Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Testicular adrenal rest tumors in a patient with untreated congenital adrenal hyperplasia

  • Jin, Hye-Young (Division of Pediatric Endocrinology and Metabolism, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine) ;
  • Choi, Jin-Ho (Division of Pediatric Endocrinology and Metabolism, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine) ;
  • Kim, Gu-Hwan (Department of Pediatrics, Medical Genetics Clinic and Laboratory, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine) ;
  • Lee, Chung-Sik (Department of Pathology, Chungnam National University Hospital, Chungnam National University College of Medicine) ;
  • Yoo, Han-Wook (Division of Pediatric Endocrinology and Metabolism, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine)
  • Received : 2010.09.20
  • Accepted : 2010.10.29
  • Published : 2011.03.15
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Abstract

Testicular adrenal rest tumors (TARTs) are considered to be formed from aberrant adrenal tissue that has become hyperplastic because of elevated adrenocorticotropic hormone (ACTH) in male patients with congenital adrenal hyperplasia (CAH). A 6-year-old boy presented with testicular enlargement and pubic hair. He was diagnosed with CAH complicated by precocious puberty. However, he was not followed-up. At the age of 17, he visited the outpatient clinic because of testicular enlargement and short stature. His right and left testicles were $10{\times}6$ cm and $7.5{\times}4.5$ cm, respectively. His height was 155.1 cm (standard deviation score (SDS), -2.90). The diagnosis of CAH due to 21 hydroxylase deficiency was confirmed by mutation analysis of CYP21A2. Histological examination of the testes showed large, polygonal, eosinophilic cells with round nuclei and prominent nucleoli, which were suggestive of TARTs. He was treated with dexamethasone for 3 weeks and tumors regressed. Subsequently, dexamethasone was replaced by prednisolone and $9{\alpha}$-fludrocortisone; thereafter, the reduced testis size has been maintained.

Keywords

References

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