Bisphosphonate related osteonecrosis of jaw

비스포스포네이트(Bisphosphonate)를 복용하는 환자에서 발생하는 골괴사증

  • Hwang, Kyung-Gyun (Oral & Maxillofacial Surgery, Department of Dentistry, Collage of Medicine, Hanyang University)
  • 황경균 (한양대학교 의과대학 치과학교실 구강악안면외과)
  • Published : 2011.07.01

Abstract

Bisphosphonates are widely used in the management of osteoporosis patients. Many reports and clinical studies have published a relationship between necrotic bone lesions localized to the jaw and the use of chronic bisphosphonate therapy. This osteonecrosis named bisphosphonate-related osteonecrosis of the jaw(BRONJ). This article described the mechanism, chemical structure, indication, risk factor of the bisphosphonate.

Keywords

References

  1. Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg 2003: 61: 1115-1117. https://doi.org/10.1016/S0278-2391(03)00720-1
  2. Fleisch H. Bisphosphonates: mechanisms of action. Endocr Rev 1998: 19: 80-100. https://doi.org/10.1210/er.19.1.80
  3. Fleisch H. Development of bisphosphonates. Breast Cancer Res 2002: 4: 30-34. https://doi.org/10.1186/bcr487
  4. Green J, Clezardin P. The molecular basis of bisphosphonate activity: a preclinical perspective. Semin Oncol 2010: 37 Suppl 1: S3-11. https://doi.org/10.1053/j.seminoncol.2010.06.003
  5. Rondeau JM, Bltsch F, Bourgier E. et al. Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs. ChemMedChem 2006: 1: 267-273. https://doi.org/10.1002/cmdc.200500059
  6. Green JR. Bisphosphonates: preclinical review. Oncologist 2004: 9 Suppl 4: 3-13.
  7. Ruggiero SL, Dodson TB, Assael LA, Landesberg R, Marx RE, Mehrotra B. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws--2009 update. J Oral Maxillofac Surg 2009: 67: 2-12.
  8. Gibbs SD, O'Grady J, Seymour JF. Prince HM. Bisphosphonate-induced osteonecrosis of the jaw requires early detection and intervention. Med J Aust 2005: 183: 549-550.
  9. Nase JB, Suzuki JR Osteonecrosis of the jaw and oral bisphosphonate treatment. J Am Dent Assoc 2006: 137: 1115-1119; quiz 1169-1170. https://doi.org/10.14219/jada.archive.2006.0350
  10. Kanat O, Ozet A, Ataergin S, et al. Bisphosphonate treatment as a cause of jaw osteonecrosis. Oral Dis 2007: 13: 346-347. https://doi.org/10.1111/j.1601-0825.2007.01320.x
  11. Infante Cossio P, Cabezas Macian A, Perez Ceballos JL. Palomino Nicas J. Gutierrez Perez JL. Bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma. Med Oral Patol Oral Cir Bucal 2008: 13: E52-57.
  12. Ruggiero SL, Mehrotra B. Bisphosphonate-related osteonecrosis of the jaw: diagnosis, prevention. and management. Annu Rev Med 2009: 60: 85-96. https://doi.org/10.1146/annurev.med.60.063007.134350