Annals of Clinical Neurophysiology

The Korean Society of Clinical Neurophysiology (대한임상신경생리학회)
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Gastrointestinal Pseudoobstruction and Sensory Neuronopathy in Small Cell Lung Cancer

거짓 장막힘과 감각신경세포병증으로 발현된 소세포폐암 1예

  • Lee, Hyun-Jeong (Department of Neurology, Eulji University Hospital, Eulji University School of Medicine) ;
  • Choi, Young-Chul (Department of Neurology, Eulji University Hospital, Eulji University School of Medicine) ;
  • Yun, Dong-Joo (Department of Neurology, Eulji University Hospital, Eulji University School of Medicine) ;
  • Ko, Young-Chai (Department of Neurology, Eulji University Hospital, Eulji University School of Medicine) ;
  • Jang, Sang-Hyun (Department of Neurology, Eulji University Hospital, Eulji University School of Medicine) ;
  • Yoon, Soo-Jin (Department of Neurology, Eulji University Hospital, Eulji University School of Medicine) ;
  • Oh, Gun-Sei (Department of Neurology, Eulji University Hospital, Eulji University School of Medicine) ;
  • Lee, Soo-Joo (Department of Neurology, Eulji University Hospital, Eulji University School of Medicine)
  • 이현정 (을지대학교 의과대학 을지대학병원 신경과) ;
  • 최영철 (을지대학교 의과대학 을지대학병원 신경과) ;
  • 윤동주 (을지대학교 의과대학 을지대학병원 신경과) ;
  • 고영채 (을지대학교 의과대학 을지대학병원 신경과) ;
  • 장상현 (을지대학교 의과대학 을지대학병원 신경과) ;
  • 윤수진 (을지대학교 의과대학 을지대학병원 신경과) ;
  • 오건세 (을지대학교 의과대학 을지대학병원 신경과) ;
  • 이수주 (을지대학교 의과대학 을지대학병원 신경과)
  • Received : 2011.09.16
  • Accepted : 2011.11.29
  • Published : 2011.12.30
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Abstract

Subacute sensory neuronopathy and gastrointestinal pseudoobstruction are considered classical paraneoplastic neurological syndromes. We report a 56-year-old male who presented with typical symptoms of subacute sensory neuronopathy and autonomic neuropathy with gastrointestinal pseudoobstruction. The biopsy of the palpable supraclavicular lymph node revealed a small cell lung cancer. To our knowledge, intestinal pseudoobstruction and sensory neuronopathy in a small cell lung cancer have not been reported in Korea.

Keywords

References

  1. Shin JH, Jo HJ, Kim DS, Jung DS, Park KH, Lee MK, et al. A case of anti-Hu associated paraneoplastic subacute sensory neuronopathy. J Korean Neurol Assoc 2002;20:89-92.
  2. Smith BE, Windebank AJ. Dorsal root ganglion disorders. In: Katirji B, Kaminski HJ, Preston DC, Ruff RL, Shapiro BE. Neuromuscular disorders in clinical practice. Boston: Butterworth- Heinemann. 2002;478-500.
  3. Antoine J-C, Camdessanche J-P. Peripheral nervous system involvement in patients with cancer. Lancet Neurol 2007;6:75-86. https://doi.org/10.1016/S1474-4422(06)70679-2
  4. Molinuevo JL, Graus F, Serrano C, Rene R, Guerrero A, Illa I. Utility of anti Hu antibodies in the diagnosis of paraneoplastic sensory neuropathy. Ann Neurol 1998;44:976-980. https://doi.org/10.1002/ana.410440620
  5. Graus F, Delattre J, Antoine J, Dalmau J, Giometto B, Grisold W, et al. Recommended diagnostic criteria for paraneoplastic neurological syndromes. J Neurol Neurosurg Psychiatry 2004;75:1135-1140. https://doi.org/10.1136/jnnp.2003.034447
  6. Henson RA, Urich H. Part III. Paraneoplastic disorders. In: Henson RA, Urich H. Cancer and the nervous system. Oxford: Blackwell Scientific Publications, 1982;311-451.
  7. Lennon V, Sas D, Busk M, Scheithauer B, Malagelada JR, Camilleri M, et al. Enteric neuronal autoantibodies in pseudoobstruction with small-cell lung carcinoma. Gastroenterology 1991;100:137-142. https://doi.org/10.1016/0016-5085(91)90593-A
  8. Gong Y, Tagawa Y, Lunn M, Laroy W, Heffer Lauc M, Li C, et al. Localization of major gangliosides in the PNS: implications for immune neuropathies. Brain 2002;125:2491-2506. https://doi.org/10.1093/brain/awf258
  9. Pan CL, Yuki N, Koga M, Chiang MC, Hsieh ST. Acute sensory ataxic neuropathy associated with monospecific anti-GD1b IgG antibody. Neurology 2001;57:1316-1318. https://doi.org/10.1212/WNL.57.7.1316
  10. De Toni L, Marconi S, Nardelli E, Alberti D, Borsellino G, Fracasso G, et al. Gangliosides act as onconeural antigens in paraneoplastic neuropathies. J Neuroimmunol 2004;156:178-187. https://doi.org/10.1016/j.jneuroim.2004.07.020