Asian Pacific Journal of Cancer Prevention

  • 제13권9호
  • /
  • Pages.4823-4826
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  • 2012
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Clinical Predictive Value of Serum Angiogenic Factor in Patients with Osteosarcoma

  • Chen, Zhe (Department of Orthopaedics, The Second Affiliated Hospital, Medical College, Zhejiang University) ;
  • Chen, Qi-Xin (Department of Orthopaedics, The Second Affiliated Hospital, Medical College, Zhejiang University) ;
  • Hou, Zhao-Yang (Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang Chinese Medical University) ;
  • Hu, Jiong (Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang Chinese Medical University) ;
  • Cao, Yan-Guang (Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang Chinese Medical University)
  • 발행 : 2012.09.30
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초록

Objective: To explore serum angiogenic factor expression in patients with osteosarcoma and its relationship with metastasis. Methods: Immunohistochemistry was used to test the expression of CD34 and FVIII-Rag in osteosarcoma tissues of 36 patients (osteosarcoma group) and microvessel density (MVD) was also recorded. In addition, ELISA was used to test the level of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), transforming growth factor-${\beta}1$ (TGF-${\beta}1$) and endostatin (ES) in the osteosarcoma group and in a control group. Results: VEGF and ES level were significantly higher than in the control group before operation (P<0.01), VEGF, bFGF and TGF-${\beta}1$ correlating with the ES level (P<0.01). Serum VEGF and ES levels of osteosarcoma patients before surgery were closely related to relapse and metastasis; moreover, serum VEGF increased with MVD (P<0.01). Postoperative VEGF and ES levels were lower than the preoperation values (P<0.01); ES level in relapse group was significantly higher than that of the non-relapse group (P<0.01). Conclusion: Preoperative serum VEGF and postoperative ES levels have great predictive value with regard to relapse of osteosarcoma patients.

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참고문헌

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피인용 문헌

  1. Benzochloroporphyrin Derivative Induced Cytotoxicity and Inhibition of Tumor Recurrence During Photodynamic Therapy for Osteosarcoma vol.14, pp.5, 2013, https://doi.org/10.7314/APJCP.2013.14.5.3351
  2. A systematic review of vascular endothelial growth factor expression as a biomarker of prognosis in patients with osteosarcoma vol.34, pp.3, 2013, https://doi.org/10.1007/s13277-013-0733-z
  3. Apurinic/apyrimidinic endonuclease 1 regulates angiogenesis in a transforming growth factor β-dependent manner in human osteosarcoma vol.106, pp.10, 2015, https://doi.org/10.1111/cas.12763
  4. Improved Survival in Osteosarcoma Patients with Atypical Low Vascularization vol.22, pp.2, 2015, https://doi.org/10.1245/s10434-014-4001-2
  5. High-level expression of periostin is significantly correlated with tumour angiogenesis and poor prognosis in osteosarcoma vol.97, pp.1, 2016, https://doi.org/10.1111/iep.12171
  6. Prognostic impact of blood and urinary angiogenic factor levels at diagnosis and during treatment in patients with osteosarcoma: a prospective study vol.17, pp.1, 2017, https://doi.org/10.1186/s12885-017-3409-z
  7. Blood-borne biomarkers of osteosarcoma: A systematic review pp.15455009, 2018, https://doi.org/10.1002/pbc.27462