Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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A Study of the Relationships between the Ratio of $2^{nd}$ to $4^{th}$ Digit Length and Cerebral Laterality

제2수지-제4수지 길이 비율과 대뇌 편측화 관계 연구

  • Received : 2010.09.29
  • Accepted : 2010.11.04
  • Published : 2011.02.28
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Abstract

Objectives : Cerebral laterality is thought to be an important marker for neurodevelopment. Prenatal testosterone could influence both cerebral laterality and 2nd to 4th finger length ratio(2D : 4D). EEG coherence and 2D : 4D were examined to investigate the relationship between prenatal testosterone level and cerebral laterality. Methods : EEG was recorded in 24 healthy subjects in the eyes closed resting state. Differences in 2D : 4D finger ratio were used to discriminate "masculine finger type" and "feminine finger type" groups. The 2D : 4D ratio was lower and greater than one for the "masculine finger type" group and "feminine finger type" group, respectively. We used coherence analysis to estimate the cortical functional connectivity. Results : There were statistically meaningful relationships among cerebral functional connectivity, sex and finger ratio. Man and masculine finger type group showed higher intra-hemispheric coherence than those of woman and feminine finger type group. Woman and feminine finger type group showed higher inter-hemispheric coherence than those of man and masculine finger type group. Conclusions : These results imply that prenatal testosterone might act as important determinants of cerebral laterality. Further examination of the relationship between 2D : 4D and EEG coherence in schizophrenia could give some clues for the neurodevelopmental hypothesis of schizophrenia genesis.

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References

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