Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Model Systems in Radiation Biology: Implication for Preclinical Study of Radiotherapy

방사선 생물학을 위한 모델 시스템: 방사선치료의 전임상 연구

  • Kim, Wanyeon (Department of Biological Sciences, College of Natural Sciences, Pusan National University) ;
  • Seong, Ki Moon (Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd.) ;
  • Yang, Hee Jung (Department of Biological Sciences, College of Natural Sciences, Pusan National University) ;
  • Youn, HyeSook (Department of Bioscience & Biotechnology/Institute of Bioscience, Sejong University) ;
  • Youn, BuHyun (Department of Biological Sciences, College of Natural Sciences, Pusan National University)
  • 김완연 (부산대학교 자연과학대학 생명과학과) ;
  • 성기문 ((주)한국수력원자력 방사선보건연구원 영향연구팀) ;
  • 양희정 (부산대학교 자연과학대학 생명과학과) ;
  • 윤혜숙 (세종대학교 생 명과학대학 생명공학부 생명공학과) ;
  • 윤부현 (부산대학교 자연과학대학 생명과학과)
  • Received : 2012.09.19
  • Accepted : 2012.11.15
  • Published : 2012.11.30
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Abstract

In radiation biology, analysis of various mechanisms in response to radiation has been accomplished with the use of model organisms. These model organisms are powerful tools for providing a biologically intact in vivo environment to assess physiological and pathophysiological processes affected by radiation. Accumulated data using these models have been applied to human clinical studies (including the evaluation of radiotherapeutic efficacy) and discovery of radiotherapy reagents. However, there are few studies to provide overall integrated information about these useful model organisms. Thus, this review summarizes the results of radiation biology studies using four well-known model organisms: yeast, Caenorhabditis elegans, Drosophila melanogaster, and mice.

방사선 생물학에서 방사선에 대한 반응으로 매개되는 다양한 기작에 대한 분석을 위해 여러 종류의 모델 생물체를 사용해 왔다. 모델 생물체는 생물학적으로 온전한 in vivo 환경을 제공할 수 있기 때문에 방사선에 의해 발생되는 세포 내 현상은 물론 생리적인 현상이나 병리학적인 현상을 규명하는 데 있어서 모델 생물체를 사용하는 것은 효과적인 방법이 될 수 있다. 지금까지 축적된, 모델 생물체를 이용한 방사선 생물학적 연구결과들은 새로운 방사선치료 보조제의 개발, 방사선치료 효율 증진 등에 적용되어 여러 질병에 대한 임상연구의 기초가 되어왔다. 이렇게 유용하게 사용된 여러 모델 생물체에 있어서, 각각의 모델에 대한 개별적인 정보에 대한 연구는 다양한 방면에서 이루어지고 있지만, 통합적인 비교, 분석 및 정리를 한 경우는 부족한 실정이다. 따라서, 본 논문에서는 방사선 생물학에서 지금까지 많이 사용된 모델 생물체 4종(효모, 예쁜꼬마선충, 초파리, 생쥐)에 대해 각 생물체가 갖는 모델로써의 특징과 장단점 그리고 방사선 생물학 연구에 이용된 사례 등을 서술하고자 한다.

Keywords

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