DOI QR코드

DOI QR Code

Impact of the Radiation Absorbed dose on the Microelements of Tissues in Living Bodies

방사선 선량이 생체 내 조직에서 미량원소에 미치는 영향

  • 지태정 (가야대학교 방사선학과) ;
  • 곽병준 (춘해보건대학 방사선과)
  • Received : 2011.04.27
  • Accepted : 2011.07.11
  • Published : 2011.08.28

Abstract

We looked into the content change of microelements participating in the metabolism among the impacts of radiation energy on living bodies. We irradiated X-rays of 1 Gy, 5 Gy and 10 Gy to the whole bodies of mice, and then analyzed the liver tissues. We found that the microelement content had changed in some elements compared with the control group. When it came to changes by radiation dose, there was no significant change with the absorbed level of 1 Gy, but the higher absorbed levels of 5 Gy and 10 Gy reduced the content of Ca and Mn. In particular, the Ca content was reduced the most, apparently causing symptoms such as muscle tension and chronic headache, etc. The increased element was Al, which was found to have increased by 100%. In regard to the content change according to the time elapsed after irradiation, the contents of Fe, Ba, etc. showed the tendency of reduction. The content of Cd, a harmful element, increased by 25%, and it seemed that the element was involved in the calcium metabolism. Therefore, cell damage by radiation energy is determined to have an impact on the content change of microelements and considered to be partly related to a cause of precursor symptoms.

방사선에너지가 생체에 미치는 영향 중 물질대사에 관여하는 미량원소의 함량을 알아보았다. 실험 방법은 mouse에 1Gy, 5Gy, 10Gy의 X선을 전신 조사한 후 간 조직에서 분석하였다. 그 결과, 일부 원소에서 대조군과 비교하여 함량 변화가 확인되었다. 선량에 따른 변화에서는 1Gy에서는 크게 차이를 보이지 않았으나 5Gy, 10Gy의 높은 선량에서는 Ca, Mn의 함량이 감소되었다. 그 중 Ca의 함량이 가장 많이 감소되었으며, 근육 긴장과 만성 두통 등의 증후군을 유발하는 것으로 판단된다. 함량 증가를 보인 원소는 Al으로 100% 증가된 것으로 조사되었다. 방사선 조사 후 기간 경과에 따른 함량 변화에서는 Fe, Ba 등에서 감소하는 경향을 보였다. 유해원소는 Cd 함량이 25% 증가 되었는데 이는 칼슘대사에 관여하는 것으로 알려졌다. 따라서 방사선에너지에 의한 세포 손상이 미량원소 함량 변화에 영향을 주는 것으로 판단되며, 전구증상을 유발하는데 일정부분 관련이 있는 것으로 사료된다.

Keywords

References

  1. 김미경, 왕수경, 신동순, 권오란, "생활속의 영양학", 제2판, 라이프사이언스, pp.278-345, 2010.
  2. R, J. Williams, "The mineral elements in homoeostasis and morphogenesis," Biochem Soc Trans, Vol.18, No.5, pp.689-705, 1990. https://doi.org/10.1042/bst0180689
  3. D. K. Combs, R. D. Goodrich, and J. C. Meiske, "Mineral concentrations in hair as indicators of mineral status: a review," J Anim Sci, Vol.54, No.2, pp.391-398, 1982. https://doi.org/10.2527/jas1982.542391x
  4. M. Yasui, "Calcium and the degenerative neurological diseases," Clin Calcium, Vol.14, No.1, pp.110-117, 2004.
  5. 김소운, "생명의 균형 미네랄 3.5%" 북폴리오, 2005.
  6. O. Micke, L. Schomburg, J. Buentzel, K. Kisters, R. Muecke, "Selenium in oncology: from chemistry to clinics," Molecules, Vol.14, No.10, pp.3975-3988, 2009. https://doi.org/10.3390/molecules14103975
  7. A. A. Korolev, B. P. Sukhanov, I. P. Korenkov, A. V. Vasil'ev, Mal'tsev GIu, N. M. Merzliakova, Poliakov IuA, and L. A. Orlova, "Effects of mineral contents of a ration on indicators of radiation resistance of the body," Gig Sanit, Vol.3, pp.19-21, 1995.
  8. E. Kolb, E. Grün, K. Nestler, and S. Eichler, "Content of minerals (Na,K,Ca,Mg) and of trace elements (Fe,Cu and Zn) in 13 different tissues of fallow deer (Dama dama L.) of various ages," Berl Munch Tierarztl Wochenschr, Vol.114, No.3-4, pp.127-133, 2001.
  9. T. Saetersdal, H. Engedal, J. Røli, and R. Myklebust, "Calcium and magnesium levels in isolated mitochondria from human cardiac biopsies." Histochemistry, Vol.68, No.1, pp.1-8, 1980. https://doi.org/10.1007/BF00498494
  10. O. A. Levander, "Lead toxicity and nutritional deficiencies," Environ Health Perspect, Vol.29, pp.115-125, 1979. https://doi.org/10.1289/ehp.7929115
  11. Tolosa de Talamoni NG, "Calcium and phosphorous deficiencies alter the lipid composition and fluidity of intestinal basolateral membranes," Comp Biochem Physiol A Physiol, Vol.115, No.4, pp.309-315, 1996. https://doi.org/10.1016/S0300-9629(96)00083-7
  12. M. Hambidge, "Human zinc deficiency," J Nutr. Vol.130, pp.1344S-1349S, 2000. https://doi.org/10.1093/jn/130.5.1344S
  13. R. S. Lymbury, M. J.Marino, A. V. Perkins, "Effect of dietary selenium on the progression of heart failure in the ageing spontaneously hypertensive rat," Mol Nutr Food Res, Vol.54, No.10, pp.1436-1444, 2010. https://doi.org/10.1002/mnfr.201000012
  14. M. G. Boosalis, "The role of selenium in chronic disease," Nutr Clin Pract, Vol.23, No.2, pp.152-160, 2008. https://doi.org/10.1177/0884533608314532
  15. 지태정, "신장 조직의 방사선 손상과 천연물질의 방어기전 연구", 한국콘텐츠학회논문지, Vol.9, No.12, pp.297-304, 2009.
  16. 지태정, "알리인 투여 후 혈소판의 방사선 방어기전 연구", 방사선기술과학, Vol.33, No.3, pp.185-191, 2010.
  17. J. Zarocostas, "UNICEF calls for efforts to eradicate vitamin deficiency," Lancet, Vol.31, pp.363-378, 2004.
  18. 생노병사의 비밀, "생명의 원소 미네랄! 3.5%의 균형을 유지하라!", KBS, 2004,
  19. R. J. Williams, "Calcium", Methods Mol Biol, Vol.172, pp.21-49, 2002.
  20. S. A. Counter, L. H. Buchanan, H. D. Rosas, and F. Ortega, "Neurocognitive effects of chronic lead intoxication in Andean children," J Neurol Sci, Vol.18, No.1, pp.47-53, 1998.
  21. Q. G. Tan, W. X. Wang, "Acute toxicity of cadmium in Daphnia magna under different calcium and pH conditions: importance of influx rate," Environ Sci Technol, Vol.1, No.5, pp.1970-1976, 2011.
  22. R. S. Berger, J. L. Fu, K. A. Smiles, C. B. Turner, B. M. Schnell, K. M. Werchowski, and K. M. Lammers, "The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled tria," Br J Dermatol, Vol.149, No.2, pp.354-362, 2003. https://doi.org/10.1046/j.1365-2133.2003.05435.x
  23. T. J. JI, B. I. Min, and E. W. Seo, "Effect of Propolis on Blood Components and Tissues of Mouse after Low dose X-ray Irradiation," 대한의생명과학회지, Vol.12, No.1, pp.43-48, 2006.