ther 57: 314-325. https://doi.org/10.1016/S0368-1742(47)80037-2