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Bhopal Methyl Isocyanate Affected Population and Cancer Susceptibility: Where Do We Stand Now?

  • Senthilkumar, Chinnu Sugavanam (Department of Research, Clinical Cytogenetics Laboratory, Jawaharlal Nehru Cancer Hospital and Research Centre (JNCHRC))
  • 발행 : 2012.10.31

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참고문헌

  1. Bucher JR, Uraih L (1989). Carcinogenicity and pulmonary pathology associated with a single 2-hour inhalation exposure of laboratory rodents to methyl isocyanate. J Nat Cancer Inst, 81, 1586-7 https://doi.org/10.1093/jnci/81.20.1586
  2. Dhara VR, Kriebel D (1993). The bhopal gas disaster: It's not too late for sound epidemiology. Arch Environ Hlth, 48, 436-7. https://doi.org/10.1080/00039896.1993.10545966
  3. Ennever FK, Rosenkranz HS (1987). Evaluating the potential for genotoxic carcinogenicity of methyl isocyanate. Toxicol Appl Pharmacol, 91, 502-5. https://doi.org/10.1016/0041-008X(87)90073-1
  4. Gassert T, Mackenzie C, Muir KM, et al (1986). Long term pathology of lung, eye, and other organs following acute exposure of rats to methyl isocyanate. Lancet, 2, 1403.
  5. Hariom P, Mishra PK (2011). Repercussion of isocyanates exposure on different cellular proteins in human pulmonary arterial endothelial cells. Int J Res Chem Env, 1, 95-100.
  6. Hariom P, Raghuram GV, Jain D, et al (2011). Cell cycle deregulation by methyl isocyanate: implications in liver carcinogenesis. Environ Toxicol, 1-14.
  7. ICMR (2004). Health effects of the toxic gas leak from the union carbide Methyl isocyanate plant in Bhopal, Technical Report on Population Based Long Term Clinical Studies (1985 - 1994). Indian Council of Medical Research. New Delhi, India. (Cited August 8, 2012), Available from URL: http://icmr.nic.in/pinstitute/nireh.htm
  8. ICMR (2010). Call for Research Proposals on the long term effect(s) of MIC gas, if any, on the Bhopal Population either exposed or affected (in December 1984). Indian Council of Medical Research, India. (Cited October 1, 2009), Available from URL: http://icmr.nic.in.
  9. Malla TM, Senthilkumar CS, Sharma NC, et al (2011). Chromosome Instability among bhopal gas tragedy survivors. Am Eur J Toxicol Sci, 3, 245-9.
  10. Raghuram GV, Pathak N, Jain D, et al (2010). Molecular mechanisms of isocyanate induced oncogenic transformation in ovarian epithelial cells. Reproduct Toxicol, 30, 377-86. https://doi.org/10.1016/j.reprotox.2010.05.087
  11. Sarangi S, Zaidi T, Pal RK, et al (2010). Effects of exposure of parents to toxic gases in Bhopal on the offspring. Am J Ind Med, 53, 836-41.
  12. Senthilkumar CS, Sah NK, Ganesh N (2012). Methyl Isocyanate and Carcinogenesis: Bridgeable Gaps in Scientific Knowledge. Asian Pac J Cancer Prev, 13, 2429-35 https://doi.org/10.7314/APJCP.2012.13.6.2429
  13. Senthilkumar CS, Tahir M, Sah NK, et al (2011). Cancer morbidity among methyl isocyanate exposed long-term survivors and their offspring: a hospital-based five year descriptive study (2006-2011) and future directions to predict cancer risk in the affected population. Asian Pac J Cancer Prev, 12, 3443-52.
  14. Times of India (2012). Indian council of medical research to take up long-term studies on gas victims. Bhopal. May 17, 2012. (Cited August 8, 2012), Available from URL: http://articles.timesofindia.indiatimes.com/2012-05-17/bhopal/31748733_1_gas-victims-bmhrc-bhopal-gas

피인용 문헌

  1. Increased Micronucleus Frequency in Peripheral Blood Lymphocytes Contributes to Cancer Risk in the Methyl Isocyanate-Affected Population of Bhopal vol.16, pp.10, 2015, https://doi.org/10.7314/APJCP.2015.16.10.4409
  2. In silico docking of methyl isocyanate (MIC) and its hydrolytic product (1, 3-dimethylurea) shows significant interaction with DNA Methyltransferase 1 suggests cancer risk in Bhopal-Gas-Tragedy survivors vol.16, pp.17, 2015, https://doi.org/10.7314/APJCP.2015.16.17.7663
  3. On the long-term effects of methyl isocyanate on cell-mediated immunity in Bhopal gas-exposed long-term survivors and their offspring vol.33, pp.4, 2017, https://doi.org/10.1177/0748233716645480