Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)
- Volume 44 Issue 4
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- Pages.229-238
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- 2012
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- 1738-3544(pISSN)
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- 2288-1662(eISSN)
Cyclooxygenase-2 over-expression is associated with increased mast cells in CCl4-induced hepatic fibrosis
- Jekal, Seung-Joo (Department of Clinical Laboratory Science, Wonkwang Health Science University) ;
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Lee, Jae-Hyoung
(Department of Physical Therapy, Wonkwang Health Science University) ;
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Park, Seung-Teack
(Department of Anatomy, College of Medicine, Wonkwang University)
- Received : 2012.11.29
- Accepted : 2012.12.14
- Published : 2012.12.30
Abstract
Cyclooxygenase(COX-2) is an inducible enzyme that catalyzes the synthesis of prostaglandins (PGs) from arachidonic acid. Over-expression of COX-2 has been reported to be associated with progressive hepatic fibrosis in chronic hepatic C infection and rat liver fibrosis induced by carbon tetrachloride(