Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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The experimental study of oral care for early radiation therapy in the head and neck cancer patients

두경부 악성종양 환자에서 조기 방사선치료를 위한 구강관리법에 대한 실험적 연구

  • Moon, Won-Kyu (Department of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University) ;
  • Cha, In-Ho (Department of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University) ;
  • Kim, Hyung-Jun (Department of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University) ;
  • Jung, Young-Soo (Department of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University) ;
  • Lee, Chun-Ui (Department of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University) ;
  • Lee, Jong-Young (Department of Radiation Oncology, Wonju College of Medicine, Yonsei University) ;
  • Ryu, Mi-Heon (Department of Oral Pathology, School of Dentistry, Yangsan Campus of Pusan National University) ;
  • Yoo, Jae-Ha (Department of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University)
  • 문원규 (연세대학교 치과대학 구강악안면외과학교실) ;
  • 차인호 (연세대학교 치과대학 구강악안면외과학교실) ;
  • 김형준 (연세대학교 치과대학 구강악안면외과학교실) ;
  • 정영수 (연세대학교 치과대학 구강악안면외과학교실) ;
  • 이천의 (연세대학교 치과대학 구강악안면외과학교실) ;
  • 이종영 (연세대학교 원주의과대학 방사선종양학교실) ;
  • 유미현 (부산대학교 치의학전문대학원 전문대학원 구강병리학교실) ;
  • 유재하 (연세대학교 치과대학 구강악안면외과학교실)
  • Received : 2011.01.09
  • Accepted : 2011.06.07
  • Published : 2011.06.30
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Abstract

Background: Teeth requiring extraction before radiotherapy in head & neck cancer patients should be removed as long as possible before the initiation of radiation therapy. Conventionally, a minimum 2-week waiting primary healing period is recommended. Although the above 2-week period is ideal, it was not uncommon for the radiotherapist and cancer patient to feel an urgent need to process with radiotherapy despite the need for dental care. Therefore, alternative approaches for early radiotherapy, including conservative endodontic treatment and a 1-week waiting primary healing period after dental extraction at the time of radiotherapy, were considered and applied based on the experimental study Materials and Methods: Eighteen dogs were processed for histopathologic wound healing. The effect of the primary endodontic treatment and extraction before early radiotherapy was examined. Results: No specific complication, such as, post-extraction wound infection, radiation osteitis and osteoradionecrosis, were encountered despite the early radiotherapy. Conclusion: Based on the experimental study, a minimum 1-week waiting primary healing period for oral care before radiotherapy is suitable for the early radiotherapy in head and neck cancer patients.

Keywords

References

  1. Goo KS. Experimental study for the initiation of irradiation effects on the tooth extraction wounds in rats. J Korean Assoc Oral & Maxillofac Surg 1979;5:45-60.
  2. Kim YG. Dental care of oral cancer patients. Journal of Korean Dental Association 1986;24:587-95.
  3. Laskin DM. Oral and maxillofacial surgery, Vol II. 1st ed. Saint Louis: CV Mosby; 1985:42-7.
  4. Lederman M. Complications of radiation therapy for cancer of the head and neck. In：Conley JJ, ed. Complications of head and neck surgery. 1st ed. Philadelphia: W.B. Saunders; 1979:329-52.
  5. Sonis ST, Fazio RC and Fang L. Principles and practice of oral medicine. 2nd ed. Philadelphia: WB Saunders; 1995:406-11.
  6. Peterson LJ, Ellis III E, Hupp JR, Tucker MR. Contemporary oral and maxillofacial surgery, 3rd ed. Saint Louis: CV Mosby; 1998:425-36.
  7. Cohen S, Burns RC. Pathways of the pulp. 8th ed. Seoul: Shin Hung International Publication; 2003:65-6.
  8. Grossman LI. Endodontic practice. 8th ed. Philadelphia: Lea & Febiger; 1974:151-68.
  9. Lim SS. Clinical endodontics. 1st ed. Seoul: Medical and Dental Publishing; 1994:1-15.
  10. Kim GW, Kim KW, Kim SG, Kim YK, Kim YK, Kim JR et al. Oral and maxillofacial infections. 1st ed. Seoul: JeeSung Publishing; 2007:265-88.
  11. Lee EW. Experimental study for irradiation effects on the jaw and tooth extraction wounds in rats. Yonsei J Dental Sci. 1981;1: 214-24.
  12. Little JW, Falace DA. Dental management of the medically compromised patients. 5th ed. Saint Louis: CV Mosby; 1997:460-82.
  13. Kim MG, Kim YK, Kim YG, Rew DM, Lee JH, Cha IH et al. Oral cancer. 1st ed. Seoul: Jee Sung Publishing; 2002:498-805.
  14. The Korean Association of Oral and Maxillofacial Surgeons. Textbook of oral and maxillofacial surgery. 2nd ed. Seoul: Medical & Dental Publishing; 2005:460-73.
  15. Kim JB, Nam KY, Chung WG, Noh HJ, Jang SO, Yoo JH, et al. A clinical study on the care of oral complications in the admission patients with major malignant tumors. J Korean Assoc Maxillofac Plastic Reconstruc Surg 2004;26:53-60.
  16. Rew SY, Park MS. Retrospective study of the oral cancer patients: a statistical analysis of 89 cases. J Korean Assoc Oral Maxillofac Surg 1996;22:643-58.
  17. Suh GH, Kim OH. Clinical studies of malignant tumors in oral and maxillofacial region. J Korean Assoc Maxillofac Plast Reconstruc Surg 1990;12:82-95.
  18. Baek JY, Choi SW, Lee EW, Choi EC, Cha IH. A clinical study of malignant tumors of the maxilla. J Korean Assoc Oral Maxillofac Surg 2000;26:391-5.
  19. Kim YG, Yoo HS, Kwak JG, Kim GY. A clinical study of the osteoradionecrosis of the jaw. J Korean Assoc Oral Maxillofac Surg 1993;19:177-84.
  20. Cho BH, Min SK, Oh SH, Lee DK, Kim YG. Retrospective study on the influencing factors of survival rate after treatment of oral cancer. J Korean Assoc Maxillofac Plast Reconstruc Surg 2002; 24:211-7.
  21. Kim YI. Radiation therapy. 1st ed. Seoul: Shin Kwang Publication; 1984:10-36.
  22. Hur J. Radiation Biology. Seoul: Ko Moon Sa Publication; 1987: 51-158.
  23. Marx RE, Johnson RP. Studies in the radiobiology of osteoradionecrosis and their clinical significance. Oral Surg Oral Med Oral Pathol. 1987;64:379-90. https://doi.org/10.1016/0030-4220(87)90136-8
  24. Peterson DE. Prevention of oral complications in cancer patients. Prev Med 1994;23:763-5. https://doi.org/10.1006/pmed.1994.1131
  25. Markitziu A, Horn Y, Ulmansky M. Effect of single versus fractionated doses of x-radiation on developing molars in rats. J Dent Res 1974;53:637-40. https://doi.org/10.1177/00220345740530032001
  26. Sweeney WT, Richard PE, Seymour HL. Histologic effect of fractionated doses of selectively applied 60Co irradiation on the teeth of Albino rats. J Dent Res 1977;56:1403-7. https://doi.org/10.1177/00220345770560112101
  27. Daly TE. Dentistry for the irradiated head and neck cancer patient. Cancer Bull 1979;29:74-80.
  28. Mossman KL, Henkin RI. Radiation-induced changes in taste acuity in cancer patients. Int J Radiat Oncol Biol Phys 1978;4:663-70. https://doi.org/10.1016/0360-3016(78)90190-6
  29. Nikoskelainen J. Oral infections related to radiation and immunosuppressive therapy. J Clin Periodontol 1990;17:504-7. https://doi.org/10.1111/j.1365-2710.1992.tb01224.x
  30. Peterson DE, D'Ambrosio JA. Nonsurgical management of head and neck cancer patients. Dent Clin Nor Am 1994;38:425-45.
  31. Shklar G. Oral cancer: the diagnosis, therapy, management, and rehabilitation of the oral cancer patient. Philadelphia: WB Saunders; 1984:138-43.
  32. Carl W, Schaaf NG, Sako K. Oral surgery and the patient who has radiation therapy for head and neck cancer. Oral Surg Oral Med Oral Pathol 1973;36:651-6. https://doi.org/10.1016/0030-4220(73)90134-5
  33. Regezi JA, Courtney RM, Kerr DA. Dental management of patients irradiated for oral cancer. Cancer 1976;38:994-1000. https://doi.org/10.1002/1097-0142(197608)38:2<994::AID-CNCR2820380251>3.0.CO;2-B
  34. Marx RE. A new concept in the treatment of osteoradionecrosis. J Oral Maxillofac Surg 1983;41:351-7. https://doi.org/10.1016/S0278-2391(83)80005-6
  35. Topazian RG, Goldberg MH. Management of infections of the oral and maxillofacial regions. 1st ed. Philadelphia: WB Saunders; 1981:258-65.
  36. Kim KW, Kim GS. Guideline of oral cancer care. 1st ed. Seoul: Oral Cancer Institute of Korean Assoc Oral & Maxillofac Surg; 2008:67-72.
  37. Kimura Y, Yonaga K, Murakosi M, Yokoyama K, Watanabe H, Matsumoto K. Effects on periradicular periodontal tissues of root canal irradiation with Er: YAG Laser in rats. Photomed and Laser Surg 2004;22:335-41. https://doi.org/10.1089/pho.2004.22.335
  38. Choi SI, Cho ES, Lee SW. Expression of COX-2 & VEGF in dental periapical lesions. Korean J Oral Maxillofac Pathol 2006;30:53-60.
  39. Chavez JA, Adkinson CD. Adjunctive hyperbaric oxygen in irradiated patients requiring dental extractions: outcomes and complications. J Oral Maxillofac Surg 2001;59:518-24. https://doi.org/10.1053/joms.2001.22680
  40. Shafer WG, Hine MK, Levg BM. A textbook of oral pathology. 4th ed. Philadelphia: WB Saunders; 1983:594-608.