Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Effects of Smoking Cessation on Plasma Levels of Leptin, Ghrelin, Glucagon-Like Peptide 1, and Nerve Growth Factor

금연이 혈중 Leptin, Ghrelin, Glucagon-Like Peptide 1, Nerve Growth Factor의 농도에 미치는 영향

  • Lee, Hee-Mi (Department of Psychiatry, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Won, Wang-Youn (Department of Psychiatry, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Kim, Dai-Jin (Department of Psychiatry, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea)
  • 이희미 (가톨릭대학교 의과대학 서울성모병원 정신과학교실) ;
  • 원왕연 (가톨릭대학교 의과대학 서울성모병원 정신과학교실) ;
  • 김대진 (가톨릭대학교 의과대학 서울성모병원 정신과학교실)
  • Received : 2010.11.15
  • Accepted : 2010.11.25
  • Published : 2011.05.31
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Abstract

Objectives It is well-known that tobacco smoking is related to various disease entities including chronic obstructive pulmonary disease, inflammation, cardiovascular disease, and neoplasms. The prohibition of smoking is important for the protection of these health problems. Regarding leptin, ghrelin, glucagon-like peptide 1 (GLP-1), and nerve growth factor (NGF) levels, correlations with the smoking are suggested but the reports on the effects after smoking cessation are not sufficient. Method The changes of plasma levels of leptin, ghrelin, GLP-1, and NGF levels were analyzed after quitting smoking in Korean adults. Eleven participants succeeding in quitting smoking among 37 male smokers were included in the final analysis. The plasma levels of NGF, leptin, ghrelin, and GLP-1 were measured before and after 8-weeks period of smoking cessation. Results The plasma level of leptin increased after 4 weeks of smoking cessation. In addition, the plasma level of NGF increased after 8 weeks of smoking cessation (p < 0.05). Conclusion Our results suggested that smoking cessation induces increases in leptin and the NGF level after smoking cessation. Many toxic materials including nicotine in the cigarette may be related to these changes of plasma level of leptin and NGF, playing a key role in neurogenesis and synaptic plasticity.

Keywords

References

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