DOI QR코드

DOI QR Code

Health Risks Assessment in Children for Phthalate Exposure Associated with Childcare Facilities and Indoor Playgrounds

  • Kim, Ho-Hyun (Institute for Environmental Research, Yonsei University College of Medicine) ;
  • Yang, Ji-Yeon (Institute for Environmental Research, Yonsei University College of Medicine) ;
  • Kim, Sun-Duk (Institute for Environmental Research, Yonsei University College of Medicine) ;
  • Yang, Su-Hee (Institute for Environmental Research, Yonsei University College of Medicine) ;
  • Lee, Chung-Soo (Institute for Environmental Research, Yonsei University College of Medicine) ;
  • Shin, Dong-Chun (Department of Preventive Medicine, Yonsei University College of Medicine) ;
  • Lim, Young-Wook (Institute for Environmental Research, Yonsei University College of Medicine)
  • Received : 2011.01.14
  • Accepted : 2011.04.15
  • Published : 2011.01.01

Abstract

Objectives: This study assessed the health risks for children exposed to phthalate through several pathways including house dust, surface wipes and hand wipes in child facilities and indoor playgrounds. Methods: The indoor samples were collected from various children's facilities (40 playrooms, 42 daycare centers, 44 kindergartens, and 42 indoor-playgrounds) in both summer (Jul-Sep, 2007) and winter (Jan-Feb, 2008). Hazard index (HI) was estimated for the non-carcinogens and the examined phthalates were diethylhexyl phthalate (DEHP), diethyl phthalate (DEP), dibutyl-n-butyl phthalate (DnBP), and butylbenzyl phthalate (BBzP). The present study examined these four kinds of samples, i.e., indoor dust, surface wipes of product and hand wipes. Results: Among the phthalates, the detection rates of DEHP were 98% in dust samples, 100% in surface wipe samples, and 95% in hand wipe samples. In this study, phthalate levels obtained from floor dust, product surface and children's hand wipe samples were similar to or slightly less compared to previous studies. The $50^{th}$ and $95^{th}$ percentile value of child-sensitive materials did not exceed 1 (HI) for all subjects in all facilities. Conclusions: For DEHP, DnBP and BBzP their detection rates through multi-routes were high and their risk based on health risk assessment was also observed to be acceptable. This study suggested that ingestion and dermal exposure could be the most important pathway of phthalates besides digestion through food.

Keywords

References

  1. Ministry of Environment. A study about safety to use of phthalate. Gwacheon: Ministry of Environment; 2006. (Korean)
  2. Becker K, Seiwert M, Angerer J, Heger W, Koch HM, Nagorka R, et al. DEHP metabolites in urine of children and DEHP in house dust. Int J Hyg Environ Health 2004; 207(5): 409-417. https://doi.org/10.1078/1438-4639-00309
  3. Silva MJ, Samandar E, Preau JL Jr, Reidy JA, Needham LL, Calafat AM. Quantification of 22 phthalate metabolites in human urine. J Chromatogr B Analyt Technol Biomed Life Sci 2007; 860(1): 106-112. https://doi.org/10.1016/j.jchromb.2007.10.023
  4. Latini G. Monitoring phthalate exposure in humans. Clin Chim Acta 2005; 361(1-2): 20-29. https://doi.org/10.1016/j.cccn.2005.05.003
  5. Wittassek M, Wiesmuller GA, Koch HM, Eckard R, Dobler L, Muller J, et al. Internal phthalate exposure over the last two decades-a retrospective human biomonitoring study. Int J Hyg Environ Health 2007; 210(3-4): 319-333. https://doi.org/10.1016/j.ijheh.2007.01.037
  6. Jaakkola JJ, Oie L, Nafstad P, Botten G, Samuelsen SO, Magnus P. Interior surface materials in the home and the development of bronchial obstruction in young children in Oslo, Norway. Am J Public Health 1999; 89(2): 188-192. https://doi.org/10.2105/AJPH.89.2.188
  7. Bornehag CG, Sundell J, Weschler CJ, Sigsgaard T, Lundgren B, Hasselgren M, et al. The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study. Environ Health Perspect 2004; 112(14): 1393-1397. https://doi.org/10.1289/ehp.7187
  8. Kim HH, Lim YW, Yang JY, Shin DC. Occurrence of phthalates in indoor dust from children's facilities and apartments in Seoul. J Korean Soc Atoms Environ 2009; 25(5); 382-391. https://doi.org/10.5572/KOSAE.2009.25.5.382
  9. Yang JY, Kim HH, Yang SH, Kim SD, Jeon JM, Shin DC, et al. Health risk assessment of aldehydes and VOCs in the activities space of young children; focused on child-care facilities and indoor playgrounds. J Environ Toxicol 2010; 25(1); 57-68. (Korean)
  10. Stapleton HM, Dodder NG, Offenberg JH, Schantz MM, Wise SA. Polybrominated diphenyl ethers in house dust and clothes dryer lint. Environ Sci Technol 2005; 39(4): 925-931. https://doi.org/10.1021/es0486824
  11. Webster T, Vieira V, Schecter A. Estimating human exposure to PBDE-47 via air, food and dust using Monte Carlo methods. Organohalogen Compd 2005; 67: 505-508.
  12. Cohen Hubal EA, Sheldon LS, Burke JM, McCurdy TR, Berry MR, Rigas ML, et al. Children's exposure assessment: a review of factors influencing children's exposure and the data available to characterize and assess that exposure. Environ Health Perspect 2000; 108(6): 475-486. https://doi.org/10.1289/ehp.00108475
  13. Freeman NC, Sheldon L, Jimenez M, Melnyk L, Pellizzari E, Berry M. Contribution of children's activities to lead contamination of food. J Expo Anal Environ Epidemiol 2001; 11(5): 407-413. https://doi.org/10.1038/sj.jea.7500183
  14. Freeman NC, Jimenez M, Reed KJ, Gurunathan S, Edwards RD, Roy A, et al. Quantitative analysis of children's micro-activity patterns: The Minnesota Children's Pesticide Exposure Study. J Expo Anal Environ Epidemiol 2001; 11(6): 501-509. https://doi.org/10.1038/sj.jea.7500193
  15. Tulve NS, Suggs JC, McCurdy T, Cohen Hubal EA, Moya J. Frequency of mouthing behavior in young children. J Expo Anal Environ Epidemiol 2002; 12(4): 259-264. https://doi.org/10.1038/sj.jea.7500225
  16. US Environment Protection Agency. Child-specific exposure factors handbook. Final report, 2008.[Cited 2008 Oct 31]. Available from:http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=199243.
  17. Carpenter CP, Weil CS, Smith HF Jr. Chronic oral toxicity of di-(2-ethylhexyl)phthalate for rats, guinea pigs and dogs. AMA Arch Ind Hyg Occup Med 1953; 8(3): 219-226.
  18. Brown D, Butterworth KR, Gaunt IF, Grasso P, Gangolli SD. Short-term oral toxicity study of diethyl phthalate in the rat. Food Cosmet Toxicol 1978; 16(5): 415-422. https://doi.org/10.1016/S0015-6264(78)80258-2
  19. Smith CC. Toxicity of butyl stearate, dibutyl sebacate, dibutyl phthalate, and methoxyethyl oleate. AMA Arch Ind Hyg Occup Med 1953; 7(4): 310-318.
  20. NTP(National Toxicolgy Program). Twenty-six week subchronic study and modified mating trial in F344 rats. Butyl benzyl phthalate. Final report, 1985. [Cited 2008 Oct 31]. Available from:http://www.epa.gov/iris/subst/0293.htm.
  21. Bornehag CG, Lundgren B, Weschler CJ, Sigagaard T, Hagerhed-Engman L, Sundell J. Phthalates in indoor dust and their association with building characteristics. Environ Health Perspect 2005; 113(10): 1399-1404. https://doi.org/10.1289/ehp.7809
  22. Clausen PA, Lindeberg Bille RL, Nilsson T, Hansen V, Svensmark B, Bowadt S. Simultaneous extraction of di(2-ethylhexyl) phthalate and nonionic surfactants from house dust, Concentrations in floor dust from 15 Danish schools. J Chromatogr A 2003; 986(2): 179-190. https://doi.org/10.1016/S0021-9673(02)02007-1
  23. Inoue K, Kawaguchi M, Yamanaka R, Higuchi T, Ito R, Saito K, et al. Evaluation and analysis of exposure levels of di(2-ethylhexyl) phthalate from blood bags. Clin Chim Acta 2005; 358(1-2): 159-166. https://doi.org/10.1016/j.cccn.2005.02.019
  24. Uhde E, Bednarek M, Fuhrmann F, Salthammer T. Phthalic esters in the indoor environment-test chamber studies on PVC-coated wallcoverings. Indoor Air 2001; 11(3): 150-155. https://doi.org/10.1034/j.1600-0668.2001.011003150.x
  25. CERHR (NTP Center for the Evaluation of Risks to Human Reproduction). NTP-CERHR expert panel report on Di(2-ethylhexyl) phthalate. NC, USA: Research Triangle Park; 2000.
  26. Koch HM, Drexler H, Angerer J. Internal exposure of nursery-school children and their parents and teachers to di(2-ethylhexyl)phthalate (DEHP). Int J Hyg Environ Health 2004; 207(1): 15-22. https://doi.org/10.1078/1438-4639-00270
  27. Koch HM, Bolt HM, Preuss R, Angerer J. New metabolites of di(2-ethylhexyl)phthalate (DEHP) in human urine and serum after single oral doses of deuterium-labelled DEHP. Arch Toxicol 2005; 79(7): 367-376. https://doi.org/10.1007/s00204-004-0642-4
  28. Meek M, Chan PKL. Bis(2-ethylhexyl)phthalate: evaluation of risks to health from environmental exposure in Canada. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 1994; 12(2): 179-194. https://doi.org/10.1080/10590509409373439
  29. Fromme H, Lahrz T, Piloty M, Gebhart H, Oddoy A, Ruden H. Occurrence of phthalates and musk fragrances in indoor air and dust from apartments and kindergartens in Berlin (Germany). Indoor Air 2004; 14(3): 188-195. https://doi.org/10.1111/j.1600-0668.2004.00223.x
  30. Jang JY, Jo SN, Kim SY, Kim SJ, Cheong HK. Korean exposure factors handbook (KEFH). Gwacheon: Ministry of Environment; 2007.
  31. US EPA (Environmental Protection Agency). Child specific exposure factors handbook (CEFH). Washington DC; US EPA; 2002.
  32. Zartarian VG, Xue J, Ozkaynak HA, Dang W, Glen G, et al. A probabilistic exposure assessment for children who contact CCA-treated playsets and decks using the stochastic human exposure and dose simulation model for the wood preservative scenario (SHEDS-Wood). Final report. EPA/600/X-05/009. [cited 2008 Oct 11] Available from:http://www.epa.gov/ heasd/sheds/cca_ treated.htm.

Cited by

  1. Health Risk Assessment for Artificial Turf Playgrounds in School Athletic Facilities: Multi-route Exposure Estimation for Use Patterns vol.6, pp.3, 2011, https://doi.org/10.5572/ajae.2012.6.3.206
  2. A critical assessment of the endocrine susceptibility of the human testis to phthalates from fetal life to adulthood vol.20, pp.2, 2011, https://doi.org/10.1093/humupd/dmt050
  3. Korean Environmental Health Survey in Children and Adolescents (KorEHS-C): Survey design and pilot study results on selected exposure biomarkers vol.217, pp.2, 2011, https://doi.org/10.1016/j.ijheh.2013.06.001
  4. Phthalate Exposure and Risk Assessment in California Child Care Facilities vol.48, pp.13, 2011, https://doi.org/10.1021/es501189t
  5. Measurement of Phthalates in Skin Wipes: Estimating Exposure from Dermal Absorption vol.48, pp.13, 2011, https://doi.org/10.1021/es501700u
  6. Transdermal Uptake of Diethyl Phthalate and Di( n -butyl) Phthalate Directly from Air: Experimental Verification vol.123, pp.10, 2011, https://doi.org/10.1289/ehp.1409151
  7. Endocrine disruptor phthalates in bottled water: daily exposure and health risk assessment in pregnant and lactating women vol.188, pp.9, 2011, https://doi.org/10.1007/s10661-016-5502-1
  8. Experimental estimation of migration and transfer of organic substances from consumer articles to cotton wipes: Evaluation of underlying mechanisms vol.26, pp.1, 2011, https://doi.org/10.1038/jes.2015.35
  9. Impact of Clothing on Dermal Exposure to Phthalates: Observations and Insights from Sampling Both Skin and Clothing vol.50, pp.8, 2016, https://doi.org/10.1021/acs.est.6b00113
  10. Phthalate Esters on Hands of Office Workers: Estimating the Influence of Touching Surfaces vol.4, pp.1, 2011, https://doi.org/10.1021/acs.estlett.6b00458
  11. Removal of Diethylhexyl Phthalate from Hands by Handwashing: Evidence from Experimental N-of-1 and Crossover Designs vol.7, pp.None, 2011, https://doi.org/10.1038/s41598-017-00581-2
  12. Exposure to phthalates and bisphenol A are associated with atopic dermatitis symptoms in children: a time-series analysis vol.16, pp.None, 2017, https://doi.org/10.1186/s12940-017-0225-5
  13. Analysis and Assessment of Exposure to Selected Phthalates Found in Children’s Toys in Christchurch, New Zealand vol.15, pp.2, 2011, https://doi.org/10.3390/ijerph15020200
  14. Skin transferability of phthalic acid ester plasticizers and other plasticizers using model polyvinyl chloride sheets vol.55, pp.10, 2020, https://doi.org/10.1080/10934529.2020.1795503
  15. The High Complexity of Plastic Additives in Hand Wipes vol.8, pp.8, 2011, https://doi.org/10.1021/acs.estlett.1c00381
  16. Analysis and health risk assessment of phthalate esters (PAEs) in indoor dust of preschool and elementary school centers in city of Tehran, Iran vol.28, pp.43, 2011, https://doi.org/10.1007/s11356-021-14845-y
  17. Phthalates in skin wipes: Distribution, sources, and exposure via dermal absorption vol.204, pp.no.pb, 2011, https://doi.org/10.1016/j.envres.2021.112041