Applied Chemistry (응용화학)

The Korean Society of Industrial and Engineering Chemistry (한국공업화학회)
권호 표지

Spectrofluorimetric Determination of Levodopa through Ternary Complex Formation with Europium(III) and Ethylenediaminetetraacetic Acid

Europium(III)와 EDTA의 3차 복합체 형성에 의한 Levodopa의 분광분석적 정량

  • Kamruzzaman, Mohammad (Department of Chemistry, Kyungpook National University) ;
  • Alam, MD R-Mahmnur (Department of Chemistry, Kyungpook National University) ;
  • Kim, So Yeon (Department of Chemistry, Kyungpook National University) ;
  • Jo, Hae Jin (Department of Chemistry, Kyungpook National University) ;
  • Lee, Sang Hak (Department of Chemistry, Kyungpook National University) ;
  • Kim, Young Ho (Research Institute of Advanced Energy Technology, Kyungpook National University) ;
  • Kim, Sung Hong (Korea Basic Science Institute Daegu Center)
  • Published : 2011.03.31

⟨ Previous Next ⟩

Abstract

A highly sensitive spectrofluorimetric method was developed for the determination of levodopa based on the formation of a ternary complex with Eu3+ in the presence of ethylenediaminetetraacetic acid. It was found that this complex manifests intense fluorescence at 591 and 613 nm with excitation at 372 nm and maximum intensity was obtained at 613 nm. Under the optimum conditions, the enhanced fluorescence intensity was proportional to the concentration of levodopa over the range of 3×10-9-2.5×10-7 mol L-1 with limit of detection (LOD) of 4.37×10-10 mol L-1. The method offers higher sensitivity and selectivity which could be effectively applied for the determination of levodopa in pharmaceutical and biological samples.

Keywords

Acknowledgement

This work was supported by the Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2009-0093819).