The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effect of Citri Pericarpium ethanol extract on collagen-induced arthritis in mice

진피(陳皮) 에탄올추출물의 콜라겐 유도 관절염 마우스에서의 항관절염 효과 연구

  • Jung, Jin-Ki (Department of Herbology, College of Oriental Medicine, Dongguk University) ;
  • Son, Kun-Ho (Department of Food Science and Nutrition, Andong National University) ;
  • Kim, Young-Shik (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Park, Yong-Ki (Department of Herbology, College of Oriental Medicine, Dongguk University)
  • 정진기 (동국대학교 한의과대학 본초학교실) ;
  • 손건호 (안동대학교 생활과학대학 식품영양학과) ;
  • 김영식 (서울대학교 약학대학 천연물과학연구소) ;
  • 박용기 (동국대학교 한의과대학 본초학교실)
  • Received : 2011.08.15
  • Accepted : 2011.09.17
  • Published : 2011.09.30
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Abstract

Objectives : The present study was undertaken to determine whether an ethanol extract of Citri Pericarpium (CP-E), which is the pericarp of Citrus unshiu Markovich is efficacious against collagen-induced arthritis (CIA) in mice. Methods : CIA was induced in male DBA/1J mice by intradermal injection of bovine collagen-II in Freund's incomplete adjuvant (IFA). The mice in the onset of arthritis were treated daily with oral administration of CP-E ethanol extract at different doses (50 and 100 mg/kg/bw) for 28 days. Arthritis index, histopathologic changes and the levels of TNF-${\alpha}$ as well as anti-CII IgG in blood were evaluated to confirm the anti-arthritic effect of CP-E on CIA in rats. Results : The results showed that comparing with untreated CIA mice, treated with CP-E extract significantly decreased the arthritic scores and the pathological changes of knee joint tissues, and also reduced the serum levels of TNF-${\alpha}$ and anti-CII IgG in CIA-mice. These results indicate that CP-E extract may effectively alleviate inflammatory response on CIA, and its anti-inflammation can be attributed, at least partially, to the inhibition of proinflamamtory cytokine, TNF-${\alpha}$ in CIA. Conclusions : This study suggest that CP-E has a therapeutic potential in inflammatory joint diseases such as rheumatoid arthritis.

Keywords

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