개에서 흉선종의 영상의학적 진단례

Medical Imaging of Thymoma in a Dog

  • 최호정 (충남대학교 수의과대학) ;
  • 이영원 (충남대학교 수의과대학) ;
  • 김재훈 (제주대학교 수의과대학) ;
  • 신창호 (경상대학교 생명과학연구원) ;
  • 박기태 (경상대학교 생명과학연구원) ;
  • 연성찬 (경상대학교 생명과학연구원) ;
  • 이효종 (경상대학교 생명과학연구원) ;
  • 이희천 (경상대학교 생명과학연구원)
  • Choi, Ho-Jung (College of Veterinary Medicine, Chungnam National University) ;
  • Lee, Young-Won (College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Jae-Hoon (College of Veterinary Medicine, Jeju National University) ;
  • Shin, Chang-Ho (Research Institute of Life Sciences, Gyeongsang National University) ;
  • Park, Ki-Tae (Research Institute of Life Sciences, Gyeongsang National University) ;
  • Yeon, Seong-Chan (Research Institute of Life Sciences, Gyeongsang National University) ;
  • Lee, Hyo-Jong (Research Institute of Life Sciences, Gyeongsang National University) ;
  • Lee, Hee-Chun (Research Institute of Life Sciences, Gyeongsang National University)
  • 심사 : 2011.04.04
  • 발행 : 2011.08.30

초록

A 15-year-old, castrated male shih-tzu dog was referred to Veterinary Medical Teaching Hospital of Gyeongsang National University due to dyspnea, anorexia, depression of 1 week's duration. On thoracic radiography, triangular shaped soft tissue opacity mass presented in the left cranial lung lobe region. On computed tomography, there was a $3.8{\times}2.5$ cm mass in the left thoracic cavity, which was lobulated and adhered to ventral pleural surface. Histopathologically, the neoplastic cell population consisted of a lot of lymphocytes and a few of Hassal's corpuscles. The immunohistochemistry, lymphocytes were diffusely positive for CD3 and focal positive $CD79{\alpha}$. Based on gross, histologic, and immunohistochemical findings, the neoplasm was diagnosed a lymphocyte predominant thymoma.

키워드

참고문헌

  1. Moffet AC. Metastatic thymoma and acquired generalized myasthenia gravis in a beagle. Can Vet J 2007; 48: 91-93.
  2. Amarilla SP, Grau I. Mixed thymoma in a German Shepherd dog. Braz J Vet Pathol 2008; 1: 73-76.
  3. Birchard SJ, Couto GC, Samii VF, Weisbrode SE, Young GS. Results of excision of thymoma in cats and dogs: 20 cases (1984-2005). J Am Vet Med Assoc 2008; 232: 1186-1192. https://doi.org/10.2460/javma.232.8.1186
  4. Chan JKC. The thymus. In: Diagnostic Histopathology of Tumors, 3rd ed. Churchill Livingstone. 2007: 1270-1315.
  5. Yoon JH, Feeney DA, Cronk DE, Anderson KL, Ziegler LE. Computed tomographic evaluation of canine and feline mediastinal masses in 14 patients. Vet Radiol Ultrasound 2004; 45: 542-546. https://doi.org/10.1111/j.1740-8261.2004.04093.x
  6. Fossum TW, Hedlund CS, Julse DA. Thymomas and thymic branchial cysts. In: Small Animal Medicine, 2nd ed. Mosby. 2002: 818-819.
  7. Jacobs RM, Couto CG. A comparison between the cytological and histological characteristics in thirteen canine and feline thymomas. Can Vet J 1989; 30: 497.
  8. Jacobs RM, Messick JB, Valli VE. Tumors of the hemolymphatic system. In: Tumors in Domestic Animals, 4th ed. Wiley-Blackwell. 2002: 119-198.
  9. Lainesse MF, Taylor SM, Myers SL, Haines D, Fowler JD. Focal myasthenia gravis as a paraneoplastic syndrome of canine thymoma improvement following thymectomy. J Am Anim Hosp Assoc 1996; 32: 111-117.
  10. Langohr IM, Tury E, Santos HL, Jacobina GC. Mixed thymoma in a cow. J Vet Diag Invest 2006; 18: 503. https://doi.org/10.1177/104063870601800518
  11. Mellanby RJ, Mellor PJ, Herrtage ME. What is your diagnosis? Thymoma. J Small Anim Pract 2004; 45: 589, 626-8.
  12. Migaki G. Types of tumors found by federal meat inspectors in an eight-year survey. Ann N Y Acad Sci 1963; 108: 872-879.
  13. Parry B, Holloway S. Acquired myasthenia gravis associated with a non-invasive thymic carcinoma in a dog. Aust Vet J 2003; 81: 543-546. https://doi.org/10.1111/j.1751-0813.2003.tb12883.x
  14. Hylands R. Veterinary diagnostic imaging. Thymoma. Can Vet J 2006; 47: 593-596.
  15. Schwarz T, Vignoli M, Rodriguez D. Computed tomographic features of lung lobe torsion. Vet Radiol Ultrasound 2008; 49: 504-508. https://doi.org/10.1111/j.1740-8261.2008.00435.x
  16. Silke H. Thorax. In: Atlas of Small Animal Ultrasonography, 1st ed. Wiley-Blackwell. 2008: 130-131.
  17. Spaulding K. Sonographic evaluation of the cranial mediastinum in small animals. Vet Radiol Ultrasound 1991; 32: 178-184. https://doi.org/10.1111/j.1740-8261.1991.tb00104.x
  18. Tidwell A, Hecht S. Radiographic diagnosis of lung lobe torsion. Vet Radiol Ultrasound 2005; 46: 478-484. https://doi.org/10.1111/j.1740-8261.2005.00087.x
  19. Uchid K, Awamura Y, Nakamura T, Yamaguchi R, Tateyama S. Thymoma and multiple thymic cysts in a dog with acquired myasthenia gravis. J Vet Med Sci 2002; 64: 637-640. https://doi.org/10.1292/jvms.64.637
  20. Wright J, Brawner W. Radiation therapy in the treatment of canine and feline thymomas: a retrospective study (1985-1999). J Am Anim Hosp Assoc 2001; 37: 489.