Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Functional Analysis of B7-H3 in Colonic Carcinoma Cells

  • Lu, Peng (Department of Oncological Surgery, People's Hospital of Zhengzhou) ;
  • Liu, Rong (Academician Experts Workstation of Henan Province, People's Hospital of Zhengzhou) ;
  • Ma, Er-Min (Department of Oncological Surgery, People's Hospital of Zhengzhou) ;
  • Yang, Tie-Jian (Department of Oncological Surgery, People's Hospital of Zhengzhou) ;
  • Liu, Jia-Lin (Department of Oncological Surgery, People's Hospital of Zhengzhou)
  • Published : 2012.08.31
Download PDF
⟨ Previous Next ⟩

Abstract

B7-H3 is a newly discovered member of the B7/CD28 superfamily which functions as an important T-cell immune molecule. It has been reported recently that B7-H3 is highly expressed in many cancer cells, the data indicating that it may be a regulation factor contributing to tumor-resistance. In our study, we used bioinformatics to identify differentially expressed genes between colonic cancer cells and normal colonic cells, aiming to analyze mechanisms and identify sub-pathways closely related to progression, with the final aim of finding small molecule drugs which might interfere this progression. We found that ajmaline is one related factor which may enhance self-immunity in colon carcinoma therapy and B7-H3 plays important roles with regard to immunoreactions of colonic cancer cells. All the results indicate that H7-B3 is a favorable prognostic biomarker for colon carcinomas, providing novel information regarding likely targets for intervention.

Keywords

References

  1. Ahmed BA (2010). Awareness and practice of breast cancer and breast-self examination among university students in Yemen. Asian Pac J Cancer Prev, 11, 101.
  2. Arigami T, Narita N, Mizuno R, et al (2010). B7-h3 ligand expression by primary breast cancer and associated with regional nodal metastasis. Ann Surg, 252, 1044-51. https://doi.org/10.1097/SLA.0b013e3181f1939d
  3. Arigami T, Uenosono Y, Hirata M, et al (2011). B7-H3 expression in gastric cancer: a novel molecular blood marker for detecting circulating tumor cells. Cancer Sci, 102, 1019-24. https://doi.org/10.1111/j.1349-7006.2011.01877.x
  4. Biglarian A, Hajizadeh E, Kazemnejad A, Zayeri F (2010). Determining of prognostic factors in gastric cancer patients using artificial neural networks. Asian Pac J Cancer Prev, 11, 533-6.
  5. Chapoval AI, Ni J, Lau JS, et al (2001). B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat Immunol, 2, 269-74. https://doi.org/10.1038/85339
  6. Du DS, Ma XB, Zhang JF, et al (2010). The protective effect of capsaicin receptor-mediated genistein postconditioning on gastric ischemia-reperfusion injury in rats. Dig Dis Sci, 55, 3070-7. https://doi.org/10.1007/s10620-010-1151-3
  7. Han MA, Choi KS, Park JH, Moore MA, Park EC (2011). Midcourse Evaluation of the Second-term 10-year Plan for Cancer Control in Korea. Asian Pac J Cancer Prev, 12, 327-33.
  8. Huang da W, Sherman BT, Lempicki RA (2009). Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res, 37, 1-13. https://doi.org/10.1093/nar/gkn923
  9. Huang da W, Sherman BT, Lempicki RA (2009). Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc, 4, 44-57. https://doi.org/10.1038/nprot.2008.211
  10. Ingebrigtsen VA, Boye K, Tekle C, et al (2012). B7-H3 expression in colorectal cancer: Nuclear localization strongly predicts poor outcome in colon cancer. Int J Cancer. doi: 10.1002/ijc.27566.
  11. Irizarry RA, Hobbs B, Collin F, et al (2003). Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics, 4, 249-64. https://doi.org/10.1093/biostatistics/4.2.249
  12. Lamb J, Crawford ED, Peck D, et al (2006). The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science, 313, 1929-35. https://doi.org/10.1126/science.1132939
  13. Liu HT, Du YG, He JL, et al (2010). Tetramethylpyrazine inhibits production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through blockade of MAPK and PI3K/Akt signaling pathways, and suppression of intracellular reactive oxygen species. J Ethnopharmacol, 129, 335-43. https://doi.org/10.1016/j.jep.2010.03.037
  14. Liu YT, Gao CM, Ding JH, et al (2011). Physiological, reproductive factors and breast cancer risk in jiangsu province of china. Asian Pac J Cancer Prev, 12, 787-90.
  15. Liu YX, Wang B, Wan MH, et al (2011). Meta-analysis of the Relationship between the Metholenetetrahydrofolate Reductase C677T Genetic Polymorphism, Folate Intake and Esophageal Cancer. Asian Pac J Cancer Prev, 12, 247-52.
  16. Lupu CM, Eisenbach C, Kuefner MA, et al (2006). An orthotopic colon cancer model for studying the B7-H3 antitumor effect in vivo. J Gastrointest Surg, 10, 635-45. https://doi.org/10.1007/BF03239969
  17. Modi S, Stopeck AT, Gordon MS, et al (2007). Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation study. J Clin Oncol, 25, 5410-7. https://doi.org/10.1200/JCO.2007.11.7960
  18. Nygren MK, Tekle C, Ingebrigtsen VA, Fodstad O (2011). B7-H3 and its relevance in cancer; immunological and non-immunological perspectives. Front Biosci (Elite Ed), 3, 989-93.
  19. Pourhoseingholi MA, Fazeli Z, Zali MR, Alavian SM (2010). Burden of hepatocellular carcinoma in Iran; Bayesian projection and trend analysis. Asian Pac J Cancer Prev, 11, 859-62.
  20. Roth TJ, Sheinin Y, Lohse CM, et al (2007). B7-H3 ligand expression by prostate cancer: a novel marker of prognosis and potential target for therapy. Cancer Res, 67, 7893-900. https://doi.org/10.1158/0008-5472.CAN-07-1068
  21. Saatian B, Yu XY, Lane AP, et al (2004). Expression of genes for B7-H3 and other T cell ligands by nasal epithelial cells during differentiation and activation. Am J Physiol Lung Cell Mol Physiol, 287, L217-25. https://doi.org/10.1152/ajplung.00132.2003
  22. Smyth GK (2004). Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Statistical applications in genetics and molecular biology, 3, Article3.
  23. Shin HR, Masuyer E, Ferlay J, et al (2010). Cancer in Asia- Incidence rates based on data in cancer incidence in five continents IX (1998-2002). Asian Pac J Cancer Prev, 11, 11-6.
  24. Sun Y, Wang Y, Zhao J, et al (2006). B7-H3 and B7-H4 expression in non-small-cell lung cancer. Lung Cancer, 53, 143-51. https://doi.org/10.1016/j.lungcan.2006.05.012
  25. Sundarraj S, Kannan S (2010). Immunohistochemical expression of cytosolic phospholipase $A2{\alpha}$ in non-small cell lung carcinoma. Asian Pac J Cancer Prev, 11, 1367-72.
  26. Tang XD, Zhou X, Zhou KY (2009). Dauricine inhibits insulinlike growth factor-I-induced hypoxia inducible factor 1alpha protein accumulation and vascular endothelial growth factor expression in human breast cancer cells. Acta Pharmacol Sin, 30, 605-16. https://doi.org/10.1038/aps.2009.8
  27. Team RDC (2008). R: A language and environment for statistical computing. R Foundation for Statistical Computing.
  28. Vaishampayan UN, Burger AM, Sausville EA, et al (2010). Safety, efficacy, pharmacokinetics, and pharmacodynamics of the combination of sorafenib and tanespimycin. Clin Cancer Res, 16, 3795-804. https://doi.org/10.1158/1078-0432.CCR-10-0503
  29. Xu YH, Zhang GB, Wang JM, Hu HC (2010). B7-H3 and CD133 expression in non-small cell lung cancer and correlation with clinicopathologic factors and prognosis. Saudi Med J, 31, 980-6.
  30. Yang HY, Chu M, Zheng LW, et al (2008). Transgenic B7-H3 therapy induces tumor-specific immune response in human oral squamous cell cancer: an in vitro study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 106, 721-8. https://doi.org/10.1016/j.tripleo.2008.08.012
  31. Yuan H, Wei X, Zhang G, et al (2011). B7-H3 over expression in prostate cancer promotes tumor cell progression. J Urol, 186, 1093-9. https://doi.org/10.1016/j.juro.2011.04.103
  32. Zang X, Thompson RH, Al-Ahmadie HA, et al (2007). B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome. Proc Natl Acad Sci USA, 104, 19458-63. https://doi.org/10.1073/pnas.0709802104
  33. Zhong W, Zou G, Gu J, Zhang J (2010). L-arginine attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells. Diabetes Res Clin Pract, 89, 38-45. https://doi.org/10.1016/j.diabres.2010.03.013

Cited by

  1. Down-regulated MYH11 Expression Correlates with Poor Prognosis in Stage II and III Colorectal Cancer vol.15, pp.17, 2014, https://doi.org/10.7314/APJCP.2014.15.17.7223
  2. B7-H3 protein expression in a murine model of osteosarcoma vol.12, pp.1, 2016, https://doi.org/10.3892/ol.2016.4675