References
- Aharoni R, Teitelbaum D, Sela M, Arnon R. Copolymer 1 induces T cells of the T helper type 2 that crossreact with myelin basic protein and suppress experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 1997, 94, 10821-10826. https://doi.org/10.1073/pnas.94.20.10821
- Aharoni R, Teitelbaum D, Sela M, Arnon R. Bystander suppression of experimental autoimmune encephalomyelitis by T cell lines and clones of the Th2 type induced by copolymer 1. J Neuroimmunol 1998, 91, 135-146. https://doi.org/10.1016/S0165-5728(98)00166-0
-
Barnes PJ, Karin M. Nuclear factor-
${\kappa}$ B: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997, 336, 1066-1071. https://doi.org/10.1056/NEJM199704103361506 -
Cai D, Frantz JD, Tawa NE Jr, Melendez PA, Oh BC, Lidov HGW, Hasselgren PO, Frontera WR, Lee J, Glass DJ, Shoelson SE.
$IKK{\beta}/NF-{\kappa}B$ activation causes severe muscle wasting in mice. Cell 2004, 119, 285-298. https://doi.org/10.1016/j.cell.2004.09.027 - Chen M, Gran B, Costello K, Johnson K, Martin R, Dhib-Jalbut S. Glatiramer acetate induces a Th2-biased response and crossreactivity with myelin basic protein in patients with MS. Mult Scler 2001, 7, 209-219. https://doi.org/10.1177/135245850100700401
- Duda PW, Schmied MC, Cook SL, Krieger JI, Hafler DA. Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis. J Clin Invest 2000, 105, 967-976. https://doi.org/10.1172/JCI8970
-
Flores N, Duran C, Blasco MR, Puerta C, Dorado B, Garcia-Merino A, Ballester S. NF
${\kappa}$ B and AP-1 DNA binding activity in patients with multiple sclerosis. J Neuroimmunol 2003, 135, 141-147. https://doi.org/10.1016/S0165-5728(02)00440-X - Fridkis-Hareli M, Teitelbaum D, Gurevich E, Pecht I, Brautbar C, Kwon OJ, Brenner T, Arnon R, Sela M. Direct binding of myelin basic protein and synthetic copolymer 1 to class II major histocompatibility complex molecules on living antigen-presenting cells--specificity and promiscuity. Proc Natl Acad Sci USA 1994, 91, 4872-4876. https://doi.org/10.1073/pnas.91.11.4872
- Gran B, Tranquill LR, Chen M, Bielekova B, Zhou W, Dhib-Jalbut S, Martin R. Mechanisms of immunomodulation by glatiramer acetate. Neurology 2000, 55, 1704-1714. https://doi.org/10.1212/WNL.55.11.1704
-
Grilli M, Chiu JJ, Lenardo MJ. NF-
${\kappa}$ B and Rel: participants in a multiform transcriptional regulatory system. Int Rev Cytol 1993, 143, 1-62. -
Henkel T, Machleidt T, Alkalay I, Kronke M, Ben-Neriah Y, Baeuerle PA. Rapid proteolysis of
$I{\kappa}B-{\alpha}$ is necessary for activation of transcription factor NF-${\kappa}$ B. Nature 1993, 365, 182-185. https://doi.org/10.1038/365182a0 -
Hilliard B, Samoilova EB, Liu TST, Rostami A, Chen Y. Experimental autoimmune encephalomyelitis in NF-
${\kappa}$ B-deficient mice: roles of NF-${\kappa}$ B in the activation and differentiation of autoreactive T cells. J Immunol 1999, 163, 2937-2943. -
Hwang I, Jee Y. Expression and Localization of phospho-I
${\kappa}$ B in the central nervous system during experimental autoimmune encephalomyelitis in Lewis rats. Korean J Vet Res 2005, 45, 7-15. -
Jee Y, Piao WH, Liu R, Bai XF, Rhodes S, Rodebaugh R, Campagnolo DI, Shi FD, Vollmer TL.
$CD4^{+}CD25^{+}$ regulatory T cells contribute to the therapeutic effects of glatiramer acetate in experimental autoimmune encephalomyelitis. Clin Immunol 2007, 125, 34-42. https://doi.org/10.1016/j.clim.2007.05.020 - Liang Q, Bueno OF, Wilkins BJ, Kuan CY, Xia Y, Molkentin JD. c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling. EMBO J 2003, 22, 5079-5089. https://doi.org/10.1093/emboj/cdg474
- Miller A, Shapiro S, Gershtein R, Kinarty A, Rawashdeh H, Honigman S, Lahat N. Treatment of multiple sclerosis with copolymer-1 (Copaxone): implicating mechanisms of Th1 to Th2/Th3 immunedeviation. J Neuroimmunol 1998, 92, 113-121. https://doi.org/10.1016/S0165-5728(98)00191-X
- Neuhaus O, Farina C, Yassouridis A, Wiendl H, Then Bergh F, Dose T, Wekerle H, Hohlfeld R. Multiple sclerosis: comparison of copolymer-1-reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells. Proc Natl Acad Sci USA 2000, 97, 7452-7457. https://doi.org/10.1073/pnas.97.13.7452
- Raine CS, Traugott U. Experimental autoimmune demyelination. Chronic relapsing models and their therapeutic implications for multiple sclerosis. Ann N Y Acad Sci 1984, 436, 33-51. https://doi.org/10.1111/j.1749-6632.1984.tb14774.x
- Riminton DS, Körner H, Strickland DH, Lemckert FA, Pollard JD, Sedgwick JD. Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, mice. J Exp Med 1998, 187, 1517-1528. https://doi.org/10.1084/jem.187.9.1517
-
Salminen A, Huuskonen J, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. Activation of innate immunity system during aging: NF-
${\kappa}$ B signaling is the molecular culprit of inflamm-aging. Ageing Res Rev 2008, 7, 83-105. https://doi.org/10.1016/j.arr.2007.09.002 - Schrempf W, Ziemssen T. Glatiramer acetate: mechanisms of action in multiple sclerosis. Autoimmun Rev 2007, 6, 469-475. https://doi.org/10.1016/j.autrev.2007.02.003
- Sha WC, Liou HC, Tuomanen EI, Baltimore D. Targeted disruption of the p50 subunit of NF-B leads to multifocal defects in immune responses. Cell 1995, 80, 321-330. https://doi.org/10.1016/0092-8674(95)90415-8
- Teitelbaum D, Fridkis-Hareli M, Arnon R, Sela M. Copolymer 1 inhibits chronic relapsing experimental allergic encephalomyelitis induced by proteolipid protein (PLP) peptides in mice and interferes with PLPspecific T cell responses. J Neuroimmunol 1996, 64, 209-217. https://doi.org/10.1016/0165-5728(95)00180-8
- Vanderlugt CL, Rahbe SM, Elliott PJ, Dal Canto MC, Miller SD. Treatment of established relapsing experimental autoimmune encephalomyelitis with the proteasome inhibitor PS-519. J Autoimmun 2000, 14, 205-211. https://doi.org/10.1006/jaut.2000.0370
- Vieira PL, Heystek HC, Wormmeester J, Wierenga EA, Kapsenberg ML. Glatiramer acetate (copolymer-1, copaxone) promotes Th2 cell development and increased IL-10 production through modulation of dendritic cells. J Immunol 2003, 170, 4483-4488. https://doi.org/10.4049/jimmunol.170.9.4483
- Wingren AG, Parra E, Varga M, Kalland T, Sjogren HO, Hedlund G, Dohlsten M. T cell activation pathways: B7, LFA-3, and ICAM-1 shape unique T cell profiles. Crit Rev Immunol 1995, 15, 235-253. https://doi.org/10.1615/CritRevImmunol.v15.i3-4.30