한국동물위생학회지 (Korean Journal of Veterinary Service)

  • 제34권2호
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  • Pages.103-109
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  • 2011
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  • 3022-7372(pISSN)
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  • 2287-7630(eISSN)
한국동물위생학회 (The Korean Society of Veterinary Service)
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구제역 Asia1 백신의 방어 유전형 분석

Analysis of protective genotype of foot-and-mouth disease (FMD) Asia1 vaccine

  • 이여주 (국립수의과학검역원 해외전염병과) ;
  • 초가기 (국립수의과학검역원 해외전염병과) ;
  • 이서용 (국립수의과학검역원 해외전염병과) ;
  • 김수미 (국립수의과학검역원 해외전염병과) ;
  • 이광녕 (국립수의과학검역원 해외전염병과) ;
  • 고영준 (국립수의과학검역원 해외전염병과) ;
  • 이향심 (국립수의과학검역원 해외전염병과) ;
  • 조인수 (국립수의과학검역원 해외전염병과) ;
  • 남석현 (아주대학교 생명과학과) ;
  • 박종현 (국립수의과학검역원 해외전염병과)
  • Lee, Yeo-Joo (Foreign Animal Disease Division, National Veterinary Research and Quarantine Service) ;
  • Chu, Jia-Qi (Foreign Animal Disease Division, National Veterinary Research and Quarantine Service) ;
  • Lee, Seo-Yong (Foreign Animal Disease Division, National Veterinary Research and Quarantine Service) ;
  • Kim, Su-Mi (Foreign Animal Disease Division, National Veterinary Research and Quarantine Service) ;
  • Lee, Kwang-Nyeong (Foreign Animal Disease Division, National Veterinary Research and Quarantine Service) ;
  • Ko, Young-Joon (Foreign Animal Disease Division, National Veterinary Research and Quarantine Service) ;
  • Lee, Hyang-Sim (Foreign Animal Disease Division, National Veterinary Research and Quarantine Service) ;
  • Cho, In-Soo (Foreign Animal Disease Division, National Veterinary Research and Quarantine Service) ;
  • Nam, Seok-Hyun (Department of Biological Science, Ajou University) ;
  • Park, Jong-Hyeon (Foreign Animal Disease Division, National Veterinary Research and Quarantine Service)
  • 투고 : 2011.03.31
  • 심사 : 2011.04.11
  • 발행 : 2011.06.30
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초록

Asia1/Shamir that has been recommended by World Reference Laboratory for foot-and-mouth disease (FMD) is used as a vaccine strain, and is being prepared in many countries including Korea. Although it is assumed that vaccine strain Asia1/Shamir has a wide antigenicity, sufficient molecular biological analysis has not been accomplished yet. Complete genome sequence analysis showed that the region with the most severe variations was 1D region of structural protein-coding sequence; particularly amino acid 141~157 residues in 1D region RGD sites for binding to susceptible cells. In addition, five amino acids in 1D region were identified as characteristic sites that are different from other known Asia1 viruses. Asia1/Shamir strain was shown to be genetically similar to group VI that had occurred in the Middle East, but showed low level of genetic similarity to the group V viruses that had occurred in the Southeast Asia and China. It is considered that, if these viruses, group I and II including group V are introduced into Korea, care would be paid in case of inoculating the vaccine strain Shamir available in Korea.

키워드

참고문헌

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