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에키네시아 조직 배양체 추출물의 생리활성에 관한 연구

Study on Biological Activities of Adventitious Roots Cultured from Echinacea angustifolia

  • 박창민 ((주)한국화장품제조 기술개발연구소) ;
  • 정민석 ((주)한국화장품제조 기술개발연구소) ;
  • 고두진 ((주)한국화장품제조 기술개발연구소) ;
  • 백기엽 (충북대학교) ;
  • 최종완 ((주)한국화장품제조 기술개발연구소)
  • Park, Chang-Min (R&D Center, Hankook Cosmetics Manufacturing Co., Ltd.) ;
  • Joung, Min-Seok (R&D Center, Hankook Cosmetics Manufacturing Co., Ltd.) ;
  • Ko, Du-Jin (R&D Center, Hankook Cosmetics Manufacturing Co., Ltd.) ;
  • Paek, Kee-Yoeup (Research Center for The Development of Advanced Horticultural Technology, Chungbuk National University) ;
  • Choi, Jong-Wan (R&D Center, Hankook Cosmetics Manufacturing Co., Ltd.)
  • 투고 : 2011.07.29
  • 심사 : 2011.09.19
  • 발행 : 2011.09.30

초록

일반적으로 쌍떡잎식물 국화과 허브의 한 종인 에키네시아는 미국 북미 대평원에 서식하는 야생 식물로 수세기 동안 감기나 또 다른 바이러스 감염에 의한 질병에 대하여 면역 기능을 증진시키는 전통 식물 약제로 널리 사용되어왔다. 본 연구에서는 생물반응장치를 이용하여 조직 배양된 에키네시아 식물체에 대하여 화장품 성분으로써 응용 가치를 평가하였다. 이미 몇몇 보고된 논문에서 에키네시아는 조직재생, 상처 치유, 그리고 염증 억제 등의 약리학적 활성에 대한 연구가 진행되었다. 본 연구에서는 생물반응장치를 이용하여 조직 배양된 에키네시아 추출물에 대하여 화장품 성분으로서 효능, 효과를 평가하였다. 실험 결과 조직배양된 에키네시아 추출물은 항산화 효과 및 단백분해효소 발현 억제 효과가 자연 상태의 에키네시아 추출물과 비교하여 우수한 결과를 보였다. 이러한 결과들은 피부보호를 위한 화장품 성분으로서 응용 가능성을 제공할 수 있을 것으로 사료된다.

The Echinacea, which has been commonly known as a species of composite herb of dicotyledonous plant, has been used in native American traditional medicine for the treatment of diseases like colds or other infections in North America. We artificially cultured the adventitious roots of Echinacea angustifolia using the bioreactor culture system from Echinacea angustifolia and evaluated the efficacy as a cosmetic ingredient for skin care. Several studies previously have reported neogenesis, wound healing and inflammatory inhibition effect of Echinacea angustifolia but other efficacies were not well known. In the present study, we investigated the cosmetic efficacy to know applicable value of adventitious roots cultured from Echinacea angustifolia as a cosmetic ingredient. The adventitious roots extract of Echinacea angustifolia has superior anti-oxidant effect and matrix metalloproteinase-2 inhibitory effect, compared to natural Echinacea angustifolia. These results indicate that the adventitious roots extract cultured from Echinacea angustifolia presents a new possibility of being applicable to skin care and anti-wrinkle products as a cosmetic ingredient.

키워드

참고문헌

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