Journal of the Korean Academy of Child and Adolescent Psychiatry

대한소아청소년정신의학회 (Korean Academy of Child and Adolescent Psychiatry)
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자폐스펙트럼장애에서 나타나는 퇴행의 임상적인 특징

Clinical Characteristics of Developmental Regression in Autism Spectrum Disorders

  • 김지순 (서울대학교병원 신경정신과) ;
  • 유희정 (분당서울대학교병원 신경정신과) ;
  • 조인희 (가천의과학대학교 길병원 정신과) ;
  • 박태원 (충북대학교병원 정신과) ;
  • 손정우 (전북대학교병원 정신과) ;
  • 정운선 (경북대학교병원 정신과) ;
  • 신민섭 (서울대학교병원 신경정신과) ;
  • 김붕년 (서울대학교병원 신경정신과) ;
  • 김재원 (서울대학교병원 신경정신과) ;
  • 양영희 (서울대학교병원 신경정신과) ;
  • 강제욱 (인제대학교병원 신경정신과) ;
  • 송숙형 (서울대학교병원 신경정신과) ;
  • 조수철 (서울대학교병원 신경정신과)
  • Kim, Ji-Soon (Department of Neuropsychiatry, Seoul National University Hospital) ;
  • Yoo, Hee-Jeong (Department of Neuropsychiatry, Seoul National University Bungdang Hospital) ;
  • Cho, In-Hee (Department of Psychiatry, Gachon University Gill Hospital, Gachon University of Medicine and Science) ;
  • Park, Tae-Won (Department of Psychiatry, Chungbuk National University Hospital) ;
  • Son, Jung-Woo (Department of Psychiatry, Chonbuk National University Hospital) ;
  • Chung, Un-Sun (Department of Psychiatry, Kyungpook National University) ;
  • Shin, Min-Sup (Department of Neuropsychiatry, Seoul National University Hospital) ;
  • Kim, Bung-Nyun (Department of Neuropsychiatry, Seoul National University Hospital) ;
  • Kim, Jae-Won (Department of Neuropsychiatry, Seoul National University Hospital) ;
  • Yang, Young-Hui (Department of Neuropsychiatry, Seoul National University Hospital) ;
  • Kang, Je-Wook (Department of Neuropsychiatry, Inje University Hospital) ;
  • Song, Sook-Hyung (Department of Neuropsychiatry, Seoul National University Hospital) ;
  • Cho, Soo-Churl (Department of Neuropsychiatry, Seoul National University Hospital)
  • 투고 : 2011.06.01
  • 심사 : 2011.07.27
  • 발행 : 2011.09.30
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초록

Pbjective : A significant proportion of children with autism spectrum disorders (ASD) have regression characterized by loss of previously acquired skills. The purpose of this study was to compare demographic, clinical characteristics and autism-related symptomatology of the children who have regression with children who don't have regression. Methods : The subjects with ASD and their unaffected siblings (SIB) were recruited from the Korean Autism Genetic Study Consortium. Typically developing children (TC) were volunteered from community. The subjects were administered the Korean version of Autism Diagnostic Interview-Revised (K-ADI-R) and the Korean version of Autism Diagnostic Observation Schedule (K-ADOS) to diagnose or exclude ASD. Regression was defined on the basis of K-ADI-R data. The Korean version of Vineland Adaptive Behavior Scale (K-VABS), Aberrant Behavior Checklist (K-ABC) and Social Responsiveness Scale (K-SRS) were obtained from their parents. Results : Regression occurred in 8.33% (n=14) of children with ASD (n=168). Any SIB (n=166) and TC (n=53) did not experience regression. Regression was associated with lower IQ and lower score of K-VABS. There was no difference in autism symptom severity and K-ABC, K-SRS scores, between children with ASD who experienced regression and who did not. Conclusion : Regression seems to be a distinctive feature of ASD. Regression is associated with cognitive and more general functions, rather than symptoms specific to autism.

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참고문헌

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피인용 문헌

  1. Comparison of the Autism Diagnostic Observation Schedule and Childhood Autism Rating Scale in the Diagnosis of Autism Spectrum Disorder: A Preliminary Study vol.29, pp.4, 2018, https://doi.org/10.5765/jkacap.180015
  2. Changes in Children with Autism Spectrum Disorder after Theraplay Application vol.32, pp.3, 2011, https://doi.org/10.5765/jkacap.210001