Nutrition Research and Practice

  • 제5권4호
  • /
  • Pages.301-307
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  • 2011
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  • 1976-1457(pISSN)
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  • 2005-6168(eISSN)
한국영양학회 (The Korean Nutrition Society)
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Hypolipidemic and hypoglycemic effects of Orostachys japonicus A. Berger extracts in streptozotocin-induced diabetic rats

  • Lee, Soo-Jung (Department of Food and Nutrition, Institute of Agriculture and Life Science, Gyeongsang National University) ;
  • Zhang, Gui Fang (Department of Food and Nutrition, Institute of Agriculture and Life Science, Gyeongsang National University) ;
  • Sung, Nak-Ju (Department of Food and Nutrition, Institute of Agriculture and Life Science, Gyeongsang National University)
  • 투고 : 2011.01.21
  • 심사 : 2011.07.25
  • 발행 : 2011.08.31
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초록

The hypolipidemic and hypoglycemic effects of two dietary dosages (0.1% and 0.5%) of water and 80% ethanol extracts from hot-air dried Orostachys japonicus A. Berger were evaluated in the serum and organ tissues of streptozotocin-induced diabetic rats. The STZ-induced diabetic groups supplemented with the O. japonicus extracts showed significantly higher body weight compared to a diabetic control group at the end of experiment. The extracts exhibited substantial hypoglycemic effects by significant reductions of fasting blood glucose levels at all time points tested compared to the initial stage before treatment of the extracts. Declines of serum and hepatic triglyceride levels were greater than declines of total cholesterol in the groups treated with the 0.5% O. japonicus extract (DBW2 and DBE2) when compared to the DBC group. Hepatic glycogen content was higher in the groups treated with O. japonicus extract, while lipid peroxide content was decreased in these treated groups compared to the DBC group. Hepatic antioxidant activity was significantly increased in the groups supplemented with the O. japonicus ethanol extract The hypolipidemic and hypoglycemic effects of the O. japonicus ethanol extract were significantly greater than the effects of the water extract. Based on this study, it seems that O. japonicus ethanol extract, due to its higher phenolic and flavonoid components than the water extract, may control blood glucose and alleviate hyperlipidemia in diabetes.

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참고문헌

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피인용 문헌

  1. Effect of a Combined Extract of Orostachys japonicus with Medicinal Plants on the Lipid Composition of the Liver and Kidney from Streptozotocin-induced Diabetic Rats vol.41, pp.4, 2012, https://doi.org/10.3746/jkfn.2012.41.4.510
  2. Hypoglycemic and Hypolipidemic Effects of Orostachys japonicus with Medicinal Herbs in Streptozotocin-Induced Diabetic Rats vol.42, pp.4, 2013, https://doi.org/10.3746/jkfn.2013.42.4.587
  3. Effect of Black Garlic and Gaeddongssuk (Artemisia annua L.) Extracts on the Lipid Profile and Hepatic Antioxidant Enzyme Activities of Exercised Rats vol.42, pp.6, 2013, https://doi.org/10.3746/jkfn.2013.42.6.869
  4. in mice vol.52, pp.10, 2014, https://doi.org/10.3109/13880209.2014.892142
  5. A. Berger (Crassulaceae) on hepatic stellate cells and thioacetamide-induced fibrosis in rats vol.11, pp.6, 2017, https://doi.org/10.4162/nrp.2017.11.6.470
  6. Herbal Remedies: A Boon for Diabetic Neuropathy pp.1939-022X, 2018, https://doi.org/10.1080/19390211.2018.1441203
  7. A. Berger Extracts Induce Immunity-Enhancing Effects on Cyclophosphamide-Treated Immunosuppressed Rats vol.2019, pp.2314-6141, 2019, https://doi.org/10.1155/2019/9461960
  8. Orostachys japonicus A. Berger (Crassulaceae) Exerts Antidiabetic Activity by Improving Glucose and Lipid Levels in Type 2 Diabetic Mice vol.22, pp.8, 2011, https://doi.org/10.1089/jmf.2018.4391
  9. 인체 흑색종 세포에 대한 와송 추출물의 세포주기 억제를 통한 항암효과와 기전 연구 vol.32, pp.4, 2011, https://doi.org/10.6114/jkood.2019.32.4.001
  10. Efficacy of a Novel Herbal Formulation (F2) on the Management of Obesity: In Vitro and In Vivo Study vol.2021, pp.None, 2011, https://doi.org/10.1155/2021/8854915
  11. Exercise and Nutraceuticals: Eminent Approach for Diabetic Neuropathy vol.14, pp.None, 2021, https://doi.org/10.2174/1874467214666210629123010
  12. Ethanol Extract of Orostachys japonicus A. Berger (Crassulaceae) Protects Against Type 2 Diabetes by Reducing Insulin Resistance and Hepatic Inflammation in Mice vol.24, pp.5, 2011, https://doi.org/10.1089/jmf.2020.4790
  13. Evaluation of Anti-Obesity Activity of an Herbal Formulation (F2) in DIO Mice Model and Validation of UPLC-DAD Method for Quality Control vol.11, pp.16, 2021, https://doi.org/10.3390/app11167404