Natural Product Sciences

  • 제17권3호
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  • Pages.189-197
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  • 2011
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  • 1226-3907(pISSN)
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  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

Protective Effect of Puerariae Radix on Ovariectomy-induced Bone Loss in Rats

  • Park, Jeong-A (Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Lee, Sung-Ok (Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Moon, Eun-Jung (Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Kim, May (Korea International School) ;
  • Lim, Seong-Cheol (Dongjea Herbal Clinic) ;
  • Cho, Min-Hyoung (Department of Biomedical Engineering, College of Electronics and Information, Kyung Hee University) ;
  • Kim, Sun-Yeou (Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University)
  • 투고 : 2011.05.12
  • 심사 : 2011.08.13
  • 발행 : 2011.09.30
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초록

To examine the bone-protective effects of Puerariae Radix (PR) in an estrogen-deficient animal model, we treated ovariectomized rats with PR at a dose of 10.0 mg/kg 3 times a week for 16 weeks. Our results showed that PR increased mineral content and density of the trabecular bone at the neck of the left femur. Moreover, biochemical data indicated that PR had a positive effect on bone turnover. No endometrial hyperplasia was detected in the PR group. The present data suggest that PR should be considered for use in the treatment of bone loss in women with postmenopausal osteoporosis.

키워드

참고문헌

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