The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
권호 표지
DOI QR코드

DOI QR Code

A Study of the Relationship between Granulocyte/Lymphocyte Ratio and Dysmenorrhea, History of Gynecological Disease, Heart Rate Variability in Some Young Women

과립구/림프구 비율과 일부 젊은 여성들의 월경양상, 산부인과적 질환 과거력 유무, HRV와의 관계

  • 허수정 (제인한방병원 한방부인과) ;
  • 장석우 (제인한방병원 한방부인과) ;
  • 김지영 (제인한방병원 한방신경정신과) ;
  • 조현주 (제인한방병원 한방부인과)
  • Received : 2011.07.29
  • Accepted : 2011.08.08
  • Published : 2011.08.31
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: The purpose of this study is to investigate the relationship between granulocyte/lymphocyte ratio and dysmenorrhea, history of gynecological disease, heart rate varibility(HRV). Methods: From May 1st 2011 to July 10th 2011, a total of 40 female subjects (age 20-39) were recruited. We evaluated the menstruation condition by questionnaires including VAS(Visual Analog Scale), VRS(Verbal Rating Scale) and MVRS (Multidimensional Verbal Rating Scale), also measured subject's WBC differential count and HRV. Results: 1. There was no statistically significant difference in granulocyte/lymphocyte ratio according to menstruation cycle, duration, amount, color, and blood clot. 2. There was no statistically significant difference in VAS, VRS, MVRS mean scores between normal group and abnormal group according to granulocyte/ lymphocyte ratio. 3. The past prevalence of gynecological disease of abnormal group showed significantly higher compared with that of normal group($x^2$=6.578, p=0.010). 4. LF/HF ratio and granulocyte ratio significantly showed positive correlation ($r_s$=0.311 p=0.048) and LF/HF ratio and lymphocyte ratio significantly showed negative correlation($r_s$=-0.319 p=0.045). Conclusion: These findings suggest that the gynecologic diseases are related to disorder of autonomic nervous system, but not dysmenorrhea. And the balance state of sympathetic/parasympathetic nerve infered through granulocyte/lymphocyte ratio and HRV seems to be consistent. However, reconfirmation through further studies is needed.

Keywords

References

  1. 채윤병 등. 침과 자율신경계 고찰: 인체의 심박변이도 중심으로. 경락경혈학회지. 2007;24(4):25-36.
  2. Pagani M et al. Sympathetic overactivity in subjects complaining of unexplained fatigue. Clin Sci. 1994;87(6):655-61. https://doi.org/10.1042/cs0870655
  3. Toru Abo, Toshihiko Kawamura. Immunomodulation by the Autonomic Nervous System: Therapeutic Approach for Cancer, Collagen Disease, and Inflammatory Bowel Disease. Therapeutic Apheresis. 2002;6(5):348-57. https://doi.org/10.1046/j.1526-0968.2002.00452.x
  4. 윤종천, 정인철, 이상룡. 자율신경 안정을 통한 불면증 치료. 대전대학교 한의학연구소 논문집. 2009;18(2):141-5.
  5. 최명애 등. 스트레스와 면역. 서울:군자출판사. 2003:267-75.
  6. Kawamura, T., Fukuda, M., Abo, T. Suppressive effect of antiulcer agents on granulocytes-a role of granulocytes for gastric ulcer formation. Digest. Dis. Sci. 2000;45(9):1786-91. https://doi.org/10.1023/A:1005526126694
  7. Tsukahara A, Tada T, Abo T. Adrenergic stimulation simultaneously induces the expansion of granulocytes and extrathymic T cells in mice. Biomed Res. 1997;18:237-46. https://doi.org/10.2220/biomedres.18.237
  8. 김영설, 박영배. 자율신경기능진단. 서울:군자출판사. 2007:24-37, 172-86.
  9. Tamaki Matsumoto et al. Altered autonomic nervous system activity as a potential etiological factor of premenstrual syndrome and premenstrual dysphoric disorder. Biopsychosoc Med. 2007;1(24):1-8. https://doi.org/10.1186/1751-0759-1-1
  10. 정재혁 등. 무월경 환자의 DITI와 HRV, 체성분 분석을 통한 특성 연구. 대한한방부인과학회지. 2009;22(4):94-101.
  11. 박경선 등. 월경전 증후군(PMS) 환자의 Heart Rate Variability(HRV) 특성에 관한 연구. 대한한방부인과학회지. 2008;21(3):99-110.
  12. 이지영 등. 일부 월경통 환자의 스트레스 반응 척도와 심박변이도상의 특징 고찰. 대한한방부인과학회지. 2008;21(1):216-30.
  13. 허자경 등. HRV(Heart Rate Variability) 측정을 통한 희발월경 환자의 자율 신경기능에 관한 연구. 대한한방부인과학회지. 2007;20(4):101-10.
  14. 박정경 등. 일부 산모의 기허상태와 CBC 및 HRV의 관계연구. 대한한방부인과학회지. 2008;21(1):231-41.
  15. 박가영, 김태희. 30대 초반의 초산, 경산부의 CBC 및 HRV 비교. 대한한방부인과학회지. 2008;21(4):128-38.
  16. Kamath MV, Fallen EL. Power spectral analysis of heart rate variability: a noninvasive signature of cardiac autonomic function. Crit Rev Biomed Eng. 1993;21(3):245-311.
  17. 이인선, 김미진, 김규곤. 월경량 평가 기준에 관한 연구. 대한한방부인과학회지. 2005;18(1):242-52.
  18. Mehmud G, Akhtar T, Sadia S. Endometriosis: frequency and correlation between symptomatology and disease stage. J Coll Physicians Surg Pak. 2007;17(4):199-202.
  19. Sundell G, Milsom I, Andersch B. Factors influencing the prevalence and severity of dysmenorrhea in young women. Br J Obstet Gynaecol. 1990;97(7):588-94. https://doi.org/10.1111/j.1471-0528.1990.tb02545.x
  20. 차지혜, 김윤상, 임은미. 일개 대학 신입생의 월경양상과 월경통 관련인자에 대한 연구. 대한한방부인과학회지. 2010;23(4):117-29.
  21. 김현정, 김윤상, 임은미. 저소득층 여성의 스트레스와 월경의 실태분석 및 상관관계 연구. 대한한방부인과학회지. 2009;22(4):136-49.
  22. 이지은 등. 자궁내막증 환자에서 타액 내 코르티졸 농도를 이용한 스트레스와 증상과의 상관관계에 대한 연구. 대한산부인과학회지. 2007;50(1):187-94.
  23. Toru Abo et al. Relationship Between Diseases Accompanied by Tissue Destruction and Granulocytes with Surface Adrenergic Receptors. Immunologic Research. 2007;37(3):201-10. https://doi.org/10.1007/BF02697370
  24. 대한진단검사의학회. 진단검사의학 제 3판. 서울:고려의학. 2001:237-45.
  25. 양동훈, 박영배. 맥파와 심박변이도의 상관성 연구. 대한한의진단학회지. 2006;10(2):104-20.

Cited by

  1. 일부 산모의 산과적 지표와 과립구/림프구 비와의 관계 vol.26, pp.4, 2011, https://doi.org/10.15204/jkobgy.2013.26.4.082