Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Phytochemical Constituents Isolated from the Stems of Chaenomeles sinensis Koehne

모과나무 줄기의 화학성분

  • Shin, Ji-Eun (College of Pharmacy, Chosun University) ;
  • Jin, Qing-Long (College of Pharmacy, Chosun University) ;
  • Jin, Hong-Guang (College of Pharmacy, Chosun University, Republic of Korea, & College of Pharmacy, Jilin Medical College) ;
  • Woo, Eun-Rhan (College of Pharmacy, Chosun University)
  • 신지은 (조선대학교 약학대학) ;
  • 김청룡 (조선대학교 약학대학) ;
  • 김홍광 (조선대학교 약학대학 & 길림의약학원 약학원) ;
  • 우은란 (조선대학교 약학대학)
  • Received : 2011.06.21
  • Accepted : 2011.08.11
  • Published : 2011.09.30
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Abstract

Chaenomeles sinensis Koehne (Rosaceae) is a deciduous tree and is distributed in China, Korea and Japan. In previous studies on the fruits of C. sinensis, some triterpenoid compouds such as oleanolic acid, tormentic acid were reported. In an ongoing investigation into biologically active compounds from natural products, the methanol extract of the stems of C. sinensis was investigated. By means of the repeated column chromatography using silica gel, Sephadex LH-20, LiChroprep RP-18, betulin (1), tormentic acid (2), 1-${\beta}$-D-glucopyranosyl-3,4,5-trimethoxybenzene (3), lyoniresinol-2a-O-${\alpha}$-L-rhamnopyranoside (4) were isolated. The chemical structures of compounds 1-4 were determined by the basis of physico-chemical properties and spectroscopic methods such as 1D and 2D NMR. For the isolated compounds (1-4), the inhibitory activity of IL-6 production in TNF-${\alpha}$ stimulated MG-63 cell was examined. Among the isolates, betulin (1), 1-${\beta}$-D-glucopyranosyl-3,4,5-trimethoxybenzene (3), lyoniresinol-2a-O-${\alpha}$-L-rhamnopyranoside (4) showed inhibitory effects on IL-6 production in TNF-${\alpha}$ stimulated MG-63 cell.

Keywords

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