Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지
DOI QR코드

DOI QR Code

Spontaneous Multicentric Malignant Schwannoma in a Male Fischer 344 Rat

  • Received : 2011.04.06
  • Accepted : 2011.07.28
  • Published : 2011.09.01
Download PDF
⟨ Previous Next ⟩

Abstract

We describe here a multicentric spontaneous malignant schwannoma obtained from one male F344 rat, and this animal was the subject of a carcinogenicity study for which it was treated with diisodecyl phthalate. The animal of the control group not treated with diisodecyl phthalate showed dyspnea and severe lordosis. On the necropsy, two tan, firm, encapsulated masses were observed in the subcutis of the lumbosacral region and the left inguinal region of the abdominal cavity, respectively; the masses were $25{\times}17{\times}8$ mm and $16{\times}14{\times}8$ mm in size, respectively. Histologically, the tumor consisted of spindle and pleomorphic cells that grew in various patterns, that was, sweeping fascicles and herringbone and local organoid patterns. The pleomorphic neoplastic cells had more than two nuclei. Additionally, the diagnosis of malignant schwannoma was confirmed by the immune reactivity of the tumor cells for S-100 protein.

Keywords

References

  1. Cho, W.S., Han, B.S., Ahn, B., Nam, K.T., Choi, M., Oh, S.Y., Kim, S.H., Jeong, J. and Jang, D.D. (2008). Peroxisome proliferator di-isodecyl phthalate has no carcinogenic potential in Fischer 344 rats. Toxicol. Lett., 178, 110-116. https://doi.org/10.1016/j.toxlet.2008.02.013
  2. Colmenero, C., Rivers, T., Patron, M., Sierra, I. and Gamallo, C. (1991). Maxillofacial malignant peripheral nerve sheath tumours. J. Craniomaxillofac. Surg., 19, 40-46. https://doi.org/10.1016/S1010-5182(05)80270-7
  3. Giangaspero, F., Fratamico, F.C., Ceccarelli, C. and Brisigotti, M. (1989). Malignant peripheral nerve sheath tumors and spindle cell sarcomas: an immunohistochemical analysis of multiple markers. Appl. Pathol., 7, 134-144.
  4. Gray, M.H., Rosenberg, A.E., Dickersin, G.R. and Bhan, A.K. (1989). Glial fibrillary acidic protein and keratin expression by benign and malignant nerve sheath tumors. Hum. Pathol., 20, 1089-1096. https://doi.org/10.1016/0046-8177(89)90228-1
  5. Goodman, D.G., Ward, J.M., Squire, R.A., Chu, K.C. and Linhart, M.S. (1979). Neoplastic and nonneoplastic lesions in aging F344 rats. Toxicol. Appl. Pharmacol., 48, 237-248. https://doi.org/10.1016/0041-008X(79)90029-2
  6. Haseman, J.K., Hailey, J.R. and Morris, R.W. (1998). Spontaneous neoplasm incidences in Fischer 344 rats and B6C3F1 mice in two-year carcinogenicity studies: a National Toxicology Program update. Toxicol. Pathol., 26, 428-441. https://doi.org/10.1177/019262339802600318
  7. Hruban, R.H., Shiu, M.H., Senie, R.T. and Woodruff, J.M. (1990). Malignant peripheral nerve sheath tumors of the buttock and lower extremity. A study of 43 cases. Cancer., 66, 1253-1265. https://doi.org/10.1002/1097-0142(19900915)66:6<1253::AID-CNCR2820660627>3.0.CO;2-R
  8. Johnson, M.D., Glick, A.D. and Davis, B.W. (1988). Immunohistochemical evaluation of Leu-7, myelin basic-protein, S100-protein, glial-fibrillary acidic-protein, and LN3 immunoreactivity in nerve sheath tumors and sarcomas. Arch. Pathol. Lab. Med., 112, 155-160.
  9. Kawahara, E., Oda, Y., Ooi, A., Katsuda, S., Nakanishi, I. and Umeda, S. (1988). Expression of glial fibrillary acidic protein (GFAP) in peripheral nerve sheath tumors. A comparative study of immunoreactivity of GFAP, vimentin, S-100 protein, and neurofilament in 38 schwannomas and 18 neurofibromas. Am. J. Surg. Pathol., 12, 115-120. https://doi.org/10.1097/00000478-198802000-00004
  10. Laber-Laird, K.E., Jokinen, M.P. and Jerome, C.P. (1988). Naturally occurring schwannoma in a Fischer 344 rat. Vet. Pathol., 25, 320-322. https://doi.org/10.1177/030098588802500414
  11. Rice, J.M. and Ward, J.M. (1988). Schwannomas (induced) cranial, spinal, and peripheral nerves, rat. pp. 154-160. In: ILSI Monographs on Pathology of Laboratory Animals. Nervous System, Eds. Jones, T., C, Mohr, U., and Hunt, R., D. New York. Springer-Verlag.
  12. Sharma, S., Sarkar, C., Mathur, M., Dinda, A.K. and Roy, S. (1990). Benign nerve sheath tumors: a light microscopic, electron microscopic and immunohistochemical study of 102 cases. Pathology, 22, 191-195. https://doi.org/10.3109/00313029009086659
  13. Weiss, S.W., Langloss, J.M. and Enzinger, F.M. (1983). Value of S-100 protein in the diagnosis of soft tissue tumors with particular reference to benign and malignant Schwann cell tumors. Lab. Invest., 49, 299-308.
  14. Yoshida, M. (1992). Malignant schwannoma arising from the trigeminal nerve in a rat.. J. Comp. Pathol., 106, 315-318. https://doi.org/10.1016/0021-9975(92)90059-4