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The Regulatory Effects of Radiation and Histone Deacetylase Inhibitor on Liver Cancer Cell Cycle

  • Lee, Sang Ho (Department of biology, Dong-eui University) ;
  • Han, Chang Hee (Department of biology, Dong-eui University) ;
  • Kang, Su Man (Department of Radiation Onoldgy, Kosin University Gospd Hospital) ;
  • Park, Cheol Woo (Department of Radiologic Technology, Dong-eui Institute of Technology)
  • Received : 2012.09.21
  • Accepted : 2012.12.05
  • Published : 2012.12.28
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Abstract

Radiation has been an effective tool for treating cancer for a long time. Radiation therapy induces DNA damage within cancer cells and destroys their ability to reproduce. Radiation therapy is often combined with other treatments, like surgery and chemotherapy. Here, we describe the effects of radiation and histone deacetylase inhibitor, Trichostain A, on cell cycle regulation in hepatoma cells. The combinatorial treatment of radiation and Trichostain A induced cell cycle arrest and thereby increasing the hepatoma cell death. Furthermore, the regulatory effects of radiation and Trichostatin A on cell cycle applied in cell type specifically. These results suggest that the treatment of radiation and Trichostatin A may play a central role in hepatoma cell death and might be a good remedy to improve the efficiency of radiation therapy.

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References

  1. K. van Holde, and J. Zlatanova, "What determine the folding of the chromatin fiber?" Proc.Natl.Acad.Sci. U.S.A., vol. 93, no. 30, Oct. 1996, pp. 10548-10555. https://doi.org/10.1073/pnas.93.20.10548
  2. J.L. Workman, and R.E. Kingston, "Alteration of nucleosome structure as a mechanism of transcriptional regulation," Annu.Rev.Biochem., vol. 67, Jul. 1998, pp. 545-579. https://doi.org/10.1146/annurev.biochem.67.1.545
  3. R.D. Kornberg, and Y. Lorch, "Twenty-five years of the nucleosome, fundamental particle of the eukatyote clrromosome," Cell, vol. 98, no. 3, Aug. 1999, pp. 285-294. https://doi.org/10.1016/S0092-8674(00)81958-3
  4. J.M. Espinosa, and B.M. Emerson, "Transcriptional regnlation by p53 through intrinsic DNA/chromatin binding and site-directe d cofactor recruitment," Mol.Cell, vol. 8, no. 1, Jul. 2001, pp. 57-69. https://doi.org/10.1016/S1097-2765(01)00283-0
  5. N.A. Barlev, L. Liu, N.H. Chehab, K Mansfield, K.G. Harris, T.D. Halazonetis, et al., "Acetylation of p53 activates transcription tlrrough recruitment of coactivatorsihistone acetyltransferases," Mol.Cell, vol. 8, no. 6, Dec. 2001, pp. 1243-1254. https://doi.org/10.1016/S1097-2765(01)00414-2
  6. S.L. Berger, "Histone modifications in transcriptional regnlation," Curr.Opin.Genet.Dev., vol. 12, no. 2, Apr. 2002, pp.142-148. https://doi.org/10.1016/S0959-437X(02)00279-4
  7. J.M. Espinosa, R.E. Verdun, and B.M. Emerson, "p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage," Mol.Cell, vol. 12, no. 4, Oct. 2003, pp.1015-1027. https://doi.org/10.1016/S1097-2765(03)00359-9
  8. S. Nagar, L.E. Smith, and W.F. Morgan, "Characterization of a novel epigenetic effect of ionizing radiation: the death-inducing effect," Cancer Res., vol. 3, no. 2, Jan. 2003, pp. 324-328.
  9. W. An, J. Kim, and R.G. Roeder, "Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53," Cell, vol. 117, no. 6, Jun. 2004, pp. 735-748. https://doi.org/10.1016/j.cell.2004.05.009
  10. A. Taddei, D. Roche, W.A. Bickmore, and G. Almouzni, "The effects of histone deacetylase inhibitors on heterochromatin: implications for anticancer therapy?" EMBO rep., vol. 6, no. 6, Jun. 2005, pp. 520-524. https://doi.org/10.1038/sj.embor.7400441
  11. A. Lennartsson, and K. Ekwall, "Histone modification patterns and epigenetic codes," Biochim.Biophys.Acta, vol. 1790, no. 9, Sep. 2009, pp. 863-868. https://doi.org/10.1016/j.bbagen.2008.12.006
  12. A. Kumar, P.S. Rai, R. Upadhya, Vishwanatha, K.S. Prasada, B.S.S. Rao, et al., "$\gamma$-radiation induces cellular sensitivity and aberrant methylation in human tumor cell lines," Int.J.Radiat.Biol., vol. 87, no. 11, Nov. 2011, pp. 1086-1096. https://doi.org/10.3109/09553002.2011.605417