Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Effect of Hemiplegia Induced by Sciatic Nerve Injury on both Tibia Trabecular Bone of C57BL/6 Mouse

궁둥신경손상으로 인한 하지의 편마비가 양측 정강 뼈 해면골에 미치는 영향

  • Jung, Young Jin (Department of Biomedical Engineering & Yonsei Fraunhofer IZFP Medical Device Lab, Yonsei University) ;
  • Seo, Dong Hyeon (Department of Biomedical Engineering & Yonsei Fraunhofer IZFP Medical Device Lab, Yonsei University) ;
  • Kim, Han Sung (Department of Biomedical Engineering & Yonsei Fraunhofer IZFP Medical Device Lab, Yonsei University) ;
  • Ko, Chang-Yong (Research Team, Korea Orthopedics & Rehabilitation Engineering Center)
  • 정영진 (연세대학교 보건과학대학 의공학과 & 프라운호퍼 의료기기 공동연구센터) ;
  • 서동현 (연세대학교 보건과학대학 의공학과 & 프라운호퍼 의료기기 공동연구센터) ;
  • 김한성 (연세대학교 보건과학대학 의공학과 & 프라운호퍼 의료기기 공동연구센터) ;
  • 고창용 (재활공학연구소 연구실)
  • Received : 2012.09.26
  • Accepted : 2012.11.07
  • Published : 2012.12.31
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Abstract

It is widely known that sciatic nerve injury (SNI) can negatively affect the biomechanical characteristics of the musculoskeletal system. However, there were no studies that evaluated and compared denervated side with another side limb at the same time. In this study, sixteen male 12-week-old mice were allocated into two groups: HEMI (Right Sciatic nerve denervated) and CON (Control). Both limbs were scanned using micro-CT at 0 week and 4 weeks. There were significant differences in relative variation (RV) of BMD and all structural parameters compared CON and HEMI in right tibia (p < 0.05). Tb.Th and Tb.Sp distributions were differed CON with HEMI in right tibia. In left tibia, there were significant differences in RV of BMD (p < 0.05) and Tb.Sp distribution. These result means that SNI can induce bone loss in the both side tibiae. However, there was a different profile of bone loss between left and right tibiae.

Keywords

References

  1. F.J. Villarejo and A.M. Pascual, "Injection injury of the sciatic nerve (370 cases)." Childs Nerv Syst., vol. 9, no. 4, pp. 229-232, 1993. https://doi.org/10.1007/BF00303575
  2. J.L. Walker, J.M. Evans, P. Meade, P. Resig and B.F. Sisken, "Gait-stance duration as a measure of injury and recovery in the rat sciatic nerve model." Journal of Neuroscience Methods., vol. 52, pp. 47-52, 1994. https://doi.org/10.1016/0165-0270(94)90054-X
  3. H.M. Frost, "Bone's Mechanostat: A 2003 Update." The Anatomical Record Part A, vol. 275A, pp. 1081-1101, 2003. https://doi.org/10.1002/ar.a.10119
  4. O.M. Pearson and D.E. Lieberman, The Aging of Wolff's "Law": Ontogeny and Responses to Mechanical Loading in Cortical Bone, Yearbook of Physical Anthropology vol. 47, pp. 63-99, 2004.
  5. S. Judex, X. Lei, D. Han and C. Rubin, "Low-magnitude mechanical signals that stimulate bone formation in the ovariectomized rat are dependent on the applied frequency but not on the strain magnitude." J Biomech, vol. 40, pp. 1333- 1339, 2007. https://doi.org/10.1016/j.jbiomech.2006.05.014
  6. D.H. Seo, C.Y. Ko, S.Y. Kang, D.H. Lim and H.S. Kim, "Effects of Unloading induced Denervation on Trabecular Bone of Growing Mice." Journal of the Korean Society for Precision Engineering, vol. 26, no. 10, pp. 122-128, 2009.
  7. C.Y. Ko, D.H. Seo and H.S. Kim, "Deterioration of Bone Quality in the Tibia and Fibula in Growing Mice During Skeletal Unloading: Gender-Related Differences." Journal of Biomechanical Engineering, vol. 133, pp. 111003-1-111003- 8, 2011. https://doi.org/10.1115/1.4005350
  8. C.Y. Ko, Y.J. Jung, D.H. Seo, J. Schreiber, D.H Lim and H.S. Kim, "Trabecular Bone Loss in Lumbar Vertebrae and Tibiae following Sciatic Nerve Injury: Correlation between Baseline Bone Quantity (BV/TV) and the Magnitude and Rate of Bone Loss." International Journal of Precision Engineering and Manufacturing, vol. 13, no. 9, pp. 1705-1708, 2012. https://doi.org/10.1007/s12541-012-0223-z
  9. H. Suyama, K. Moriwaki, S. Niida, Y. Maehara, M. Kawamoto and O. Yuge, "Osteoporosis following chronic constriction injury of sciatic nerve in rats." J Bone Miner Metab, vol. 20, pp. 91-97, 2002. https://doi.org/10.1007/s007740200012
  10. N. Suzue, T. Nikawa, Y. Onishi, C. Yamada , K. Hirasaka, T. Ogawa, H. Furochi, H. Kosaka, K. Ishidoh, H. Gu and others, "Ubiquitin ligase Cbl-b downregulates bone formation through suppression of IGF-I signaling in osteoblasts during denervation." J Bone Miner Res, vol. 21, no. 5, pp. 722-734, 2006. https://doi.org/10.1359/jbmr.060207
  11. J. Iwamoto, T. Takeda, T. Katsumata, T. Tanaka, S. Ichimura and Y. Toyama, "Effect of etidronate on bone in orchidectomized and sciatic neurectomized adult rats." Bone, vol. 30, no. 2, pp. 360-367, 2002. https://doi.org/10.1016/S8756-3282(01)00687-1
  12. S.D. Jiang, L.S. Jiang and L.Y. Dai, "Spinal cord injury causes more damage to bone mass, bone structure, biomechanical properties and bone metabolism than sciatic neurectomy in young rats." Osteoporosis International, vol. 17, no. 10, pp. 1552-1561, 2006. https://doi.org/10.1007/s00198-006-0165-3
  13. C. Chenu, "Role of innervation in the control of bone remodeling." J Musculoskelet Neuronal Interact, vol. 4, no. 2, pp. 132-134, 2004.
  14. S.J. Sample, M. Behan, L. Smith, W.E. Oldenhoff, M.D. Markel, V.L. Kalscheur, Z. Hao, V. Miletic and P. Muir, "Functional adaptation to loading of a single bone is neuronally regulated and involves multiple bones." J. Bone Miner Res, vol. 23, pp. 1372-1381, 2008. https://doi.org/10.1359/jbmr.080407
  15. S.J. Sample, R.J. Collins, A.P. Wilson, M.A. Racette, M. Behan, M.D. Markel, V.L. Kalscheur, Z. Hao and P. Muir, "Systemic effects of ulna loading in male rats during functional adaptation." J. Bone Miner Res, vol. 25, pp. 2016- 2028, 2010. https://doi.org/10.1002/jbmr.101
  16. N.G Burke, M. Walsh, T. O'Brien and K. Synnott, "Diagnostic gait pattern of a patient with longstanding left femoral nerve palsy: a case report." Journal of Orthopaedic Surgery, vol. 18, no. 3, pp. 382-384, 2010. https://doi.org/10.1177/230949901001800327
  17. C.Y. Ko, D.H. Seo, H.S. Kim, H.S. Kim, S.H. Kim, J.M. Kim, K.W. Kim and D.H. Lim, "Suppression of Osteoporotic bone loss on the site to which low Intensity Ultrasound is Irradiated - In vivo test on BMD and Morphological Characteristics." Journal of Biomedical Engineering Research, Vol. 30, No. 1, pp. 49-55, 2009.
  18. Q.Q. Zeng, W.S. Jee, A.E. Bigornia, J.G.Jr. King, S.M. D'Souza, X.J. Li, Y.F. Ma, W.J. Wechter, "Time Responses of Cancellous and Cortical Bones to Sciatic Neurectomy in Growing Female Rats." Bone, vol. 19, no. 1, pp. 13-21, 1996. https://doi.org/10.1016/8756-3282(96)00112-3
  19. C. Chenu, "Role of Innervation in the Control of Bone Remodeling." J Musculoskelet Neuronal Interact, vol. 4, no. 2, pp. 132-134, 2004.
  20. S.D. Jiang, L.S. Jiang and L.Y. Dai, "Mechanisms of Osteoporosis in Spinal Cord Injury." Clin Endocrinol (Oxf), vol. 65, no. 5, pp. 555-565, 2006. https://doi.org/10.1111/j.1365-2265.2006.02683.x
  21. R. Jancalek, P. Dubovy, I. Svizenska and I. Klusakova, "Bilateral changes of TNF-${\alpha}$ and IL-10 protein in the lumbar and cervical dorsal root ganglia following a unilateral chronic constriction injury of the sciatic nerve." Journal of Neuroinflammation, vol. 7, no. 11, pp. 2-9, 2010. https://doi.org/10.1186/1742-2094-7-2
  22. T.H Huang, H.S Lin and H.I Chen, "The effects of systemic chemical sympathectomy on local bone loss induced by sciatic neurectomy." J Orthop Sci, vol. 16, pp. 629-637, 2011. https://doi.org/10.1007/s00776-011-0117-4