동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제25권5호
  • /
  • Pages.876-880
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  • 2011
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  • 1738-7698(pISSN)
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  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

Antidepressant Effects of Gammakdaejo-Tang on Repeated Immobilization Stress in the Ovariectomized Female Rats

  • Park, Hyun-Jung (Acupuncture and Meridian Science Research Center, Kyung Hee University) ;
  • Shim, Hyun-Soo (Acupuncture and Meridian Science Research Center, Kyung Hee University) ;
  • Lee, Hye-Jung (Acupuncture and Meridian Science Research Center, Kyung Hee University) ;
  • Yun, Young-Ju (Department of Integrative Medicine, School of Korean Medicine, Pusan National University) ;
  • Shim, In-Sop (Acupuncture and Meridian Science Research Center, Kyung Hee University)
  • 투고 : 2011.09.20
  • 심사 : 2011.10.18
  • 발행 : 2011.10.25
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초록

Gammakdaejo-Tang (GMT) is a traditional oriental medicinal formula, a mixture of 3 crude drugs, and it has been clinically used for treating mild depressive disorders. The purpose of the study was to examine the effect of Gammakdaejo-Tang (GMT) on repeated stress-induced alterations of learning and memory on a passive avoidance test (PAT) test and also the anxiety-related behavior on the elevated pulse maze (EPM) in ovariectomized female rats. We assessed the changes in the reactivity of the cholinergic system by measuring the immunoreactive neurons of choline acetyltransferase (ChAT) in the hippocampus after behavioral testing. The rats were exposed to the immobilization (IMO) stress for 14 days (2hours/day), and Gammakdaejo-Tang (400 mg/kg, p.o.) was administered 30 min before IMO stress. Treatments with GMT caused significant reversals of the stress-induced deficits in learning and memory on a working memory test, and it also produced an anxiolytic-like effect on the EPM, and increased the ChAT reactivities (p<0.001, respectively). These results suggest that Gammakdaejo-Tang might prove to be an effective antidepressant agent.

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참고문헌

  1. Murthy, R.S., Bertolote, J.M., Jordan, A.E., Funk, M., Prentice, T., Saraceno, B., Saxena, S. Mental health new understanding, The world health report 2001, Geneva, Switzerland, World health organization. pp 64-66, 2001.
  2. Lucki I. The forced swimming test as a model for core and components bahavioral effects of antidepressant drugs: Bahavioral Pharmacology 8: 523-532, 1997. https://doi.org/10.1097/00008877-199711000-00010
  3. Porsolt, R.D., Le Pichon, M., Jalfre, M. The depressiona new animal model sensitive to antidepressant treatments: Nature 266: 730-732, 1977. https://doi.org/10.1038/266730a0
  4. Borsini, F., Meli, A. Is the forced swimming test a suitable model for revealing antidepressant activity?: Psychopharmacology 94: 147-160, 1988.
  5. Cryan, J.F., Markou, A., Lucki, I. Assessing antidepressant activity in rodents: recent developments and future needs: Trends in Pharmacological Sciences 23: 238-245, 2002. https://doi.org/10.1016/S0165-6147(02)02017-5
  6. Tamminga, D.A., Nemeroff, C.B., Blakely, R.D., Brady, L., Carter, C.S., Davis, K.L. Developing novel treatments for mood disorders: Accelerating discovery: Biological Psychiatry 52: 589-609, 2002. https://doi.org/10.1016/S0006-3223(02)01470-1
  7. Adell, A., Castro, E., Celada, P., Bortolozzi, A., Pazos, A., Artigas, F. Stragies for producing faster acting antidepressants: Drug discovery Today 10: 578-585, 2005. https://doi.org/10.1016/S1359-6446(05)03398-2
  8. Hong, Y.Y., Moon, I.S., Kim, D.I., Lee, T.K. A study on melatonin, serotonin secretion change and behavior in the rats treated with Yiseontang, Gammakdaejotang, Sanjointang, and Sanjogammaktang. The journal of oriental gynecology 12: 209-230, 1999.
  9. Jeong, H.W., Min, B.I., Rho, Y.H. Experimental effects of Gammakdaejo-tang and it's constituent herbs on the regional cerebral blood flow and cardiacvascular system. Korean journal of medical physiology & pathology. 15: 590-594, 2001.
  10. Park, H.J., Shim, H.S., Kim, H., Kim, K.S., Lee, H., Hahm, D.H., Shim, I. Effects of glycyrrhizae radix on repeated restraint stress-induced neurochemical and behavioral responses: Korean J Physiol Pharmacol 14: 371-376, 2010. https://doi.org/10.4196/kjpp.2010.14.6.371
  11. Paxinos G and Watson C. The rat brain in sterotazic coordinates, 2nd ed. New York: Academic Press, 1986.
  12. Mendonca Netto S.E., Guimaraes, F.S. Intra-hippocampal adminstration of cycloheximide attenuates the restraint-induced exploratory deficit of an elevated plus maze: Behav Brain Res 91: 207-211, 1998. https://doi.org/10.1016/S0166-4328(97)00129-0
  13. Kim, S.C., Byun, S.H., Yang, C.H., Kim, C.Y., Kim, J.W., Kim, S.G. Cytoprotective effects of Glycyrrhizae radix extract and its active component liquiritigenin against cadmium-induced toxicity (effects on bad translocation and PARP cleavage. Toxicology, 197: 239-251, 2004. https://doi.org/10.1016/j.tox.2004.01.010
  14. Kee, C.H. The pharmacology of Chinese herbs, (2nd edn). Boca Ranton: CRC press, 1999.
  15. Dhingra D and Sharma A. Evaluation of antidepressant-like activity of glycyrrhizin in mice, Indian J Pharmacol, 37: 390-394, 2005. https://doi.org/10.4103/0253-7613.19077
  16. Zhao, Z., Wang, W., Guo, H., Zhou, D. Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats. Behav Brain Res, 194: 108-113, 2008. https://doi.org/10.1016/j.bbr.2008.06.030
  17. Lino, O.C., Guimaraes, F.S. C-jun mRNA expression in the hippocampal formation induced by restraint stress: Brain Res 753: 202-208, 1997. https://doi.org/10.1016/S0006-8993(96)01490-4
  18. Titze, A.R., Lino, O.C. Midazolam and the N-methyl-D-aspartate(NMDA) receptor antagonist 2-amino-7-phosphono-heptanoic acid(AP-7) attenuate stress-induced expression of c-fos mRNA in the dentate gyrus: Cell Mol Neurobiol 14: 373-380, 1994. https://doi.org/10.1007/BF02088717
  19. Adams, R.A., Burton, P., Shallow, T. Unilateral block of NMDA receptors in the amygdala prevents predator stress-induced lasting increases in anxiety-like behavior and unconditioned startle effective hemisphere depends on the behavior: Physiol Behav 45: 739-751, 1999.
  20. Guimaraes, C.M., Pinge, M.C., Yamamura, Y., Mello, L.E. Effects of acupuncture on behavioral, cardiovascular and hormonal responses in restraint-stressed Wistar rats: Braz J Med Biol Res 30: 1445-1450, 1997.
  21. Kazushige, M., Mitsutoshi, Y. Effect of chronic stress on cholinergic transmission in rat hippocampus: Brain res 915: 108-111, 2001. https://doi.org/10.1016/S0006-8993(01)02834-7
  22. Safer, D.J., Allen, R.P. The central effects of scopolamine in man: Biol Psychiatry 3: 347-355, 1989.
  23. Izquierdo, I., Izquierdo, L.A., Barros, D.M. Differential involvement of cortical receptor mechanisms in working, short-term and long-term memory: Behav Pharmacol 9: 421-427, 1998. https://doi.org/10.1097/00008877-199809000-00005
  24. Mizoguchi, K., Yuzurihara, M., Ishige, A., Tabira, T. Chronic stress impairs rotarod performance in rats: implicatins for depressive state: Pharmacol Biochem Behav 71: 79-84, 2002. https://doi.org/10.1016/S0091-3057(01)00636-0
  25. Murai, S., Saito, H., Masuda, Y. AF64A disrupts retrieval processes in long-term memory of mice: Neuroreport 6: 349-352, 1995.
  26. Pope, C.N., Ho, B.T., Wright, A.A. Neurochemical and behavioral effects of N-ethyl-acetylcholine aziridinium chloride in mice: Pharmacol Biochem Behav, 26: 365-371, 1987. https://doi.org/10.1016/0091-3057(87)90131-6
  27. Dong, X.P., Xu, T.L. Radix paeoniae rubra suppression of sodium current in acutely dissociated rat hippocampal CA1 neurons: Brain Research 940: 1-9, 2002. https://doi.org/10.1016/S0006-8993(02)02555-6