Journal of Radiation Industry (방사선산업학회지)

Korean Society of Radiation Industry (한국방사선산업학회)
권호 표지

Surface Modification of Poly(L-lactide-co-ε-caprolactone) Nanofibers by Electron-beam Irradiation

전자선 조사 방법을 통한 생분해성고분자의 표면개질 특성 평가

  • Kim, Woo-Jin (Research Division for Industry & Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Shin, Young Min (Research Division for Industry & Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Park, Jong-Seok (Research Division for Industry & Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Gwon, Hui-Jeong (Research Division for Industry & Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Nho, Young-Chang (Research Division for Industry & Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Lim, Youn-Mook (Research Division for Industry & Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
  • 김우진 (한국원자력연구원 첨단방사선연구소 공업환경연구부) ;
  • 신영민 (한국원자력연구원 첨단방사선연구소 공업환경연구부) ;
  • 박종석 (한국원자력연구원 첨단방사선연구소 공업환경연구부) ;
  • 권희정 (한국원자력연구원 첨단방사선연구소 공업환경연구부) ;
  • 노영창 (한국원자력연구원 첨단방사선연구소 공업환경연구부) ;
  • 임윤묵 (한국원자력연구원 첨단방사선연구소 공업환경연구부)
  • Received : 2011.11.14
  • Accepted : 2011.12.12
  • Published : 2011.12.30

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Abstract

Electrospun nanofibers prepared with synthetic biodegradable polymer have some limitations in regulating adhesion, proliferation, and spreading of cells because of their surface hydrophobicity and absence of cell-interaction. In this study, we functionalized the electrospun poly(L-lactide-co-${\varepsilon}$-caprolactone) (PLCL) nanofibers with acrylic acid (AAc) to modulate their surface hydrophilicity using electron-beam irradiation method and then measured grafting ratio of AAc, water contact angle, and ATR-FTIR of AAc-grafted nanofibers. A grafting ratio of AAc on the nanofibers was increased as irradiation dose and AAc concentration were increased. AAc-grafted nanofibers also have higher wettability than non-modified nanofibers. In conclusion, those surface-modified nanofibers may be an essential candidate to regulate cell attachment in tissue engineering applications.

Keywords

Acknowledgement

Supported by : 교육과학기술부