Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Angelicae Gleditsiae Spina on Polycystic Ovary Induced by Estradiol Valerate in Rats

조각자(皂角刺)가 Estradiol valerate에 의하여 유발된 다낭성난소에 미치는 영향

  • Shin, Dong-Sung (School of Korean Medicine, Pusan National University) ;
  • Kim, Hyung-Woo (School of Korean Medicine, Pusan National University) ;
  • Cho, Su-In (School of Korean Medicine, Pusan National University) ;
  • An, Won-Gun (School of Korean Medicine, Pusan National University)
  • 신동선 (부산대학교 한의학전문대학원) ;
  • 김형우 (부산대학교 한의학전문대학원) ;
  • 조수인 (부산대학교 한의학전문대학원) ;
  • 안원근 (부산대학교 한의학전문대학원)
  • Received : 2011.06.16
  • Accepted : 2011.08.12
  • Published : 2011.08.25
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Abstract

This study was designed to investigate the effects of Gleditsiae Spina (GS) on polycystic ovary (PCO) induced by estradiol valerate in female rats. We investigated the effects of GS on changes in body weights and food and water uptake for 5 weeks. In addition, we also examined the effects on ovary weights. Finally, we observed histopathological changes in PCO rats. Treatment with GS did not affect body weights, amount of food and water uptake compared with non-treated control group. Administration group of GS restored body/ovary weight ratio to normal levels, which were lowered by induction of PCO. In histopathological observation, formation of cysts was suppressed in GS group compared with non-treated control group. These results suggest that GS can be used for patients with PCO to prevent formation of cystic follicles and malfunction of ovary.

Keywords

References

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