Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Expression of Nerve Growth Factor in Estradiol Valerate-induced Polycystic Ovary Syndrome

Estradiol valerate에 의해 유발되는 다낭성난소증후군의 Nerve Growth Factor 변화

  • Kim, Se-Eun (College of Veterinary Medicine, Chonnam National University) ;
  • Lim, Sung-Chul (Department of Pathology, College of Medicine, Chosun University) ;
  • Jeong, Moon-Jin (Department of Oral Histology, School of Dentistry, Chosun University) ;
  • Choi, Baik-Dong (Department of Oral Histology, School of Dentistry, Chosun University) ;
  • Kim, Seung-Hyun (College of Veterinary Medicine, Chonnam National University) ;
  • Ko, A-Ra (College of Veterinary Medicine, Chonnam National University) ;
  • Seo, Seung-Yong (Department of Pathology, College of Medicine, Chosun University) ;
  • Kang, Seong-Soo (College of Veterinary Medicine, Chonnam National University) ;
  • Moon, Chang-Jong (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Jong-Choon (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Sung-Ho (College of Veterinary Medicine, Chonnam National University) ;
  • Bae, Chun-Sik (College of Veterinary Medicine, Chonnam National University)
  • 김세은 (전남대학교 수의과대학) ;
  • 임성철 (조선대학교 의과대학 병리학교실) ;
  • 정문진 (조선대학교 치과대학 구강조직학교실) ;
  • 최백동 (조선대학교 치과대학 구강조직학교실) ;
  • 김승현 (전남대학교 수의과대학) ;
  • 고아라 (전남대학교 수의과대학) ;
  • 서승용 (조선대학교 의과대학 병리학교실) ;
  • 강성수 (전남대학교 수의과대학) ;
  • 문창종 (전남대학교 수의과대학) ;
  • 김종춘 (전남대학교 수의과대학) ;
  • 김성호 (전남대학교 수의과대학) ;
  • 배춘식 (전남대학교 수의과대학)
  • Accepted : 2011.04.11
  • Published : 2011.08.30
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Abstract

A form of polycystic ovary (PCO) resembling some aspects of the human PCO syndrome (PCOS) can be induced in rats by a single injection of estradiol valerate (EV). An increase in sympathetic outflow to the ovary precedes, by several weeks, the appearance of cysts, suggesting the involvement of a neurogenic component in the pathology of this ovarian dysfunction. To test the hypotheses that the change in sympathetic tone is related to an augmented production of hippocampal and/or ovarian nerve growth factor (NGF), and that this abnormally elevated production of NGF contributes to the induction of PCOS induced by EV. The animals were sacrificed after PCOS induction and the ovaries and hippocampus were sectioned and compared to the normal control. The expression of NGF was measured by immunohistochemical staining and Western blot analysis in the ovaries and hippocampus. EV-induced PCOS showed significant increase of ovarian NGF expression. Immunohistochemical expression of NGF was confined to the follicular cells and interstitial cells. Hippocampal NGF expression was not significantly changed. In conclusion EV-induced PCOS was related to the ovarian sympathetic activation which was mediated by NGF.

Keywords

References

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