Asian-Australasian Journal of Animal Sciences

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of the Combination of Glucose, Chromium Picolinate, and Vitamin C on Lipid Metabolism in Steers

  • Lee, Hong-Gu (Department of Animal Science, Pusan National University) ;
  • Yin, Jin-Long (Department of Animal Science and Technology and Research Institute for Agriculture and Life Sciences, Seoul National University) ;
  • Xu, Cheng-Xiong (Department of Molecular Oncology, H Lee Moffitt Cancer Center) ;
  • Hong, Zhong-Shan (Department of Animal Science and Technology, Tianjin Agricultural University) ;
  • Lee, Zhe-Hu (Department of Animal Science and Technology and Research Institute for Agriculture and Life Sciences, Seoul National University) ;
  • Jin, Yong-Cheng (Department of Animal Science, Pusan National University) ;
  • Choi, Chang-Weon (Department of Animal Resources, Daegu University) ;
  • Lee, Do-Hyeung (GRRC, Hankyong University) ;
  • Kim, Kyoung-Hoon (National Livestock Research Institute, RDA) ;
  • Choi, Yun-Jaie (Department of Animal Science and Technology and Research Institute for Agriculture and Life Sciences, Seoul National University)
  • Received : 2011.03.21
  • Accepted : 2011.06.03
  • Published : 2011.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

This study was conducted to examine the effects of glucose, chromium picolinate (CrP), and vitamin C (Vit C) on lipid metabolism in Korean native steers fitted with indwelling catheters. A total of 12 Korean native steers were randomly allocated to the following treatments: 1) normal control diet, 2) same as 1) +250 g of glucose by intravenous (IV) infusion, 3) same as 2)+13.5 g CrP administered orally, and 4) same as 3)+2.52 g Vit C by IV infusion. Glucose, Vit C, and CrP treatments were administered for five days. At days 1 and 3, serum insulin was higher in treated animals than in those fed the control diet (p<0.05). Serum non-esterified fatty acid (NEFA) concentration in the steers on treatment 2), control+13.5 g CrP, was lower than those on other treatments at 90 min post-infusion on days 1 and 3 (p<0.05). The expression of peroxisome proliferator-activated receptor-${\gamma}$ (PPAR${\gamma}$)2, stearoyl-CoA desaturase-1 (SCD), fatty acid synthase (FAS), and glucose transporter type 4 (Glut 4) in the longissimus muscle of steers on treatment 2 was higher than those on other treatments. In conclusion, the results suggest that CrP is associated with the regulation of gene expression involved in adipogenesis.

Keywords

References

  1. Amri, E. Z., F. Bonino, G. Ailhaud, N. A. Abumrad and P. A. Grimaldi. 1995. Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes: homology to peroxisome proliferator-activated receptors. J. Biol. Chem. 270:2367-2371. https://doi.org/10.1074/jbc.270.5.2367
  2. Anderson, R. A. 1998. Chromium, glucose intolerance and diabetes. J. Am. Coll. Nutr. 17:548-555. https://doi.org/10.1080/07315724.1998.10718802
  3. Bastie, C., D. Holst, D. Gaillard, C. Jehl-Pietri adn P. A. Grimaldi. 1999. Expression of peroxisome proliferator-activated receptor PPARdelta promotes induction of PPARgamma and adipocyte differentiation in 3T3C2 fibroblasts. J. Biol. Chem. 274: 21920-21925. https://doi.org/10.1074/jbc.274.31.21920
  4. Bell-Parikh, L.C., T. Ide, J. A. Lawson, P. McNamara, M. Reilly and G. A. FitzGerald. 2003. Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma. J. Clin. Invest. 112945-955.
  5. Berger, J. and D. E. Moller. 2002. The mechanism of action of PPARs Annu. Rev. Med. 53:409-435. https://doi.org/10.1146/annurev.med.53.082901.104018
  6. Bernlohr, D. A., M. A. Bolanowski, T. J. J. Kelly and M. D. Lane. 1985 Evidence for an increase in transcription of specific mRNAs during differentiation of 3T3-L1 preadipocytes. J. Biol. Chem. 260:5563-5567.
  7. Cheah, K. S., A. M. Cheah and A. Just. 1997. A simple and rapid biopsy technique for obtaining fat and muscle samples from live animals for predicting meat quality. Dan. Veterinaertidsskr. 80:775-777.
  8. Cianzio, D. S., D. G. Topel, G. B. Whitehurst, D. C. Beitz and H. L. Self. 1985. Adipose tissue growth and cellularity: changes in bovine adipocyte size and number. J. Anim Sci. 60:970-976.
  9. Desvergne, B. and W. Wahli. 1999b. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr. Rev. 20:649-688. https://doi.org/10.1210/er.20.5.649
  10. Ntambi, J. M. 1999. Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol. J. Lipid Res. 40:1549-1588.
  11. Hood, R, L. and C. E. Allen. 1973. Cellularity of bovine adipose tissue. J. Lipid Res. 14:605-610.
  12. Kliewer, S. A., S. S. Sundseth, S. A. Jones, P. J. Brown, G. B. Wisely, C. S. Koble, P. Devchand, W. Wahli, T. M. Willson, J. M. Lenhard and J. M. Lehmann. 1997. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors ${\alpha}\;and\;{\gamma}$. Proc. Natl. Acad. Sci. USA. 94:4318-4323. https://doi.org/10.1073/pnas.94.9.4318
  13. MacDougald, O. A. and M. D. Lane. 1995. Transcriptional regulation of gene expression during adipocyte differentiation. Annu. Rev. Biochem. 64:345-373. https://doi.org/10.1146/annurev.bi.64.070195.002021
  14. McDowell, L. R. 1989. Vitamins in animal nutrition. Academic press, New York.
  15. McIntyre, T. M., A. V. Pontsler, A. R. Silva, A. St Hilaire, Y. Xu, J. C. Hinshaw, G. A. Zimmerman, K. Hama, J. Aoki, H. Arai and G. D. Prestwich. 2003. Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist. Proc. Natl. Acad. Sci. USA 100:131-136. https://doi.org/10.1073/pnas.0135855100
  16. Mertz, W. 1993. Chromium in human nutrition: a review. J. Nutr. 123:626-633.
  17. Mooradian, A. D. and J. E. Morley. 1997. Micronutrient status in diabetes mellitus. Am. J. Clin. Nutr. 45:877-895.
  18. Mowat, D. N. 1997. Organic Chromium in Animal Nutrition. Chromium Books, Guelph, ON, Canada.
  19. Nagy, L., P. Tontonoz, J. G. Alvarez, H. Chen and R. M. Evans. 1998. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell. 93:229-240. https://doi.org/10.1016/S0092-8674(00)81574-3
  20. Ohashi, H., H. Takizawa and M. Matsui. 2000. Effect of vitamin C on the quality of Wagyu beef. Research bulletin of aichi agriculture research center. 32:207-214. (In Japanese)
  21. Pethick, D. W. 1984. Energy metabolism of skeletal muscle, in: Ruminant Physiology (Ed. J. M. Gawthorne, S. K. Baker, J. B. Mac, D. B. Kintosh Purser). Concepts and Consequences. Symposium held at University of Western Australia, 7-10 May 1984, Nedlands, Australia, 1984. pp. 277-287.
  22. Poirier, H., I. Niot, M. C. Monnot, O. Braissant, C. Meunier-Durmort, P. Costet, T. Pineau, W. Wahli, T. M. Willson and P. Besnard. 2001. Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine. Biochem. J. 355:481-488. https://doi.org/10.1042/0264-6021:3550481
  23. Parsey, R. V. and D. R. Matteson. 1993. Ascorbic acid modulation of calcium channels in pancreatic ${\beta}$ cells. J. Gen. Physiol. 102(3):503-523. https://doi.org/10.1085/jgp.102.3.503
  24. Sahin, K., N. Sahin and O. Kucuk. 2003. Effects of chromium, and ascorbic acid supplementation on growth, carcass traits, serum metabolites, and antioxidant status of broiler chickens reared at a high ambient temperature $(32^{\circ}C)$. Nutr. Res. 23:225-238. https://doi.org/10.1016/S0271-5317(02)00513-4
  25. Smith, S. B. and J. D. Crouse. 1984. Relative contributions of acetate, lactate and glucose to lipogenesis in bovine intramuscular and subcutaneous adipose tissue. J. Nutr. 114:798-800.
  26. Steel, R. G. D. and J. H. Torrie. 1980. Principles and Procedures of Statistics. McGraw-Hill Book Co., NY, USA.
  27. Straus, D. S., G. Pascual, M. Li, J. S. Welch, M. Ricote, C. H. Hsiang, L. L. Sengchanthalangsy, G. Ghosh and C. K. Glass. 2000. 15-deoxydelta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway. Proc. Natl. Acad. Sci. USA 97:4844-4849. https://doi.org/10.1073/pnas.97.9.4844
  28. Stryer, Lupert. 1995. Biochemistry. New York: W. H. Freeman and Co., 1995. 773
  29. Tontonoz, P., E. Hu, R. A. Graves, A. I. Budavari and B. M. Spiegelman. 1994. PPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 8:1224-1234. https://doi.org/10.1101/gad.8.10.1224
  30. Toriisin, I., Matsuda, K et al. 1995. Society of beef cattle science. 59:25-29.
  31. Wells, W. W., C. Z. Dou, L. N. Dybas, C. H. Jung, H. L. Kalbach and D. P. Xu. 1995. Ascorbic acid is essential for the release of insulin from scorbutic guinea pig pancreatic islets. Proc. Natl. Acad. Sci. USA. 92(25):11869-11873. https://doi.org/10.1073/pnas.92.25.11869

Cited by

  1. Effects of Chromium and Carnitine Co-supplementation on Body Weight and Metabolic Profiles in Overweight and Obese Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled vol.193, pp.2, 2011, https://doi.org/10.1007/s12011-019-01720-8