Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Neurobiology of Addiction Based on Neuroimaging Evidence

중독 정신 병리의 이해 : 뇌영상 연구를 중심으로

  • Min, Jung-Ah (Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine) ;
  • Kim, Dai-Jin (Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine)
  • 민정아 (가톨릭대학교 의과대학 서울성모병원 정신과학교실) ;
  • 김대진 (가톨릭대학교 의과대학 서울성모병원 정신과학교실)
  • Received : 2011.04.07
  • Accepted : 2011.04.27
  • Published : 2011.05.31
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Abstract

Substance addiction is a chronically relapsing disorder that has been characterized by a vicious cycle composed of intoxication, craving/anticipation, withdrawal, and response inhibition/bingeing. Here we summarize the findings from neuroimaging studies in addiction according to these behavioral components and suggest the integrated neurobiological model of drug addiction and related brain correlates. The roles of various prefrontal regions, thalamus, memory circuit, anterior cingulated, and insula were also suggested in addition to those of classical mesolimbic dopaminergic system and its responsivity. Limited studies of behavioral addiction demonstrated a similarity with substance addiction on the neurobiological basis. Based on the current understanding of neurobiology of addiction, further researches on interactions of behavioral components and their brain correlates, behavioral addiction, and therapeutic applications will be desired.

Keywords

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