DOI QR코드

DOI QR Code

Prevalence of porcine parvovirus in pigs with postweaning multisystemic wasting syndrome in Jeju Island

  • Ko, Kyeong-Nam (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) ;
  • Jung, Ji-Youl (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) ;
  • Kang, Sang-Chul (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) ;
  • Kim, Ki-Seung (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) ;
  • Kim, Jae-Hoon (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) ;
  • Kim, Dae-Yong (College of Veterinary Medicine, Seoul National University) ;
  • Hwang, Eui-Kyung (College of Life Science and Natural Resources, Sangji University) ;
  • Kim, Jae-Hoon (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University)
  • 투고 : 2010.05.27
  • 심사 : 2011.01.06
  • 발행 : 2011.09.30

초록

Postweaning multisystemic wasting syndrome (PMWS), which was first identified in western Canada in 1991 and more recently in the United States, Europe and Asia, is an emerging disease in pigs. Porcine circovirus type 2 (PCV-2) is the primary infectious viral agent causing PMWS, but the full expression of the disease may require the presence of other agents. It is reported that there is apparent synergism between PCV-2 and porcine parvovirus (PPV) in increasing the severity of the clinical signs and lesions of PMWS. From January 2006 to May 2008, a total of the 154 lymph node samples were collected from 4~12 weeks old pigs which had been submitted to the College of Veterinary Medicine, Jeju National University, Korea. These pigs were diagnosed as PMWS on the basis of clinical and pathological examination from 48 commercial herds in Jeju Island. Based on the immunohistochemistry, porcine parvovirus was detected in 69 cases (44.8%) from 154 weaned or grower pigs. PPV antigens were detected in the cytoplasm of histiocytic cells multifocally infiltrated in the cortex and paracortex of lymph nodes. The results of this study clarify that PPV is prevalent in pigs with PMWS on Jeju Island. Therefore PPV is one of the most important co-agents in the development of naturally acquired PMWS. This study may be helpful to the control of this disease and to epidemiological aspects.

키워드

참고문헌

  1. Allan GM, Ellis JA. Porcine circoviruses: a review. J Vet Diagn Invest 2000, 12, 3-14. https://doi.org/10.1177/104063870001200102
  2. Allan GM, Kennedy S, McNeilly F, Foster JC, Ellis JA, Krakowka SJ, Meehan BM, Adair BM. Experimental reproduction of severe wasting disease by co-infection of pigs with porcine circovirus and porcine parvovirus. J Comp Pathol 1999, 121, 1-11. https://doi.org/10.1053/jcpa.1998.0295
  3. Choi C, Chae C. Distribution of porcine parvovirus in porcine circovirus 2-infected pigs with postweaning multisystemic wasting syndrome as shown by in-situ hybridization. J Comp Pathol 2000, 123, 302-305. https://doi.org/10.1053/jcpa.2000.0421
  4. Ellis JA, Bratanich A, Clark EG, Allan G, Meehan B, Haines DM, Harding J, West KH, Krakowka S, Konoby C, Hassard L, Martin K, McNeilly F. Coinfection by porcine circoviruses and porcine parvovirus in pigs with naturally acquired postweaning multisystemic wasting syndrome. J Vet Diagn Invest 2000, 12, 21-27. https://doi.org/10.1177/104063870001200104
  5. Ellis J, Clark E, Haines D, West K, Krakowka S, Kennedy S, Allan GM. Porcine circovirus-2 and concurrent infections in the field. Vet Microbiol 2004, 98, 159-163. https://doi.org/10.1016/j.vetmic.2003.10.008
  6. Ellis J, Hassard L, Clark E, Harding J, Allan G, Willson P, Strokappe J, Martin K, McNeilly F, Meehan B, Todd D, Haines D. Isolation of circovirus from lesions of pigs with postweaning multisystemic wasting syndrome. Can Vet J 1998, 39, 44-51.
  7. Harding MJ, Molitor TW. Porcine parvovirus: replication in and inhibition of selected cellular functions of swine alveolar macrophages and peripheral blood lymphocytes. Arch Virol 1988, 101, 105-117. https://doi.org/10.1007/BF01314655
  8. Kennedy S, Moffett D, McNeilly F, Meehan B, Ellis J, Krakowka S, Allan GM. Reproduction of lesions of postweaning multisystemic wasting syndrome by infection of conventional pigs with porcine circovirus type 2 alone or in combination with porcine parvovirus. J Comp Pathol 2000, 122, 9-24. https://doi.org/10.1053/jcpa.1999.0337
  9. Kim J, Choi C, Chae C. Pathogenesis of postweaning multisystemic wasting syndrome reproduced by coinfection with Korean isolates of porcine circovirus 2 and porcine parvovirus. J Comp Pathol 2003, 128, 52-59. https://doi.org/10.1053/jcpa.2002.0605
  10. Kim J, Chung HK, Jung T, Cho WS, Choi C, Chae C. Postweaning multisystemic wasting syndrome of pigs in Korea: prevalence, microscopic lesions and coexisting microorganisms. J Vet Med Sci 2002, 64, 57-62. https://doi.org/10.1292/jvms.64.57
  11. Krakowka S, Ellis JA, Meehan B, Kennedy S, McNeilly F, Allan G. Viral wasting syndrome of swine: Experimental reproduction of postweaning multisystemic wasting syndrome in gnotobiotic swine by coinfection with porcine circovirus 2 and porcine parvovirus. Vet Pathol 2000, 37, 254-263. https://doi.org/10.1354/vp.37-3-254
  12. Meehan BM, McNeilly F, Todd D, Kennedy S, Jewhurst VA, Ellis JA, Hassard LE, Clark EG, Haines DM, Allan GM. Characterization of novel circovirus DNAs associated with wasting syndromes in pigs. J Gen Virol 1998, 79, 2171-2179. https://doi.org/10.1099/0022-1317-79-9-2171
  13. Mengeling WL. Porcine parvovirus. In: Straw BE, D'Allaire S, Mengeling WL, Taylor DJ (eds.). Diseases of Swine. 8th ed. pp. 187-200, Iowa State University Press, Ames, 1999.
  14. Opriessnig T, Fenaux M, Yu S, Evans RB, Cavanaugh D, Gallup JM, Pallares FJ, Thacker EL, Lager KM, Meng XJ, Halbur PG. Effect of porcine parvovirus vaccination on the development of PMWS in segregated early weaned pigs coinfected with type 2 porcine circovirus and porcine parvovirus. Vet Microbiol 2004, 98, 209-220. https://doi.org/10.1016/j.vetmic.2003.11.006
  15. Ostanello F, Caprioli A, Di Francesco A, Battilani M, Sala G, Sarli G, Mandrioli L, McNeilly F, Allan GM, Prosperi S. Experimental infection of 3-week-old conventional colostrum-fed pigs with porcine circovirus type 2 and porcine parvovirus. Vet Microbiol 2005, 108, 179-186. https://doi.org/10.1016/j.vetmic.2005.04.010
  16. Rose N, Abhervé-Guéguen A, Le Diguerher G, Eveno E, Jolly JP, Blanchard P, Oger A, Jestin A, Madec F. Effect of the Pietrain breed used as terminal boar on post-weaning multisystemic wasting syndrome (PMWS) in the offspring in four PMWS-affected farms. Livest Prod Sci 2005, 95, 177-186. https://doi.org/10.1016/j.livprodsci.2004.12.020
  17. Rose N, Blanchard P, Cariolet R, Grasland B, Amenna N, Oger A, Durand B, Balasch M, Jestin A, Madec F. Vaccination of porcine circovirus type 2 (PCV2)-infected sows against porcine parvovirus (PPV) and Erysipelas: effect on post-weaning multisystemic wasting syndrome (PMWS) and on PCV2 genome load in the offspring. J Comp Pathol 2007, 136, 133-144. https://doi.org/10.1016/j.jcpa.2007.01.006
  18. Segales J, Domingo M, Chianini F, Majo N, Dominguez J, Darwich L, Mateu E. Immunosuppression in postweaning multisystemic wasting syndrome affected pigs. Vet Microbiol 2004, 98, 151-158. https://doi.org/10.1016/j.vetmic.2003.10.007