Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Understanding of Neural Mechanism of Mood Disorders : Focused on Neuroimaging Findings

기분장애 뇌신경기저에 대한 이해 : 뇌영상 연구를 중심으로

  • Kim, Yoo-Ra (Department of Psychiatry, The Catholic University of Korea College of Medicine) ;
  • Lee, Kyoung-Uk (Department of Psychiatry, The Catholic University of Korea College of Medicine)
  • 김유라 (가톨릭대학교 의과대학 정신과학교실) ;
  • 이경욱 (가톨릭대학교 의과대학 정신과학교실)
  • Received : 2011.01.10
  • Accepted : 2011.02.01
  • Published : 2011.02.28
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Abstract

Mood disorder is unlikely to be a disease of a single brain region or a neurotransmitter system. Rather, it is now generally viewed as a multidimensional disorder that affects many neural pathways. Growing neuroimaging evidence suggests the anterior cingulate-pallidostriatal-thalamic-amygdala circuit as a putative cortico-limbic mood regulating circuit that may be dysfunctional in mood disorders. Brain-imaging techniques have shown increased activation of mood-generating limbic areas and decreased activation of cortical areas in major depressive disorder(MDD). Furthermore, the combination of functional abnormalities in limbic subcortical neural regions implicated in emotion processing together with functional abnormalities of prefrontal cortical neural regions probably result in the emotional lability and impaired ability to regulate emotion in bipolar disorder. Here we review the biological correlates of MDD and bipolar disorder as evidenced by neuroimaging paradigms, and interpret these data from the perspective of endophenotype. Despite possible limitations, we believe that the integration of neuroimaging research findings will significantly advance our understanding of affective neuroscience and provide novel insights into mood disorders.

Keywords

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