Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Antinociceptive Effect of the Stem of Polygonum multiflorum

  • Lee, Se-Youn (College of Pharmacy, Woosuk University) ;
  • Kim, Jin-Kyu (College of Pharmacy, Woosuk University) ;
  • Kim, Jong-Soo (College of Pharmacy, Woosuk University) ;
  • So, Un-Ki (Department of Biotechnology, Graduate School, Woosuk University) ;
  • Oh, Chan-Ho (Department of Biotechnology, Graduate School, Woosuk University) ;
  • Jeon, Hoon (College of Pharmacy, Woosuk University)
  • Received : 2011.07.20
  • Accepted : 2011.09.05
  • Published : 2011.09.30
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Abstract

Polygoni multiflori Ramulus, the stem of Polygonum multiflorum Thunb., has been widely used as a traditional medicine for the treatment of many diseases. Presently, antinociceptive tests of the butanolic fraction of P. multiflorum (SPB) were performed using several thermal and chemical pain models. SPB had strong and dosedependent antinociceptive activities, both thermal and chemical, compared to the reference drugs Tramadol and Indomethacin. In combination with naloxone, the analgesic activity of SPB was unchanged indicating that the antinociceptive activity of SPB was not due to action as an opioid receptor agonist. The present results indicate the potential of SPB as an analgesic agent for pain control.

Keywords

References

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