The Korean Journal of Pesticide Science (농약과학회지)

The Korean Society of Pesticide Science (한국농약과학회)
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Thirteen-Week Repeated Oral Toxicity Study of Leaf Folder (Cnaphalocrocis medinalis) Resistant Rice (Nakdongbyeb) in Sparague-Dawely Rats

SD 랫드에서 혹명나방 저항성 유전자 변형 낙동벼의 13주 경구 반복투여 독성에 관한 연구

  • 서동석 (호서대학교 안전성평가센터) ;
  • 권민 (호서대학교 안전성평가센터) ;
  • 성하정 (호서대학교 안전성평가센터) ;
  • 박철범 (호서대학교 안전성평가센터)
  • Received : 2011.04.15
  • Accepted : 2011.04.29
  • Published : 2011.06.30
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Abstract

We investigated the systemic effects of leaf folder (Cnaphalocrocis medinalis) resistant rice (transgenic rice, Nakdongbyeb) in Sprague-Dawley rats for 13 weeks. Leaf folder resistant rice was added to the diet at percentage levels of 0, 5 and 20 percentage/feeder and was administered for 13 weeks. The results did not show any changes in food and water intake. There were also no biologically significant changes in both body and organ weights, hematological and blood biochemical parameters, autopsy and histopathology between the treatment and control groups. Based on these results, no observed adverse effect level (NOAEL) of transgenic rice was considered to be more than 10,000 mg/kg b.w. under the conditions of the present study.

본 연구는 혹명나방 저항성 유전자 변형 낙동벼(GMO)의 식품으로서의 안전성을 평가하고자 13주 경구 반복투여 독성시험을 수행하였다. SD 랫드를 0, 5, 20%의 유전자 변형 낙동벼와 20% 낙동벼(Non-GMO)를 투여군으로 분리하여 13주간 투여한 후 체중, 사료섭취량, 요, 혈액 및 혈액생화학, 부검 및 조직병리학적 검사를 수행하였다. 시험종료시까지 모든 동물은 생존하였으며, GMO 벼의 투여와 관련된 독성은 관찰되지 않았다. 따라서 혹명나방 저항성 유전자 변형 낙동벼의 무독성량은 10,000 mg/kg/day 이상일 것으로 판단되며, 13주 경구 반복투여 독성은 없는 것으로 평가되었다.

Keywords

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