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Serum Levels of Alpha-Tocopherol, Vitamin C, Beta-Carotene, and Retinol in Malignant Pleural Mesothelioma

  • Emri, Salih (Department of Chest Disease, Hacettepe University Faculty of Medicine) ;
  • Kilickap, Saadettin (Department of Medical Oncology, Cumhuriyet University Faculty of Medicine) ;
  • Kadilar, Cem (Department of Biostatistics, Hacettepe University Faculty of Medicine) ;
  • Halil, Meltem Gulhan (Department of Internal Medicine, Hacettepe University Faculty of Medicine) ;
  • Akay, Hadi (Department of Chest Surgery, Ankara University Medical Faculty) ;
  • Besler, Tanju (School of Health Technology, Hacettepe University)
  • 발행 : 2012.07.31

초록

The aim of this study was to investigate the possible relationship between antioxidant vitamin levels and malignant pleural mesothelioma (MPM). For this purpose, we measured the serum levels of 4 antioxidant vitamins, ${\beta}$-carotene, ${\alpha}$-tocopherol, retinol, and ascorbic acid, in patients with environmentally induced MPM and in healthy controls from one tremolite village (Kureysler), the biggest erionite village (Tuzkoy) and Ankara. A total of 160 subjects were enrolled in the study, 42 (26.3%) diagnosed with MPM and 118 (73.7%) healthy subjects. A comparison was made between the MPM group and three control groups of which two were exposed and one was unexposed to mineral fibers. The study population consisted of 82 males (51%) and 78 females (49%) with a mean of age of $44.8{\pm}14$ years (range; 20-65 years). Lowest levels of ${\beta}$-carotene, ascorbic acid, and ${\alpha}$-tocopherol were found in MPM patients (MPM vs control groups combined, p<0.0001 for each antioxidant vitamin), without any relation to age or sex. There was no significant difference between the antioxidant levels of healthy controls of Tuzkoy and Ankara. In conclusion; our findings suggested an increased risk of MPM being associated with low levels of ${\alpha}$-tocopherol and ascorbic acid in patients with MPM.

키워드

참고문헌

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피인용 문헌

  1. Intravenous Vitamin C for Cancer Therapy – Identifying the Current Gaps in Our Knowledge vol.9, pp.1664-042X, 2018, https://doi.org/10.3389/fphys.2018.01182