한국한의학연구원논문집 (Korean Journal of Oriental Medicine)

한국한의학연구원 (Korean Institute of Oriental Medicine)
권호 표지

흰쥐의 급성 대장염에 대한 주파수에 따른 전침 효과 연구

Frequency Dependent Electroacupuncture Modulates the Visceromotor Responses to Colonic Distension in TNBS-Induced Colonic Inflammatory Rats

  • 최윤영 (원광대학교 한의과대학 경혈학교실) ;
  • 양승범 (원광대학교 한의과대학 경혈학교실) ;
  • 안성훈 (원광대학교 한의과대학 경혈학교실) ;
  • 손인철 (원광대학교 한의과대학 경혈학교실) ;
  • 김재효 (원광대학교 한의과대학 경혈학교실)
  • Choi, Yun-Young (Dept. of Meridian & Acupoint, College of Korean Medicine, Wonkwang University) ;
  • Yang, Seung-Bum (Dept. of Meridian & Acupoint, College of Korean Medicine, Wonkwang University) ;
  • Ahn, Sung-Hun (Dept. of Meridian & Acupoint, College of Korean Medicine, Wonkwang University) ;
  • Sohn, In-Chu (Dept. of Meridian & Acupoint, College of Korean Medicine, Wonkwang University) ;
  • Kim, Jae-Hyo (Dept. of Meridian & Acupoint, College of Korean Medicine, Wonkwang University)
  • 투고 : 2011.08.25
  • 심사 : 2011.12.05
  • 발행 : 2011.12.31
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초록

Objectives : The transient inflammation has been demonstrated to alter visceral motor response (VMR) and acute mucosal inflammation may precede the manifestation of visceral hyperalgesia in animal models. The purpose of our study is to compare effects of the different frequencies applied electroacupuncture (EA) on acupoints in acute colitis induced by trinitrobenzenesulphonic acid (TNBS). Methods : In Male Sprague-Dawley rats, weighing 250~400g, a single colorectal administration of TNBS (5mg/kg) was made and electrode for electromyography (EMG) recording were stitched into the external oblique musculature. EA of either ST25 or ST36 were applied and stimulation parameter was modulated as follows: 2, 10, or 100 Hz with intensity of 2 mA and 1 ms pulse duration for 30 min. The balloon was inserted intra-anally and VMR to colorectal distension (CRD) was quantified with an EMG recording system. Results : The VMR increased significantly 3 days after TNBS intra-rectal colonic injection in rats. Both 2 Hz and 10 Hz EA on ST36 suppressed VMR to CRD in the acute colitis model but not 100 Hz. Only 10 Hz EA on ST25 suppressed VMR to CRD in the acute colitis. Conclusions : These data show that 10 Hz EA potently inhibits hypersensitivity of colorectum after TNBS induced colitis.

키워드

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